Society of Toxicology (SOT)

Society of Toxicology (SOT) The Society of Toxicology (SOT) is a professional and scholarly organization of scientists from academic institutions, government, and industry representing the great variety of individuals who practice toxicology in the US and abroad.
The Society of Toxicology (SOT) is a professional and scholarly organization of scientists from academic institutions, government, and industry representing the great variety of individuals who practice toxicology in the US and abroad. The Society promotes the acquisition and utilization of knowledge in toxicology, aids in the protection of public health, facilitates disciplines, and has a strong commitment to education in toxicology and to the recruitment of students and new members into the profession.

The Society of Toxicology (SOT) is a preeminent scientific organization for professionals involved in toxicology. Founded in 1961, the Society is a global organization with more than 8,000 members from all over the world. The Society is a not-for-profit organization dedicated to the vision of creating a safer and healthier world by advancing the science of toxicology. Toward this vision, SOT strives to increase the scientific impact of the science of toxicology, promote the awareness of and recognition of scientific achievements within toxicology, build for the future of toxicology, and is dedicated to increasing the visibility of the organization and its members as scientific leaders. The Society’s members represent the broad spectrum of sciences that toxicology encompasses, ranging from the more mature disciplines of pharmacology, biology, chemistry, microbiology, molecular biology, pathology, pharmacy, and veterinary sciences to the emerging disciplines of genomics, proteomics, and bioinformatics. Members are drawn from academic institutions, industry, government agencies, nonprofit organizations, and private consulting firms and work together to help the organization advance science to enhance and protect human, animal, and environmental health.

Mission: The Society of Toxicology is the leading organization dedicated to creating a safer and healthier world by advancing the science of toxicology.

Highlights of the June 2020 issue of Toxicological Sciences include articles on the role of netrin-1 in attenuation of A...
06/01/2020
Volume 175 Issue 2 | Toxicological Sciences | Oxford Academic

Highlights of the June 2020 issue of Toxicological Sciences include articles on the role of netrin-1 in attenuation of Acetaminophen hepatotoxicity, and how a TK6 cell system can be used to detect the genotoxicity of compounds that require metabolic transformation. This issue includes a Contemporary Review on endogenous adverse health effects associated with obesity, as well as a Systematic Review on whether glyphosate is an animal carcinogen. In a #ToxPoint article, brain barrier systems and their role in explaining toxicant-induced neurotoxicities are discussed. There is also an #OpenAcess article on the effects of BHV-0223 on liver toxicity using DILIsym.

Cover illustrations. The binding conformations and interactions of 6-carboxyfl uorescein with organic anion transporter 3 (OAT3). Sixteen amino acids in OAT3 formed hydrogen bonds, π-π interactions or hydrophobic interactions with docked inhibitor molecules. Residues shown as sticks and inhibitor ...

Virtual Exhibitor Recorded Sessions are now available on the SOT Annual Meeting website! These sessions offer educationa...
05/29/2020
ToXchange : Blogs : Now Presenting: Virtual Exhibitor Recorded Sessions

Virtual Exhibitor Recorded Sessions are now available on the SOT Annual Meeting website! These sessions offer educational opportunities for toxicologists by providing toxicology training in specialized areas of interest.

Also, remember to visit the Virtual #ToxExpo and learn more about toxicology services, tools, and solutions that the #2020SOT virtual exhibitors offer.

I am pleased to announce that Exhibitor Recorded Sessions are now accessible on the Annual Meeting website. These recordings of Exhibitor-Hosted Sessions offer educational opportunities for toxicologists in an online format. You are encouraged to access these sessions to gain additional toxicology t...

A National Academies of Sciences, Engineering, and Medicine (NASEM) report addresses the lack of scientific evidence sup...
05/28/2020
There Is a Lack of Evidence, Transparency About Ingredients to Support Use of Compounded Topical Pain Creams, Says New Report

A National Academies of Sciences, Engineering, and Medicine (NASEM) report addresses the lack of scientific evidence supporting the safety and effectiveness of compounded topical pain creams and recommends more research to examine their safety.

