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Nucleosides in central carbon metabolism

Nucleosides and nucleic acids are abundant in our diet, but their nutritional value has been poorly investigated. Nucleosides maintain the viability of cells and organs when glucose is limited.

Specific nucleoside phosphorylases, including uridine phosphorylase 1/2 (UPP1/2), thymidine phosphorylase (TYMP), and purine nucleoside phosphorylase (PNP), catalyze nucleoside cleavage and release of the ribose moiety, which can enter the glycolytic pathway, thus fueling central carbon metabolism. UPP1/2 integrate genetic and environmental signals to regulate uridine catabolism.

Energy production from nucleosides has major implications for metabolism, immunity, and cancer.

https://www.cell.com/trends/endocrinology-metabolism/fulltext/S1043-2760(24)00027-4
http://sciencemission.com/site/index.php?page=news&type=view&id=publications%2Fnucleosides-are&filter=22