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Oxford Healthspan Age well with Primeadine.

10/13/2026

Autophagy is a cellular recycling process that becomes less efficient with age. 🔬

As we get older, maintaining this process becomes increasingly important, which is why researchers are so interested in signals that can help activate it.

Exercise, fasting, and certain food-derived compounds have all been studied for their effects on autophagy. (Did you know that to get the full benefits of fasting, spermidine needs to be present?)

Spermidine is one such compound. This naturally occurring polyamine has been studied for its ability to stimulate autophagy, making it an especially compelling focus in healthy aging research. 🌿

Eating with the seasons is a simple way to keep variety in your diet and enjoy produce when it’s naturally at its best. ...
10/08/2026

Eating with the seasons is a simple way to keep variety in your diet and enjoy produce when it’s naturally at its best. 🍎🥦

Seasonal fruit and vegetables are often harvested closer to peak ripeness, which can mean better flavor and a shorter journey from farm to plate.

We pulled together a few October favorites and highlighted some of the longevity-related compounds found in each one. 🌿

A seasonal grocery list, with a little cellular biology built in.

The o***y is one of the first organs to show age-related functional decline. Research suggests changes in ovarian functi...
10/07/2026

The o***y is one of the first organs to show age-related functional decline. Research suggests changes in ovarian function can become evident as early as the 30s, making reproductive aging a compelling window into cellular decline over time 🧬

A 2023 Nature Aging study explored where spermidine fits into that picture. In aged mice, researchers observed lower ovarian spermidine levels. Supplementation was associated with improvements in several reproductive outcomes, alongside enhanced mitophagy and mitochondrial function. 🔬

Mitophagy is the process cells use to identify and recycle damaged mitochondria. Given that mitochondrial quality is essential for oocyte function, this pathway represents a promising focus area in reproductive health.

Spermidine-induced mitophagy has also been documented in cultured human fibroblasts via the PINK1/Parkin pathway, adding additional support to the mechanistic model. 🧫

These initial findings are preclinical. Future human research will help clarify how these mechanisms translate to clinical practice.

Swipe through to explore the study breakdown and the biology behind it. 👉

10/06/2026

Wheat germ-derived spermidine that hasn’t been defatted contains fats that are prone to oxidation. 🌾

Wheat germ is naturally rich in spermidine, but it also contains polyunsaturated fats, including omega-6 fatty acids, which are especially vulnerable to oxidation once exposed to air.

That’s why we use defatted wheat germ extract in Primeadine® Original. Removing the oil fraction helps reduce the presence of these oxidation-prone fats while retaining the polyamine-rich extract we’re looking for. 🔬

Dietary fats can influence the fatty acid composition of our cell membranes, causing dysfunction, which is one reason we pay such close attention to the quality of our ingredients.

In this conversation with Dr. Stephanie Estima, Leslie explains why this extra step matters.

When you invest in your cellular health, you want the ingredients you receive to reflect that same level of care. 💚

Primeadine GF is built around three carefully selected Okinawan ingredients. 🌿We tested more than 100 different chlorell...
10/01/2026

Primeadine GF is built around three carefully selected Okinawan ingredients. 🌿

We tested more than 100 different chlorella substrains in Okinawa to find one naturally rich in spermidine. 🔬

We paired it with Okinawan lime peel, chosen for its naturally high nobiletin content, and Okinawan autumn turmeric, valued for its curcuminoids and long history of use in the region. 🍋✨

One of our favorite things about our community is hearing how unique everyone’s Primeadine® journey is.Hair comes up sur...
09/30/2026

One of our favorite things about our community is hearing how unique everyone’s Primeadine® journey is.

Hair comes up surprisingly often in our messages. Sometimes it’s a subtle shift you notice in the mirror, and other times it’s a friend or hairdresser asking what you’ve been doing differently ✂️

Have you noticed anything since adding Primeadine to your routine? Tell us in the comments! ✨

09/29/2026

Primeadine®️ GF has officially landed at the zen like oasis, Laurel Supply in West Hollywood! 💚

If you’ve been looking for a local place to pick up your Primeadine, you can now find Primeadine GF on the shelves of one of our new fave wellness spots. 🌿

A little shopping, a little zen, and your Primeadine restock all in one stop ☯️ ✨

If you’re in LA, stop by and look out for us on the shelf.

And if you spot Primeadine someplace else out in the wild, tag us. We love seeing where you find us! 👀

Add a little cellular renewal to your daily ritual 🍵💚Primeadine® GF mixes seamlessly into matcha, making spermidine an e...
09/24/2026

Add a little cellular renewal to your daily ritual 🍵💚

Primeadine® GF mixes seamlessly into matcha, making spermidine an easy addition to your daily routine.
Ceremonial-grade matcha, your milk of choice, a touch of maple syrup, and Primeadine GF. Easy, creamy, and perfect for slow mornings. ✨

Save this recipe for the next time you’re making an iced (or hot) matcha. 🍵

Add a little cellular renewal to your daily ritual 🍵💚 Primeadine® GF mixes seamlessly into matcha, making spermidine an ...
09/24/2026

Add a little cellular renewal to your daily ritual 🍵💚

Primeadine® GF mixes seamlessly into matcha, making spermidine an easy addition to your daily routine.
Ceremonial-grade matcha, your milk of choice, a touch of maple syrup, and Primeadine GF. Easy, creamy, and perfect for slow mornings. ✨

Save this recipe for the next time you’re making an iced (or hot) matcha. 🍵

Why we deliberately strip the oil out of our wheat germ. 🌾Wheat germ is naturally rich in spermidine, but it’s also high...
09/23/2026

Why we deliberately strip the oil out of our wheat germ. 🌾

Wheat germ is naturally rich in spermidine, but it’s also high in delicate polyunsaturated fats. Once milled and exposed to oxygen, these fragile oils can degrade rapidly.

That’s why we use defatted wheat germ extract in Primeadine® Original. We isolate and remove the unstable oil fraction while fully preserving the naturally occurring polyamines and cofactors.

How an ingredient is handled, protected, and formulated matters just as much as ingredient quality and sourcing.

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