Society of Toxicology (SOT)

Society of Toxicology (SOT) The Society of Toxicology (SOT) is a professional and scholarly organization of scientists from academic institutions, government, and industry representing the great variety of individuals who practice toxicology in the US and abroad.

The Society promotes the acquisition and utilization of knowledge in toxicology, aids in the protection of public health, facilitates disciplines, and has a strong commitment to education in toxicology and to the recruitment of students and new members into the profession.

The Society promotes the acquisition and utilization of knowledge in toxicology, aids in the protection of public health, facilitates disciplines, and has a strong commitment to education in toxicology and to the recruitment of students and new members into the profession.

Operating as usual

“An acetaminophen (APAP) overdose is the most common cause of acute liver failure in the United States. A hallmark chara...
08/30/2021
Spatial Reconstruction of the Early Hepatic Transcriptomic Landscape After an Acetaminophen Overdose Using Single-Cell RNA-Sequencing

“An acetaminophen (APAP) overdose is the most common cause of acute liver failure in the United States. A hallmark characteristic of APAP hepatotoxicity is centrilobular necrosis. General, innate mechanisms such as lower amounts of GSH and higher cytochrome P450 2e1 expression in pericentral (PC) hepatocytes are known to contribute to the differences in susceptibility to cell injury between periportal (PP) hepatocytes and PC hepatocytes. …Two hours after APAP treatment, we find that PP hepatocytes progress along the APAP stress axis to oxidative stress, before resolving injury due to innate and adaptive mechanisms. However, PC hepatocytes continue along this stress axis as indicated by activation of mitogen-activated protein kinase genes, which is absent in PP hepatocytes. We also identify a population of glutamine synthetase enriched PC hepatocytes in close proximity to the central vein, where a stepwise induction of a stress program culminated in cell death. Collectively, these findings elucidate a molecular sequence of events distinguishing the differential response to APAP exposure between PP and PC hepatocytes and identify a subset of uniquely susceptible PC hepatocytes.” —From the abstract of a ToxSpotlight paper by Umbaugh, Ramachandran, and Jaeschke in the August 2021 issue of Toxicological Sciences

Abstract. An acetaminophen (APAP) overdose is the most common cause of acute liver failure in the United States. A hallmark characteristic of APAP hepatotoxicit

“Regulatory agencies are considering alternative approaches to assessing inhalation toxicity that utilizes in vitro stud...
08/24/2021
New Approach Methodology for Assessing Inhalation Risks of a Contact Respiratory Cytotoxicant: Computational Fluid Dynamics-Based Aerosol Dosimetry Modeling for Cross-Species and In Vitro Comparisons

“Regulatory agencies are considering alternative approaches to assessing inhalation toxicity that utilizes in vitro studies with human cells and in silico modeling in lieu of additional animal studies. In support of this goal, computational fluid-particle dynamics models were developed to estimate site-specific deposition of inhaled aerosols containing the fungicide, chlorothalonil, in the rat and human for comparisons to prior rat inhalation studies and new human in vitro studies. …Using the ICRP clearance model, local retained tissue dose metrics including maximal concentrations and areas under the curve were calculated for each airway region following repeated occupational exposures. These results are directly comparable with benchmark doses from in vitro toxicity studies in human cells leading to estimated human equivalent concentrations that reduce the reliance on animals for risk assessments.” —From the abstract of a ToxSpotlight paper by Corley et al. in the August 2021 issue of Toxicological Sciences

Abstract. Regulatory agencies are considering alternative approaches to assessing inhalation toxicity that utilizes in vitro studies with human cells and in sil

SOT has launched a new membership app! The app allows you to access SOT resources, such as the membership directory, blo...
08/19/2021
SOT Launches New Membership App

SOT has launched a new membership app! The app allows you to access SOT resources, such as the membership directory, blogs, and more without the need to go through the SOT or ToXchange websites. The new app is connected to your membership profile and the ToXchange online communities, discussions, libraries, and announcements, allowing you to interact with your friends and colleagues more quickly.

Download it now in the Apple App and Google Play stores!

A new SOT membership app—available now in the Apple App and Google Play stores—allows you to access SOT resources, such as the membership directory, blogs, and more without the need to go through the SOT or ToXchange websites.

