Society of Toxicology (SOT)

Society of Toxicology (SOT) The Society of Toxicology (SOT) is a professional and scholarly organization of scientists from academic institutions, government, and industry representing the great variety of individuals who practice toxicology in the US and abroad.

The Society promotes the acquisition and utilization of knowledge in toxicology, aids in the protection of public health, facilitates disciplines, and has a strong commitment to education in toxicology and to the recruitment of students and new members into the profession.

The Society promotes the acquisition and utilization of knowledge in toxicology, aids in the protection of public health, facilitates disciplines, and has a strong commitment to education in toxicology and to the recruitment of students and new members into the profession.

Mission: The Society of Toxicology is the leading organization dedicated to creating a safer and healthier world by advancing the science of toxicology.

Operating as usual

“Using a chimeric mouse humanized liver model, we provided evidence that human hepatocytes are refractory to the mitogen...
10/23/2020
Comparison of the Hepatic Effects of Phenobarbital in Chimeric Mice Containing Either Rat or Human Hepatocytes With Humanized Constitutive Androstane Receptor and Pregnane X Receptor Mice

“Using a chimeric mouse humanized liver model, we provided evidence that human hepatocytes are refractory to the mitogenic effects of rodent constitutive androstane receptor (CAR) activators. To evaluate the functional reliability of this model, the present study examined mitogenic responses to phenobarbital (PB) in chimeric mice transplanted with rat hepatocytes, because rats are responsive to CAR activators. …The results of this study demonstrate clear differences in the effects of PB on hepatocyte replicative DNA synthesis and global gene expression between human hepatocytes of chimeric mice and hCAR/hPXR mice, suggesting that the chimeric mouse model is relevant to humans for studies on the hepatic effects of rodent CAR activators whereas the hCAR/hPXR mouse is not.” —From the abstract of a ToxSpotlight paper by Yamada et al. in the October 2020 issue of Toxicological Sciences

Abstract. Using a chimeric mouse humanized liver model, we provided evidence that human hepatocytes are refractory to the mitogenic effects of rodent constitut

Two Contemporary Reviews—one discussing the biology of microtubule cytoskeleton in supporting spermatogenesis with the o...
10/15/2020
Volume 177 Issue 2 | Toxicological Sciences | Oxford Academic

Two Contemporary Reviews—one discussing the biology of microtubule cytoskeleton in supporting spermatogenesis with the other looking at the regulatory aspects of registration of pesticides in Brazil—are featured in the October 2020 issue of Toxicological Sciences. One of the Tox Spotlight papers discusses the mitogenic responses to phenobarbital on hepatocyte replicative DNA synthesis and global gene expression between human hepatocytes of chimeric mice and humanized CAR and pregnane X receptor mice. Another Tox Spotlight paper reveals the effects of arsenic exposure on skeletal muscle metabolism and composition. Read the full issue now.

Cover illustrations. Store-operated calcium entry (SOCE)-mediated autophagy-related pathway in thyrocytes. PCB118 activates SOCE channels by binding STIM1 to ORAI1 and promotes calcium infl ux, triggering the TUBB3/ DAPK2/ MRLC/ATG9A pathway and initiation of thyrocyte autophagy. From Wang et al. pp...

“I was really excited and grateful when I learned that I was the recipient of this award. It is a prestigious honor whic...
10/07/2020
2020 Endowment Fund Award Recipients

“I was really excited and grateful when I learned that I was the recipient of this award. It is a prestigious honor which will benefit me tremendously in my scientific pursuit. … It will be a great opportunity to interact with renowned scientists working in the field of toxicology and I will be hugely benefited from the discussions, feedback, and new ideas. Furthermore, I will be able to incorporate these new ideas while finalizing my upcoming original research articles. Recognition from this award will further motivate me to pursue—with high standard of excellence—my research and achieve my career goals.”—2020 Harihara Mehendale Association of Scientists of Indian Origin Student Award Fund award recipient Prathyusha Bagam, Southern University and A&M College - Baton Rouge, LA

Ms. Bagam works in the field of pulmonary immunotoxicity with a focus on inhalation toxicology. She is interested in determining the effect of cigarette smoke (active and passive smoking) on the mechanism(s) associated with protein homeostasis.

This award is supported by the SOT Endowment Fund and encourages graduate students and postdoctoral fellows, who are individuals of Indian origin, to pursue advanced studies in the field of toxicology.

Most of the SOT Endowment Funds sponsor awards designed to encourage toxicology research and toxicologists. Meet the recipients of the 2020 Endowment Fund Awards.

