Journal of Experimental Medicine

Journal of Experimental Medicine The Journal of Experimental Medicine publishes immunology, cancer, stem cells, microbial pathogenesis, vascular biology, and neurobiology research.

Since its inception in 1896, the goal of The Journal of Experimental Medicine (JEM) has been to publish outstanding and enduring studies in medical biology. At a time when many leading publishing groups are establishing topic-specific journals, we believe it is critical to complement that approach by offering a distinguished venue for publication of studies that integrate disciplines within the fi

eld of pathogenesis. A distinctive editorial system supports this goal with an emphasis on exceptional service to our authors. Two groups of editors work hand-in hand: professional editors with strong scientific backgrounds, and full-time practicing scientists. At least one editor from each group evaluates the merits of each paper prior to external review. The editors convene weekly to discuss all papers with external referee comments, and reach rapid decisions without excessive requests for revision. Within the field of medical biology we focus both on human studies and diverse in vivo experimental models of human disease that address such topics as genetics, inflammation, immunity, infectious disease, cancer, vascular biology, metabolic disorders, neuroscience, and stem cell biology. We welcome reports ranging from atomic-level analyses to clinical interventions that illustrate new mechanisms.

Márcia Mesquita Peixoto, Francisca Soares-da-Silva, Valentin Bonnet, Yanping Zhou, Charles N. Baroud, Perpétua Pinto-do-...
01/07/2025

Márcia Mesquita Peixoto, Francisca Soares-da-Silva, Valentin Bonnet, Yanping Zhou, Charles N. Baroud, Perpétua Pinto-do-Ó, Ana Cumano (Institut Pasteur) et al. show that hepatoblasts in the fetal liver are the primary source of factors that sustain blood cell production. Different hematopoietic progenitors exhibit distinct preferences for neighboring stromal cells and show developmental changes in spatial distribution. https://hubs.la/Q031ssxn0

Our January issue is here! https://hubs.la/Q0314wVj0On the cover: Ray et al. (https://hubs.la/Q0314NPK0) reported that t...
01/06/2025

Our January issue is here! https://hubs.la/Q0314wVj0
On the cover: Ray et al. (https://hubs.la/Q0314NPK0) reported that targeting CD206+ macrophages disrupts antitumor immunity. The image represents CD206+ macrophage population by Venus expression (in yellow) using two-photon microscopy of B78chOVA tumor slices with transferred OT-I T cells marked by CD2dsRed (in red).

Insights: Jacob Myers, Shanelle Reilly, and Laurent Brossay (Brown University) discuss new study by Sparano et al. (http...
01/03/2025

Insights: Jacob Myers, Shanelle Reilly, and Laurent Brossay (Brown University) discuss new study by Sparano et al. (https://hubs.la/Q0314Xbc0) which shows that tissue-resident NK cells produce TGF-β1 themselves to establish and maintain residency in glandular tissues. https://hubs.la/Q0314PsB0

Douglas Prado, William Hawse and colleagues (University of Pittsburgh) discovered that PIKFYVE and its product PtdIns(3,...
01/02/2025

Douglas Prado, William Hawse and colleagues (University of Pittsburgh) discovered that PIKFYVE and its product PtdIns(3,5)P2 are essential regulators of Th17 differentiation. Their findings identify molecular mechanisms by which PIKFYVE promotes Th17 differentiation and suggest that PIKFYVE is a potential therapeutic target in Th17-driven autoimmune diseases. https://hubs.la/Q030_Wb90

Rapid capture of potentially harmful bacteria in blood by liver macrophages is vital for blood sterility and health. Xia...
12/24/2024

Rapid capture of potentially harmful bacteria in blood by liver macrophages is vital for blood sterility and health. Xianbin Tian, Yanni Liu, Jing-Ren Zhang and colleagues (Tsinghua University) report how naturally occurring antibodies in the plasma enable macrophages to capture and kill blood-borne bacteria in the liver. https://hubs.la/Q030zTMP0

Insights: Mitchell Kronenberg and Gabriel Ascui (La Jolla Institute for Immunology) discuss new work from Hosono et al. ...
12/23/2024

Insights: Mitchell Kronenberg and Gabriel Ascui (La Jolla Institute for Immunology) discuss new work from Hosono et al. (https://hubs.la/Q030wCGb0) that characterizes a putative self-glycolipid that engages the iNKT cell TCR when bound to CD1d. https://hubs.la/Q030wHPc0

α-Galactosylceramide (α-GalCer), a marine sponge-derived canonical antigen for invariant natural killer T (iNKT) cells, ...
12/20/2024

α-Galactosylceramide (α-GalCer), a marine sponge-derived canonical antigen for invariant natural killer T (iNKT) cells, has not been detected in mammals. In this study, Yuki Hosono, Noriyuki Tomiyasu, Hayato Kasai, Yoshihiro Izumi (Kyushu University), Sho Yamasaki (Osaka University) and colleagues report the molecular detection of α-GalCer in mammals using supercritical fluid chromatography tandem mass spectrometry.