The SOT Association of Scientists of Indian Origin (ASIO) Special Interest Group acts as a scientific and educational so...
08/17/2021
SOT Special Interest Group Spotlight: Association of Scientists of Indian Origin

The SOT Association of Scientists of Indian Origin (ASIO) Special Interest Group acts as a scientific and educational society that establishes open channels of communication among toxicologists of Indian origin. ASIO members collectively work toward building a supportive environment for young professionals to seek advice and achieve new heights in their professional endeavors.

As a Special Interest Group within SOT, ASIO aims to work closer together to develop the next generation of toxicology leaders.

The Association of Scientists of Indian Origin (ASIO), an SOT Special Interest Group (SIG), is an organization of more than 200 active members who are scientists from academia, industry, and nonprofit organizations. The group acts as a scientific and educational society that establishes open channel...

Tox Spotlight articles in the August 2021 issue of Toxicological Sciences include research on computational fluid-partic...
08/12/2021
Volume 182 Issue 2 | Toxicological Sciences | Oxford Academic

Tox Spotlight articles in the August 2021 issue of Toxicological Sciences include research on computational fluid-particle dynamics models that measure specific deposition of inhaled aerosols containing fungicide or chlorothalonil in rats and humans, as well as research using single-cell RNA-sequencing to provide the first reconstruction of transcriptomic acetaminophen liver lobule. The issue also includes a Contemporary Review on how a fruit fly called Drosophila may provide a platform for mechanistic dissection and drug discovery. This issue also includes a Letter to the Editor by two SOT members stating their opinion on promoting diversity, equity, and inclusion. Discover the latest impactful research in toxicology in the August 2021 issue of ToxSci: Your science. Your journal.

Oxford University Press is a department of the University of Oxford. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide

Registration and Housing are officially open for #2022SOT and #ToxExpo! Join SOT Mar. 27–31, in San Diego, California, t...
08/11/2021
2022 SOT Annual Meeting and ToxExpo

Registration and Housing are officially open for #2022SOT and #ToxExpo! Join SOT Mar. 27–31, in San Diego, California, to experience 58 Scientific Sessions, 12 Continuing Education courses, and 60+ social events and interact with 250+ exhibitors that will be sharing the latest products and technology in toxicology.

You can register and book housing through the newly launched 2022 Annual Meeting website.

Join thousands of scientists and researchers for the world’s preeminent toxicology conference, March 27–31, 2022, in San Diego, CA. Explore options for registration, travel, hotels, awards, and more.

“The ability to deduce carcinogenic potential from subchronic, repeat dose rodent studies would constitute a major advan...
07/29/2021
CarcSeq Measurement of Rat Mammary Cancer Driver Mutations and Relation to Spontaneous Mammary Neoplasia

“The ability to deduce carcinogenic potential from subchronic, repeat dose rodent studies would constitute a major advance in chemical safety assessment and drug development. This study investigated an error-corrected NGS method (CarcSeq) for quantifying cancer driver mutations (CDMs) and deriving a metric of clonal expansion predictive of future neoplastic potential. CarcSeq was designed to interrogate subsets of amplicons encompassing hotspot CDMs applicable to a variety of cancers. …Mutants in the mammary-specific target of the most tumor-sensitive strain (Sprague Dawley) showed the greatest nonsynonymous/synonymous mutation ratio, indicative of positive selection consistent with clonal expansion. For the mammary-specific target (Hras, Pik3ca, and Tp53 amplicons), median absolute deviation correlated with percentages of rats that develop spontaneous mammary neoplasia at 104 weeks (Pearson r = 1.0000, 1-tailed p = .0010). Therefore, this study produced evidence CarcSeq analysis of spontaneously occurring CDMs can be used to derive an early metric of clonal expansion relatable to long-term neoplastic outcome.” —From the abstract of a ToxSpotlight paper by McKim et al. in the July 2021 issue of Toxicological Sciences

Abstract. The ability to deduce carcinogenic potential from subchronic, repeat dose rodent studies would constitute a major advance in chemical safety assessmen

“The unique physicochemical properties of carbon nanomaterials and their ever-growing utilization generate a serious con...
07/27/2021
Carbon Nanotube Exposure Triggers a Cerebral Peptidomic Response: Barrier Compromise, Neuroinflammation, and a Hyperexcited State

