05/09/2026
๐ด Study: Aute Heart Failure in Africa (Lancet, 2026)
Aetiology, Management, and Outcomes of Aute Heart Failure across 17 African Countries: A Prospective, Multicentre, Observational Cohort Study
โข 50 hospitals across 17 African countries
โข 1,578 pts with acute HF
โข Enrolment period: July 2024 โ July 2025
โข Follow-up: 180 days
โข 17 Participating Countries: Angola, Botswana, Cameroon, Democratic Republic of Congo, , Ghana, Mauritania, Mozambique, Namibia, Nigeria, Sรฃo Tomรฉ and Prรญncipe, South Africa, Sudan, Tanzania, Tunisia, Uganda, Zambia.
Demographic Data
โข Median age: 56 years (IQR 40โ69)
โข Female: 50.5%
โข African descent: 97.8%
Cardiovascular Risk Factors & Comorbidities
โข Hypertension: 62.7%
โข Diabetes: 20.3%
โข Dyslipidaemia: 15.8%
โข HIV-positive: 3.4%
Leading Aetiologies of AHF
1. Hypertensive heart disease: 36.5%
2. Cardiomyopathy: 23.4%
3. Ischaemic heart disease: 23.3%
4. Other causes: 6.8%
Clinical Presentation โ Median (IQR)
โข BMI: 23.7 kg/mยฒ (21.2โ27.4)
โข Systolic BP: 124 mmHg (107โ142)
โข Diastolic BP: 80 mmHg (70โ93)
โข Heart rate: 96 bpm (82โ108)
โข NYHA Class at Admission:
โ Class I: 4.2%
โ Class II: 8.5%
โ Class III: 29.6%
โ Class IV: 57.7%
โข De novo HF: 64.2%
Lab investigations โ Median (IQR), pg/mL
โข NT-proBNP: 1,879 (140โ6,305)
โข NT-proBNP (measured or BNP-converted): 1,993 (140โ7,164)
ECG: Atrial fibrillation/flutter - 20.9%
Echocardiography โ Median (IQR)
โข LVEDD: 58 mm (49โ65)
โข LVEF: 38% (28โ55)
Rx at Discharge:
Among pts with available data
โข ฮฒ-blockers: 76.9%
โข RAAS inhibitors: 73.9%
โข MRAs: 71.9%
โข SGLT2 inhibitors: 54.7%
Fewer than 50% of pts reached target doses across all major HF medication classes.
Key Outcomes:
โข In-hospital mortality: 8.7%
โข 30-day mortality: 11.1%
โข 180-day mortality: 20.6%
โข Lost to follow-up before 180 days: 33.7%
Key Takeaways:
1. Hypertensive heart disease is now the leading cause of acute HF in Africa.
2. Pts are relatively young but face high short- and long-term mortality.
3. Use of GDMT is high, but target doses are achieved in fewer than half of pts.
4. Large loss to follow-up underscores the need for strong post-discharge follow-up systems.
5. Greater focus is needed on prevention, access to cardiac care, GDMT optimization, & continuity of care.
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)01657-0/abstract?rss=yes