“Polychlorinated biphenyls (PCBs) are ubiquitously detected and have been linked to metabolic diseases. Gut microbiome i...
09/30/2020
Gut Microbiome Critically Impacts PCB-induced Changes in Metabolic Fingerprints and the Hepatic Transcriptome in Mice

“Polychlorinated biphenyls (PCBs) are ubiquitously detected and have been linked to metabolic diseases. Gut microbiome is recognized as a critical regulator of disease susceptibility; however, little is known [about] how PCBs and gut microbiome interact to modulate hepatic xenobiotic and intermediary metabolism. We hypothesized the gut microbiome regulates PCB-mediated changes in the metabolic fingerprints and hepatic transcriptome. Ninety-day-old female conventional and germ-free mice were orally exposed to the Fox River Mixture (synthetic PCB mixture, 6 or 30 mg/kg) or corn oil (vehicle control, 10 ml/kg), once daily for three consecutive days. ... Our findings demonstrate that habitation of the gut microbiota drives PCB-mediated hepatic responses. Our study adds knowledge of physiological response differences from PCB exposure and considerations for further investigations for gut microbiome-dependent therapeutics.” —From the abstract of a ToxSpotlight paper by Lim et al. in the September 2020 issue of Toxicological Sciences

Abstract. Polychlorinated biphenyls (PCBs) are ubiquitously detected and have been linked to metabolic diseases. Gut microbiome is recognized as a critical reg

“It is a reaction full of feelings of emotion, joy, and gratitude. The emotion is linked, on the one hand, to the fact t...
09/29/2020
2020 Endowment Fund Award Recipients

“It is a reaction full of feelings of emotion, joy, and gratitude. The emotion is linked, on the one hand, to the fact that I come from very far (origin Benin and academic route) and, on the other hand, to the fact that the awards of SOT are very competitive. I dreamed of this since the beginning of my doctoral training at the Université de Montréal without being sure to get it one day. . . . My gratitude also to the members of the SOT Biological Modeling Specialty Section, who recognized in my work a great merit. This award encourages me to strengthen my skills and to continue research in toxicology as much as possible, with methods of computational toxicology, with a view to contribute to reduce or avoid the use of laboratory animals.”
—2020 Perry J. Gehring Biological Modeling Student Award Fund recipient Honesty Tohon, Université de Montréal

Mr. Tohon’s doctoral research focuses on the study of the impact of multi-route chemical co-exposures (case of volatile organic compounds [VOCs]) on the interindividual variability of the fate of individual substances in the human body.

This award is supported by the SOT Endowment Fund and encourages students to pursue careers that utilize biological modeling to advance the science of toxicology.

Most of the SOT Endowment Funds sponsor awards designed to encourage toxicology research and toxicologists. Meet the recipients of the 2020 Endowment Fund Awards.

“Feline McDonough Sarcoma-like tyrosine kinase 3 (FLT3), a tyrosine-protein kinase involved in hematopoiesis, is detecta...
09/28/2020
Nonclinical Safety Assessment of AMG 553, an Investigational Chimeric Antigen Receptor T-Cell Therapy for the Treatment of Acute Myeloid Leukemia

“Feline McDonough Sarcoma-like tyrosine kinase 3 (FLT3), a tyrosine-protein kinase involved in hematopoiesis, is detectable on the cell surface of approximately 80% of leukemia isolates from adult patients with acute myeloid leukemia (AML). AMG 553 is an investigational chimeric antigen receptor (CAR) T-cell immunotherapy for the treatment of AML. FLT3 expression analysis and in vitro and in vivo studies were leveraged to evaluate the nonclinical safety of AMG 553. Cynomolgus monkeys administered autologous anti-FLT3 CAR T cells demonstrated no evidence of CAR T-cell-mediated toxicity, expansion, or persistence, likely due to restricted cell surface FLT3 protein expression in healthy animals. This highlights the limited value of such in vivo studies for safety assessment of the CAR T-cell modality when directed against a target with restricted expression. To complement these studies and directly evaluate the potential toxicities of eliciting T-cell-mediated cytotoxicity against cells with surface expression of FLT3 protein in vivo, data from cynomolgus monkey toxicology studies with two bispecific T-cell engager molecules targeting FLT3 were leveraged; findings were consistent with the targeted killing of bone marrow cells expressing cell surface FLT3. Potential AMG 553-induced cytotoxicity was assessed against a wide range of normal human primary cells and cell lines; cytotoxicity was observed against FLT3-positive AML cell lines and a percentage of primary bone marrow CD34+ cells. In conclusion, the nonclinical safety data suggest that AMG 553 can target FLT3 protein on AML cells, whereas only affecting a percentage of normal hematopoietic stem and progenitor cells, supporting clinical development.” —From the abstract of a ToxSpotlight paper by Karbowski et al. in the September 2020 issue of Toxicological Sciences