Some compounded pain creams include active pharmaceutical ingredients that have been FDA-approved for pain indications, but not topical use. The report recommends improvement of federal and state oversight of safety measures; data collection and surveillance; and training and education for pharmacists and clinicians who compound medications.

#SOTmembers Joyce Tsuji of Exponent Inc. and Carol Wood are members of the NASEM committee that issued the report, while member Howard Maibach of the San Francisco University of California was a reviewer and Past President David Eaton of the University of Washington oversaw the report’s review.

While compounded topical pain creams have become an increasingly popular alternative to oral pain medications and opioids, there is a lack of scientific evidence to support their safety or effectiveness, says a new report from the National Academies of Sciences, Engineering, and Medicine.

A valued part of the Annual Meeting, #ToxExpo allows the toxicology community to exchange ideas and expertise, discover ...
05/22/2020
Society of Toxicology

A valued part of the Annual Meeting, #ToxExpo allows the toxicology community to exchange ideas and expertise, discover career and professional development opportunities, and acquire product and service information—and this year #ToxExpo goes virtual! Exhibitors are featuring their projects, products, and services on the SOT Annual Meeting Website. More exhibitors will continue to be added in the coming weeks.

SOT—Dedicated to Creating a Safer and Healthier World by Advancing the Science and Increasing the Impact of Toxicology.

Lactate produced by Lactobacillus strains could potentially travel to the brain and improve memory, mouse study shows. R...
05/18/2020
Scientists Explore Links Between Genetics, Gut Microbiome and Memory | PNNL

Lactate produced by Lactobacillus strains could potentially travel to the brain and improve memory, mouse study shows.

Researchers from two U.S. Department of Energy national laboratories analyzed the gut microbiome of different strains of mice and found that a species of Lactobacillus, L. reuteri, was associated with improving memory. Researchers tested L. reuteri in a tiny chip that mimics how microbes interact with human intestinal tissue and found that it could potentially enter the bloodstream and travel to the brain.

#SOTmembers David Threadgill of Texas A&M University and Galya Orr of Pacific Northwest National Laboratory - PNNL co-authored this study.

05/12/2020
Hesperos Inc.

SOT TV presents “Hesperos, The Human-On-A-Chip-Company.” Originally prepared for sharing during #2020SOT as a paid promotion, see how human-on-a-chip technology is accelerating drug development and discovery by creating functional aspects of human organs on multi-organ microchips in a serum-free recirculating medium. This testing medium helps Hesperos provide insight on personalized medicine and therapeutic options for rare diseases and advanced cancers.

Hesperos, The Human-On-A-Chip-Company. Hesperos, Inc. is accelerating drug development and discovery by using its Human-on-a-Chip, multi-organ platform to pr...

In his recent message to the SOT membership, SOT President George P. Daston expresses his gratitude to the nearly 1,000 ...
05/11/2020
ToXchange : Blogs : 2020 Abstract Information and a Thank You

In his recent message to the SOT membership, SOT President George P. Daston expresses his gratitude to the nearly 1,000 volunteers for their service to the Society over the last year and especially those who have provided their support, dedication, and leadership in the wake of the cancellation of #2020SOT and creation of the 2020 SOT Virtual Meeting, which will be continuing through June.

If your abstract was accepted for presentation during the 2020 SOT Annual Meeting and ToxExpo, opportunities and guidelines are available to you regarding the science you were planning to share.