“The unique physicochemical properties of carbon nanomaterials and their ever-growing utilization generate a serious concern for occupational risk. Pulmonary exposure to these nanoparticles induces local and systemic inflammation, cardiovascular dysfunction, and even cognitive deficits. Although multiple routes of extrapulmonary toxicity have been proposed, the mechanism for and manner of neurologic effects remain minimally understood. Here, we examine the cerebral spinal fluid (CSF)–derived peptidomic fraction as a reflection of neuropathological alterations induced by pulmonary carbon nanomaterial exposure. …Identified MWCNT-responsive peptides depicted a mechanism involving aberrant fibrinolysis (fibrinopeptide A), blood-brain barrier permeation (homeobox protein A4), neuroinflammation (transmembrane protein 131L) with reactivity by astrocytes and microglia, and a pro-degradative (signal transducing adapter molecule, phosphoglycerate kinase), antiplastic (AF4/FMR2 family member 1, vacuolar protein sorting-associated protein 18) state with the excitation-inhibition balance shifted to a hyperexcited (microtubule-associated protein 1B) phenotype. Overall, the significant pathologic changes observed were consistent with early neurodegenerative disease and were diagnostically reflected in the CSF peptidome.” —From the abstract of a ToxSpotlight paper by Mostovenko et al. in the July 2021 issue of Toxicological Sciences

Abstract. The unique physicochemical properties of carbon nanomaterials and their ever-growing utilization generate a serious concern for occupational risk. Pul

The July 2021 issue of Toxicological Sciences features a Tox Spotlight article on how pulmonary exposure to carbon nanom...
07/22/2021
Volume 182 Issue 1 | Toxicological Sciences | Oxford Academic

The July 2021 issue of Toxicological Sciences features a Tox Spotlight article on how pulmonary exposure to carbon nanomaterials may trigger a cerebral peptidomic response and another on how CarcSeq analysis of spontaneously occurring cancer-driving mutations can be used for deriving a metric of clonal expansion related to long-term neoplastic outcome. Also in the issue, a Contemporary Review focuses on the role of the aryl hydrocarbon receptor on embryonic development, tissue repair, and maintenance of stemness. Discover the latest impactful research in toxicology in the July 2021 issue of ToxSci: Your science. Your journal.

Oxford University Press is a department of the University of Oxford. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide

Apply for a #2022SOT Award for research and training in toxicology by October 9! SOT is pleased to partner with supporti...
07/15/2021
Ilona Jaspers' Blog - SOT

Apply for a #2022SOT Award for research and training in toxicology by October 9!

SOT is pleased to partner with supporting companies to offer five Supported Awards that deliver grants and fellowships to deserving investigators to advance their research or enable training activities.

All Supported Awards have their own eligibility requirements, so applicants should read the criteria for each award closely when preparing application materials.

Lists all of the the blog entries

SOT TV presents “Team Science at Its Best.” Students in the Molecular Toxicology Interdepartmental Program at UCLA share...
07/14/2021
The Molecular Toxicology Interdepartmental Program at UCLA

SOT TV presents “Team Science at Its Best.” Students in the Molecular Toxicology Interdepartmental Program at UCLA share stories of the friendly, collaborative environment on the Westwood campus and the fascinating research that’s underway in this paid film produced by WebsEdge Medicine.

Team Science At Its Best.In its 17th year at UCLA, the interdepartmental Ph.D. program in Molecular Toxicology is now something really special. Students in a...

The #2022SOT Awards season has begun! You are encouraged to nominate or apply for #SOTAwards by October 9. The Society c...
07/12/2021
Search for SOT Awards

The #2022SOT Awards season has begun! You are encouraged to nominate or apply for #SOTAwards by October 9.

The Society confers hundreds of awards throughout the year to support and honor distinguished toxicologists. As SOT plans for its Annual Meeting in San Diego in March, the Society especially looks forward to bestowing many of these honors in person during the 2022 Awards Ceremony.

Explore the nomination and application information for Society’s numerous award opportunities that recognize outstanding scientists across academic and career levels.

SOT TV presents “Protection through Sound Science.” The Toxicology, Risk Assessment, and Research Division of the Texas ...
07/09/2021
Texas Commission on Environmental Quality Toxicology, Risk Assessment, and Research Division

SOT TV presents “Protection through Sound Science.” The Toxicology, Risk Assessment, and Research Division of the Texas Commission on Environmental Quality (TCEQ) uses sound science and the principles of protectiveness, responsiveness, and vigilance to apply toxicology and risk assessment methods that ensure the protection of the people and natural resources in Texas. Learn more about the work being done by the TCEQ in this paid film produced by WebsEdge Medicine.