Abstract. Feline McDonough Sarcoma-like tyrosine kinase 3 (FLT3), a tyrosine-protein kinase involved in hematopoiesis, is detectable on the cell surface of app

“Chronic hexavalent chromium [Cr(VI)] exposure causes lung cancer and other types of cancer; however, the mechanism of C...
09/25/2020
Positive Feedback Loop Between c-Myc Upregulation, Glycolytic Shift, and Histone Acetylation Enhances Cancer Stem Cell-like Property and Tumorigenicity of Cr(VI)-transformed Cells

“Chronic hexavalent chromium [Cr(VI)] exposure causes lung cancer and other types of cancer; however, the mechanism of Cr(VI) carcinogenesis remains to be clearly defined. ... This study was performed to investigate the potential role and mechanism of metabolism dysregulation in Cr(VI) carcinogenesis. It was found that Cr(VI)-transformed cells display glycolytic shift, which depends on the upregulation of c-Myc. The glycolytic shift in Cr(VI)-transformed cells led to increased production of acetyl coenzyme A (acetyl-CoA) and elevation of histone acetylation. This, in turn, upregulated the expression of an acetyl-CoA producing key enzyme ATP citrate lyase and c-Myc, forming a positive feedback loop between the upregulation of c-Myc expression, glycolytic shift, and increased histone acetylation. It was further determined that glucose depletion not only reverses the glycolytic shift in Cr(VI)-transformed cells, but also significantly reduces their growth, CSC-like property, and tumorigenicity. These findings indicate that glycolytic shift plays an important role in maintaining malignant phenotypes of Cr(VI)-transformed cells, suggesting that metabolism dysregulation is critically involved in Cr(VI) carcinogenesis.” —From the abstract of a ToxSpotlight paper by Clementino et al. in the September 2020 issue of Toxicological Sciences

Abstract. Chronic hexavalent chromium [Cr(VI)] exposure causes lung cancer and other types of cancer; however, the mechanism of Cr(VI) carcinogenesis remains t

As an organization whose mission is to protect and improve public health, SOT leadership has decided that the 2021 SOT A...
09/23/2020
2021 SOT Annual Meeting and ToxExpo

As an organization whose mission is to protect and improve public health, SOT leadership has decided that the 2021 SOT Annual Meeting and ToxExpo will be held as a virtual event. By using state-of-the-art technology, SOT will present a full agenda of Symposia, Workshops, Continuing Education Courses, Poster Sessions, and exhibits as part of its Virtual Meeting in March 2021. For more details, read the announcement by SOT President George P. Daston, PhD, that is posted to the SOT Annual Meeting website.

Join thousands of scientists and researchers for the Virtual 2021 SOT Annual Meeting. Explore options for registration, awards, and more.

Celebrate postdocs and their accomplishments in research and scientific discovery during National Postdoc Appreciation W...
09/21/2020
George Daston's Blog - SOT

Celebrate postdocs and their accomplishments in research and scientific discovery during National Postdoc Appreciation Week, September 21–25, 2020.

“SOT postdoctoral scholars are an integral part of the SOT community—through their individual contributions and those of the collective postdoc family. During National Postdoc Appreciation Week 2020, I am pleased to represent SOT and Council in extending our appreciation for their determined effort in becoming the future leaders in toxicology,” said SOT President George Daston in a SOT Communique Blog Post.

Lists all of the the blog entries

Last month, the SOT Presidential Chain held a focus group with Black and Latinx members to discuss diversity and inclusi...
09/18/2020

Last month, the SOT Presidential Chain held a focus group with Black and Latinx members to discuss diversity and inclusion within SOT activities and programs. SOT looks forward to continuing the conversation during a Society-wide Town Hall on Sept. 25 at 1:00 PM. Registration is open for members.

Tox Spotlight articles in the September 2020 issue of Toxicological Sciences include research on the potential role and ...
09/17/2020
Volume 177 Issue 1 | Toxicological Sciences | Oxford Academic

Tox Spotlight articles in the September 2020 issue of Toxicological Sciences include research on the potential role and mechanism of metabolism dysregulation in Cr(VI) carcinogenesis; how PCBs and gut microbiome interact to modulate hepatic xenobiotic and intermediary metabolism; and a study of the potential toxicities of eliciting T-cell-mediated cytotoxicity against cells with surface expression of FLT3 protein in vivo. A Contemporary Review that discusses clinical implications and possible alterations in treatment protocols following organophosphate exposure is also featured in the issue. Discover the latest impactful research in toxicology in the September 2020 issue of ToxSci: Your science. Your journal.