Two Contemporary Reviews—one discussing the most common CRISPR technologies and how they are applied in toxicology with ...
05/07/2020
Volume 175 Issue 1 | Toxicological Sciences | Oxford Academic

Two Contemporary Reviews—one discussing the most common CRISPR technologies and how they are applied in toxicology with the other looking at the emergence of magnetic resonance-guided radiotherapy as an alternative to computed tomography-guided therapy—are featured in the May 2020 issue of Toxicological Sciences alongside Tox Spotlight papers on neutrophil gelatinase-associated lipocalin as a biomarker for acute kidney injury and quantitative transcriptional biomarkers of xenobiotic receptor activation for early assessments of drug safety. The issue also includes an editorial commending SOT leadership and staff on their efforts after the cancellation of the SOT 59th Annual Meeting and ToxExpo and an #OpenAccess article on the metabolism, toxicity, and health effects on endogenous metabolism of paracetamol.

05/04/2020
Chemical Insights - An Institute of Underwriters Laboratories

SOT TV presents “Chemical Insights—An Institute of Underwriters Laboratories.” Originally prepared for sharing during #2020SOT as a paid promotion, tour the Chemical Insights laboratories where they are researching chemical compounds, such as those produced by e-cigarettes or through 3D printing, to determine if they pose a health or environmental risk in order to educate the public to help them make informed health decisions.

Chemical Insights: For a Safer, Healthier Tomorrow. There are thousands of chemical compounds in the air we breathe, the water we drink and the products we i...

SOT has added two new #2020SOT Scientific Sessions to the Virtual Meeting Program! In addition to those activities, reme...
05/01/2020
ToXchange : Blogs : More Virtual Sessions Scheduled; Plus, Reminders about ePosters and 2021 Session Proposals

SOT has added two new #2020SOT Scientific Sessions to the Virtual Meeting Program! In addition to those activities, remember that more than 600 ePosters originally scheduled for #2020SOT are available for viewing through May 31:

The 2020 SOT Virtual Meeting is in full swing, with several virtual Continuing Education (CE) courses and Scientific Sessions successfully concluded and a full slate of events scheduled for the coming weeks and months.

Drawing on lab experiments and computer modeling, researchers from Iowa State University studied the toxicity of insecti...
04/30/2020
Study gauges insecticide effects on monarch butterflies • News Service • Iowa State University

Drawing on lab experiments and computer modeling, researchers from Iowa State University studied the toxicity of insecticide ingredients beta‐cyfluthrin (pyrethroid), chlorantraniliprole (anthranilic diamide), chlorpyrifos (organophosphate), and imidacloprid and thiamethoxam (neonicotinoids) on monarch caterpillars at different stages of development. They found some ingredients to be more toxic than others and that some caterpillars are unable to pupate when exposed to neonicotinoid insecticides.

#SOTmembers Joel R. Coats and Niranjana Krishnan of Iowa State University, and Steven P. Bradbury of Steven P Bradbury & Associates LLC co-authored the study.

The study found high monarch larval mortality rates 0 to 15 meters downwind of corn and soybean fields that had been treated with foliar insecticides. However, conservation efforts to help monarch populations rebound call for more than a billion new milkweed plants on agricultural land. Image courte...

04/27/2020
Wisconsin Poison Center - Serving People of Wisconsin

SOT TV presents “Wisconsin Poison Center.” Originally prepared for sharing during #2020SOT as a paid promotion, investigate how poison control centers around the country are interconnected to provide the most up-to-date safety and medical advice through the use of specialists in poison information who come from the fields of nursing, pharmacy, medicine, and toxicology. As shared in the video, medical and clinical toxicologists play a key role in helping educate and provide medical direction to poison control centers.

The Wisconsin Poison Center (WPC) is one of 55 nationally accredited poison centers and is an important resource in Wisconsin’s public health/emergency prepa...

More than 600 Platform and Poster Session presentations originally scheduled for #2020SOT are available as ePosters on t...
04/24/2020
ToXchange : Blogs : Sharing 2020 Research as ePosters and Recognizing Award Recipients

More than 600 Platform and Poster Session presentations originally scheduled for #2020SOT are available as ePosters on the SOT Annual Meeting website and SOT Event App. Also, SOT has created a 2020 ePoster Index PDF (available on the 2020 Annual Meeting website) to assist in browsing the ePosters.