Protection Thru Sound Science. Texas residents want a vibrant economy, and they also want their beautiful natural resources protected. Finding that balance i...

SOT TV presents “Careful Research to Refine, Reduce, and Replace Animals in Experiments.” Learn about the German Centre ...
06/30/2021
German Centre for the Protection of Laboratory Animals (Bf3R)

SOT TV presents “Careful Research to Refine, Reduce, and Replace Animals in Experiments.” Learn about the German Centre for the Protection of Laboratory Animals, part of the German Federal Institute for Risk Assessment, and its aim to push non-animal research forward, as well as influence public policy, to improve the science supporting products used every day in this paid film produced by WebsEdge Medicine.

For decades, the use of animals in research has been guided by the three Rs -Replacement, Reduction and Refinement – but it takes careful research to find wa...

“Bisphenol F (BPF) is increasingly substituting bisphenol A in manufacturing polycarbonates and consumer products. The c...
06/28/2021
Bisphenol F Exposure in Adolescent Heterogeneous Stock Rats Affects Growth and Adiposity

“Bisphenol F (BPF) is increasingly substituting bisphenol A in manufacturing polycarbonates and consumer products. The cardiometabolic effects of BPF in either humans or model organisms are not clear, and no studies to date have investigated the role of genetic background on susceptibility to BPF-induced cardiometabolic traits. The primary goal of this project was to determine if BPF exposure influences growth and adiposity in male N:NIH heterogeneous stock (HS) rats, a genetically heterogeneous population. …BPF-exposed rats showed significantly increased body growth and abdominal adiposity, risk factors for cardiometabolic disease. Urine output was increased in BPF-exposed rats, driving a trend in increased creatinine clearance. We also report the first relationship between a bisphenol metabolizing enzyme and a bisphenol-induced phenotype. Preliminary heritability estimates of significant phenotypes suggest that BPF exposure may alter trait variation. These findings support BPF exposure as a cardiometabolic disease risk factor...[in rats] .” —From the abstract of a ToxSpotlight paper by Wagner et al. in the June 2021 issue of Toxicological Sciences

Abstract. Bisphenol F (BPF) is increasingly substituting bisphenol A in manufacturing polycarbonates and consumer products. The cardiometabolic effects of BPF i

SOT TV presents “Superior Human Skin Models.” Phenion, a brand from Henkel, aims to assure that human skin tissues model...
06/24/2021
Phenion, Henkel AG

SOT TV presents “Superior Human Skin Models.” Phenion, a brand from Henkel, aims to assure that human skin tissues models are developed, produced, and made available. Learn about their approach and how Henkel provides unlimited access to its technology in this paid film produced by WebsEdge Medicine.

Phenion – The Henkel brand for superior human skin models.Phenion, a brand from Henkel, stands for the development of alternative test methods and offers mor...

“A new safety testing paradigm that relies on gene expression biomarker panels was developed to easily and quickly ident...
06/21/2021
Universal Toxicity Gene Signatures for Early Identification of Drug-Induced Tissue Injuries in Rats

“A new safety testing paradigm that relies on gene expression biomarker panels was developed to easily and quickly identify drug-induced injuries across tissues... . Here, we describe the development, qualification, and implementation of gene expression signatures that diagnose tissue degeneration/necrosis for use in early rat safety studies. …Similar performance was observed across a set of 15 studies for pancreas, gastrointestinal tract, bladder, and te**es. Bundled together, we have incorporated these tissue signatures into a 4-day rat study, providing a rapid assessment of commonly seen compound liabilities to guide selection of lead candidates without the necessity to perform time-consuming histopathologic analyses.” —From the abstract of a ToxSpotlight paper by Glaab et al. in the June 2021 issue of Toxicological Sciences

Abstract. A new safety testing paradigm that relies on gene expression biomarker panels was developed to easily and quickly identify drug-induced injuries acros

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General information

Toxicology is the study of the adverse effects of chemical, physical, or biological agents on living organisms and the ecosystem, including the prevention and amelioration of such adverse effects. The Society of Toxicology is dedicated to developing knowledge for the improvement of the health and safety of living beings and the protection of their environment. In attaining the objective, each SOT member must maintain high ethical standards, and to this purpose, this Code of Ethics requires a personal commitment.

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