
04/02/2025
The importance of medical laboratories in addressing Antimicrobial Resistance (AMR) and Healthcare-associated Infections (HAIs).
Antimicrobial Resistance (AMR) and Healthcare-Associated Infections (HAIs) are critical public health challenges, particularly in regions like Zambia. AMR occurs when microorganisms evolve to resist the effects of medications, rendering standard treatments ineffective and leading to persistent infections. HAIs, also known as nosocomial infections, are infections that develop 48 hours or more after hospitalization or within 30 days after receiving care. Notably, pathogens responsible for HAIs are among the leading causes of AMR-related deaths globally.
Global and Zambian Context
In 2019, bacterial AMR was associated with approximately 4.95 million deaths worldwide. In Zambia, a 2022 study estimated around 242,000 HAIs annually, resulting in approximately 25,100 excess deaths each year. The case fatality rate for HAIs in Zambia was estimated at 6.9%, with AMR contributing to higher mortality rates.
The Critical Role of Medical Laboratories
Medical laboratories are pivotal in combating AMR and HAIs through:
1. Screening: Laboratories can identify patients harbouring resistant HAI pathogens before admission or surgery, enabling the implementation of stringent infection prevention and control (IPC) measures.
2. Detection: By identifying pathogens and determining their susceptibility or resistance to antibiotics, laboratories guide effective patient management within healthcare facilities.
3. Surveillance: Conducting surveillance of HAIs allows laboratories to determine the prevalence of resistant infections, facilitate IPC measures, detect outbreaks, and assess the impact of interventions.
Advancements in Diagnostic Technologies
Recent developments, such as rapid sepsis tests, have the potential to significantly reduce the time required to identify pathogens and determine effective treatments, thereby improving patient outcomes and reducing reliance on broad-spectrum antibiotics.
Conclusion
Strengthening medical laboratory capacities is essential to mitigate the public health threats posed by AMR and HAIs. By enhancing screening, detection, and surveillance capabilities, laboratories can play a transformative role in improving patient outcomes and safeguarding public health.