As for Virtual Meeting webinars, SOT Component Groups are hosting virtual meetings to announce their 2020 award recipients and share other information and a new Scientific Session has been added to the Virtual Meeting Program:

This week, I am pleased to share updates related to ePosters and Component Group activities connected with the 2020 SOT Virtual Meeting.

E-cigarette use during pregnancy may harm the respiratory systems of mothers and fetuses, as well as impair other pregna...
04/23/2020
E-Cigarette Use during Pregnancy Not Safe for Mothers and Babies

E-cigarette use during pregnancy may harm the respiratory systems of mothers and fetuses, as well as impair other pregnancy outcomes, researchers find in mouse study.

The study focused on whether nicotine-rich aerosols from e-cigs compromised lung development in mice. The results indicated that fetal lung structure and the Wnt signaling process may be altered.

#SOTmembers Arthur Penn and Alexandra Noel of Louisiana State University; #SOTpostdocmember Ekhtear Hossain of Louisiana University; #SOTstudentmember Rakeysha Ivymaria Pinkston of Southern University and A&M College - Baton Rouge, LA; and Undergraduate Student Affiliate Anusha Zaman of Harvard University co-authored this study.

Rockville, Md. (April 8, 2020)—E-cigarette use during pregnancy could be harmful to the respiratory systems of both mothers and fetuses, according to a new study in the American Journal of Physiology-Lung Cellular and Molecular Physiology. The study, chosen as an APSselect article for April, also ...

“Implementing screening assays that identify functional and structural cardiotoxicity earlier in the drug development pi...
04/22/2020
Targeted Metabolomics-Based Assay Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Identifies Structural and Functional Cardiotoxicity Potential

“Implementing screening assays that identify functional and structural cardiotoxicity earlier in the drug development pipeline has the potential to improve safety and decrease the cost and time required to bring new drugs to market. In this study, a metabolic biomarker-based assay was developed that predicts the cardiotoxicity potential of a drug based on changes in the metabolism and viability of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM). Assay development and testing was conducted in two phases: (1) biomarker identification and (2) targeted assay development. … Metabolite-specific predictive thresholds for identifying the cardiotoxicity potential of a drug were established and optimized for balanced accuracy or sensitivity. When predictive thresholds were optimized for balanced accuracy, the assay predicted the cardiotoxicity potential of 81 drugs with 86% balanced accuracy, 83% sensitivity, and 90% specificity. Alternatively, optimizing the thresholds for sensitivity yields a balanced accuracy of 85%, 90% sensitivity, and 79% specificity. This new hiPSC-CM–based assay provides a paradigm that can identify structural and functional cardiotoxic drugs that could be used in conjunction with other endpoints to provide a more comprehensive evaluation of a drug’s cardiotoxicity potential.” —From the abstract of a ToxSpotlight paper by Palmer et al. in the April 2020 issue of Toxicological Sciences

Abstract. Implementing screening assays that identify functional and structural cardiotoxicity earlier in the drug development pipeline has the potential to im

Study finds that over-the-counter herbal remedy dihydromyricetin (DHM) may be associated with protecting the liver and h...
04/21/2020
Noted hangover remedy DHM has added benefit of protecting the liver

Study finds that over-the-counter herbal remedy dihydromyricetin (DHM) may be associated with protecting the liver and helping prevent alcohol-related harm in mice.

Researchers from the USC School of Pharmacy fed mice alcohol daily, increasing the dose by 39.4 g/kg of ethanol per day, and assessed their livers for injury and stress. “In total, these findings support the utility of DHM as a dietary supplement to reduce ethanol-induced liver injury via changes in lipid metabolism, enhancement of ethanol metabolism and suppressing inflammation responses to promote liver health,” a USC School of Pharmacy News release shares as a quote from the study.

#SOTmember Daryl L. Davies from the University of Southern California was a co-author of the study.