Vidyanath Chaudhary, Franck Barrat and colleagues (Hospital for Special Surgery) describe the mechanism by which increas...
12/13/2024

Vidyanath Chaudhary, Franck Barrat and colleagues (Hospital for Special Surgery) describe the mechanism by which increased stiffness in the skin regulates the activation of pDCs, and how this process is dysregulated in patients with systemic sclerosis due to the presence of inflammatory mediators such as nucleic acid-binding chemokines. https://hubs.la/Q02_BVw90

See related study from the Barrat lab: https://hubs.la/Q02_BVFW0

Yong Du, Bérénice Faz-Lopez, Jean-Charles Guéry (Université de Toulouse), Franck Barrat (Hospital for Special Surgery) a...
12/13/2024

Yong Du, Bérénice Faz-Lopez, Jean-Charles Guéry (Université de Toulouse), Franck Barrat (Hospital for Special Surgery) and colleagues describe that TLR7 and TLR8 escape X-chromosome inactivation in plasmacytoid DCs of patients with systemic sclerosis, which is associated with decreased expression of components of the XCI machinery and increased presence of pDC subclusters with high IFN-I signature. https://hubs.la/Q02_C37j0

See related study from Chaudhary et al.: https://hubs.la/Q02_C0-J0

Joan Shang, David Faleck, Jeremiah Faith and colleagues (Icahn School of Medicine at Mount Sinai) report that pretreatme...
12/12/2024

Joan Shang, David Faleck, Jeremiah Faith and colleagues (Icahn School of Medicine at Mount Sinai) report that pretreatment gut microbiomes of immunotherapy-related colitis patients drive worse colitis in susceptible mice compared with non-colitis cancer immunotherapy microbiomes. Microbiome shifts in immunotherapy-related colitis initially mirror inflammatory bowel disease patients but subsequently resolve suggesting a reversible, colitogenic state. https://hubs.la/Q02_qNJ10

Using a mouse model of ischemic stroke, Yun Hwa Choi, Zsuzsanna Fabry and colleagues (University of Wisconsin-Madison) s...
12/12/2024

Using a mouse model of ischemic stroke, Yun Hwa Choi, Zsuzsanna Fabry and colleagues (University of Wisconsin-Madison) show stroke-induced lymphangiogenesis at the cribriform plate (CP), suggesting increased drainage of the inflamed brain. Blocking CP lymphangiogenesis with a VEGFR-3 inhibitor improves stroke outcome, but administration of VEGF-C induces larger brain infarcts. https://hubs.la/Q02_qW_m0

Léa Bernaleau, Manuele Rebsamen and colleagues (Université de Lausanne) use a loss-of-function genetic screen to identif...
12/10/2024

Léa Bernaleau, Manuele Rebsamen and colleagues (Université de Lausanne) use a loss-of-function genetic screen to identify the ER-resident protein CCDC134 as an essential regulator of Toll-like receptor (TLR) responses. CCDC134 binds and stabilizes the TLR chaperone Gp96, controlling thereby the folding and trafficking of the plasma membrane and endolysosomal TLRs. https://hubs.la/Q02_5QWY0

STAG2 is a frequently mutated cohesin subunit across several cancers and one of the most important functional suppressor...
12/09/2024

STAG2 is a frequently mutated cohesin subunit across several cancers and one of the most important functional suppressors of lung adenocarcinoma. New findings from Emily Ashkin, Monte Winslow and colleagues (Stanford Medicine) underscore important roles of STAG2 in suppressing lung tumorigenesis and highlight a STAG2-PAXIP1/PAGR1 tumor-suppressive program that may transcend cancer type. https://hubs.la/Q02-YglJ0

New Insights: Erika Valeri and Anna Kajaste-Rudnitski (Università degli studi di Pavia) highlight two complementary work...
12/06/2024

New Insights: Erika Valeri and Anna Kajaste-Rudnitski (Università degli studi di Pavia) highlight two complementary works by Chan et al. (https://hubs.la/Q02-JX6c0), and Ru et al. (https://hubs.la/Q02-JTyv0), which identify defective RNA processing as the root cause of impaired antiviral immunity against SARS-CoV2 in the human brainstem. These studies provide molecular insight into virus-associated severe brainstem encephalitis through PKR inactivation. https://hubs.la/Q02-JX-v0

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Happy International #DayOfImmunology! In this special interview, JEM’s Deputy Editor Gaia Trincucci speaks with Dr. Arlene Sharpe (Harvard Medical School) & Dr. Kristen Pauken ({{facebook_mention(8760099910|MD Anders
Happy International #DayOfImmunology! In this special interview, JEM’s Deputy Editor Gaia Trincucci speaks with Dr. Arlene Sharpe (Harvard Medical School) & Dr. Kristen Pauken ({{facebook_mention(8760099910|MD Anders

Happy International #DayOfImmunology! In this special interview, JEM’s Deputy Editor Gaia Trincucci speaks with Dr. Arlene Sharpe (Harvard Medical School) & Dr. Kristen Pauken (MD Anderson Cancer Center) who share their stories as immunologists and insights into career paths as #WomeninSTEM. Full interview here ▶️ https://hubs.la/Q02vl5f30

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