10/02/2026
More frequent testosterone administrations generally mean smaller peaks, smaller troughs, and more stable levels over time.
Every two weeks may work for some patients, but I generally recommend at least once weekly, and often twice weekly. Larger, less frequent doses can produce much greater fluctuations and may contribute to side effects in some patients.
For most patients using physiologic replacement doses, twice weekly is plenty. There’s usually no need to overcomplicate it.