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The USA Patient Network consists of patients, caregivers, and their friends and family members that are united by a common goal: to make sure that medical treatments are as safe, effective, and as affordable as possible. The USA Patient Network is a network of trained patient advocates ready and willing to provide patient perspectives and feedback on research design and strategy issues to federal agencies and researchers whose work determines which outcome measures provide adequate evidence of the safety and effectiveness of treatments. We focus on on the clinical research designs and criteria needed to prove the safety and effectiveness of medical products as a way of introducing patients to the scientific and statistical concepts that are especially important to patients. Because of the relatively small number of patient partners independently participating in FDA public forums, meetings, and other stakeholder events, the opportunities to do so will be a major focus of the proposed project. however, the Network and training will be very useful to patient partners who want to share their perspectives with other federal public health agencies as well as with university researchers.

10/20/2026

Atrazine, banned by 63 other countries, is linked to lymphomas, breast cancer, reduced fertility and multiple birth defects—but we don’t actually need it to grow food for people.

10/20/2026

Hormone therapy decisions are highly individual,and so are the potential risks and benefits.

A new clinical perspective examines evidence suggesting that estrogen-only therapy may lower breast cancer risk among women who have had a hysterectomy. These findings do not apply to every woman or every type of hormone therapy, and researchers say more data are needed on the forms of estrogen most commonly prescribed today.

Breast cancer is also only one part of the conversation. Personal and family history, cardiovascular and clotting risks, the type and delivery method of hormone therapy, and individual symptoms and goals all matter.

Read more: https://tinyurl.com/5n6u9cse

10/19/2026

On 15 October 2026, the UK's Medicines and Healthcare products Regulatory Agency (MHRA) announced new warnings for SSRI and SNRI antidepressants. These will include a new boxed warning in the patient information leaflet for suicidal thoughts and behaviours, a new patient card, a supporting safety le...

10/16/2026

Long COVID is characterized by persistent symptoms following SARS-CoV-2 infection and has been linked to abnormal thromboinflammatory processes in the blood.

Individuals with the condition show substantially higher numbers and larger sizes of circulating microclots, which are amyloid-like fibrin aggregates small enough to obstruct capillary flow yet resistant to normal breakdown.

These microclots coexist with elevated neutrophil extracellular traps, or NETs, which are web-like DNA and protein structures extruded by neutrophils to capture pathogens.

Recent investigations demonstrate a previously unreported structural association in which NETs become physically embedded within the microclots.

This embedding is present in healthy blood as well but is markedly more pronounced among Long COVID patients.

The sticky NET mesh appears to stabilize the fibrin structures, shielding them from fibrinolysis, the enzymatic process that normally dissolves clots.

As a result, microclots persist longer in the circulation, potentially impairing microvascular perfusion, reducing oxygen delivery to tissues, and contributing to chronic endothelial injury.

Markers of both microclots and NETs correlate strongly with each other and exhibit high diagnostic accuracy in distinguishing patients from controls.

These observations point to a dysregulated interaction between immune-derived NETs and fibrin amyloid particles that may help drive the microvascular complications and lingering symptoms of Long COVID.

Source: Thierry AR, et al. Circulating Microclots Are Structurally Associated With Neutrophil Extracellular Traps and Their Amounts Are Elevated in Long COVID Patients. Journal of Medical Virology. 2025;97(10):e70613. DOI: 10.1002/jmv.70613.

10/13/2026

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