A new USC study has found that herbal hangover cure dihydromyricetin (DHM) may also help people cope with alcoholism and liver damage.

04/20/2020
Institute for Environmental Health Solutions at UNC Gillings School of Global Public Health

SOT TV presents “Institute for Environmental Health Solutions (IEHS) at UNC Gillings School of Global Public Health.” Originally prepared for sharing during #2020SOT as a paid promotion, uncover how since its launch two years ago, the IEHS and #SOTmembers have focused on protecting the most vulnerable populations (for example, pregnant women and children) from harms in the environment while also training and mentoring the next generation of environmental health scientists.

The Institute for Environmental Health Solutions within the Gillings School of Public Health at the University of North Carolina was launched two years ago, ...

NIEHS researchers find that low exposure to the chemical GenX may affect transport proteins at the blood-brain barrier i...
04/16/2020
GenX affects function of proteins that protect the brain (Environmental Factor, April 2020)

NIEHS researchers find that low exposure to the chemical GenX may affect transport proteins at the blood-brain barrier in rats.

Researchers focused on the effects of proteins P-gp, BCRP, and MRP2 in the blood-brain barrier when rats are exposed to chemical GenX. They found that the transport activity of P-gp and BCRP were rapidly reduced but not MRP2. “Our study shows that GenX can change the biology and signaling pathways of these cells,” says #SOTmember Ronald Cannon in an NIEHS article. “GenX exposure could be having major effects on development. …Whether our findings might translate to effects in humans is not known,” Dr. Cannon adds.

#SOTstudentmembers Christopher T. Juberg of the NIEHS and Andrew W. Trexler of Campbell University, as well as #SOTmembers Linda S. Birbnaum and Gabriel A. Knudsen of NIEHS and Alicia C. Richards of SRC, Inc., were co-authors of this study.

New research is part of a larger NIEHS effort to better understand PFAS chemicals.

“Little attention has been paid to the potential impact of paternal marijuana use on offspring brain development. We adm...
04/15/2020
Paternal Δ9-Tetrahydrocannabinol Exposure Prior to Mating Elicits Deficits in Cholinergic Synaptic Function in the Offspring

“Little attention has been paid to the potential impact of paternal marijuana use on offspring brain development. We administered Δ9-tetrahydrocannabinol (THC, 0, 2, or 4 mg/kg/day) to male rats for 28 days. Two days after the last THC treatment, the males were mated to drug-naïve females. We then assessed the impact on development of acetylcholine (ACh) systems in the offspring, encompassing the period from the onset of adolescence (postnatal day 30) through middle age (postnatal day 150) and including brain regions encompassing the majority of ACh terminals and cell bodies. Δ9-Tetrahydrocannabinol produced a dose-dependent deficit in hemicholinium-3 binding, an index of presynaptic ACh activity, superimposed on regionally selective increases in choline acetyltransferase activity, a biomarker for numbers of ACh terminals. … Our studies provide evidence for adverse effects of paternal THC administration on neurodevelopment in the offspring and further demonstrate that adverse impacts of drug exposure on brain development are not limited to effects mediated by the embryonic or fetal chemical environment, but rather that vulnerability is engendered by exposures occurring prior to conception, involving the father as well as the mother.” —From the abstract of a ToxSpotlight paper by Slotkin et al. in the April 2020 issue of Toxicological Sciences

Abstract. Little attention has been paid to the potential impact of paternal marijuana use on offspring brain development. We administered Δ9-tetrahydrocannabi

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General information

Toxicology is the study of the adverse effects of chemical, physical, or biological agents on living organisms and the ecosystem, including the prevention and amelioration of such adverse effects. The Society of Toxicology is dedicated to developing knowledge for the improvement of the health and safety of living beings and the protection of their environment. In attaining the objective, each SOT member must maintain high ethical standards, and to this purpose, this Code of Ethics requires a personal commitment.

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