Cover illustrations. An in vitro trans-epithelial exposure model showing the difference between direct and trans-epithelial exposures. With typical trans-epithelial exposure models, bronchial epithelial cells are directly exposed to diesel exhaust particulates (DEP). The trans-epithelial exposure mo...

Researchers find that fine particles of air pollution, called PM2.5, may increase the risk of developing cardiometabolic...
09/14/2020
Home | University Hospitals Newsroom

Researchers find that fine particles of air pollution, called PM2.5, may increase the risk of developing cardiometabolic diseases in mouse study.

In the study, researchers observed three groups of mice: a control group receiving clean air, a group exposed to polluted air, and a group fed a high-fat diet. The researchers found that the group exposed to polluted air and the group that was fed a high-fat diet showed similar conditions, such as insulin resistance and an abnormal metabolism. The research team plans to meet with the National Institutes of Health (NIH) to discuss conducting clinical trials comparing heart health and the level of environmental air pollution.

#SOTmember Shyam Biswal of Johns Hopkins Bloomberg School of Public Health of Public Health was a co-author of this study.

University Hospitals Newsroom - the official site for press releases, photos, video, audio, pr contact information, presskits and more.

“I was excited and encouraged to know that the work I find interesting and meaningful is also of interest to other top s...
09/10/2020
2020 Endowment Fund Award Recipients

“I was excited and encouraged to know that the work I find interesting and meaningful is also of interest to other top scientists in my field.”—2020 Environmental Carcinogenesis Research Fellowship Fund award recipient Tasha Thong, University of Michigan

Ms. Thong's research project is focused on uncovering the biological basis for racial disparities in breast cancer between African American and European American women. At every age, African American women have worse breast cancer outcomes, yet the biological basis for this is still unknown. Ms. Thong believes that stem cells play a crucial role in carcinogenesis, and she cultured normal breast tissue from healthy volunteers in order to characterize differences between mammary stem cells from African American and European American women. Thus far, she has used single-cell RNA sequencing to characterize the transcriptomic profiles of her samples, and her future work will involve epigenetic profiling as well as challenging the samples with exposure to environmental toxicants.

This award is supported by the SOT Endowment Fund and recognizes high-quality abstracts representing research related to environmental carcinogenesis.

Most of the SOT Endowment Funds sponsor awards designed to encourage toxicology research and toxicologists. Meet the recipients of the 2020 Endowment Fund Awards.

Researchers find that wearing a gaiter face mask may protect against the spread of exhaled droplets in a manner comparab...
09/09/2020
WVU Today | Gaiters do no harm: WVU toxicologists find coverings help contain the spread of exhaled droplets

Researchers find that wearing a gaiter face mask may protect against the spread of exhaled droplets in a manner comparable to common over-the-ear cloth masks.

“...since the mask is close to the mouth, high-velocity flow events from the mask user, such as coughing or talking, will cause many expelled droplets to impact the inner surface of the mask. Further, any mouth covering dissipates and spreads the flow velocity from the user, which will cause aerosols to travel shorter distances,” said West Virginia University’s iTOX senior research engineer Travis Goldsmith in a West Virginia University article.

#SOTmember Timothy Nurkiewicz of West Virginia University School Of Medicine led the iTOX study.

Experts with the West Virginia University Center for Inhalation Toxicology found that – assuming it’s a good fit - a gaiter will, despite recent reports, provide a respiratory containment of exhaled droplets comparable to a common over-the-ear cloth mask.

An observational study finds that teenagers and young adults who use e-cigarettes may be five times more likely to be di...
09/04/2020
A New Survey Links Vaping to Higher Covid-19 Risk

An observational study finds that teenagers and young adults who use e-cigarettes may be five times more likely to be diagnosed with #COVID19.

Data was gathered through an online survey that asked respondents whether they had used e-cigarettes; whether they had used them in the last 30 days; whether they had been tested for COVID-19; and whether their results came back positive. Researchers found that teens and young adults who had used e-cigarettes in the last 30 days were more likely to get tested as well as to test positive.

“There’s been a consensus that vaping and the use of e-cigarettes causes a suppression of respiratory immune responses,” said #SOTmember and deputy director of the The University of North Carolina at Chapel Hill's Center for Environmental Medicine, Asthma, and Lung Biology, Ilona Jaspers, in the WIRED article on this study.

A Stanford University report shows that teens and young adults who use e-cigarettes are five to seven times more likely to test positive for the virus.

Address

1821 Michael Faraday Dr, Ste 300
Reston, VA
20190

General information

Toxicology is the study of the adverse effects of chemical, physical, or biological agents on living organisms and the ecosystem, including the prevention and amelioration of such adverse effects. The Society of Toxicology is dedicated to developing knowledge for the improvement of the health and safety of living beings and the protection of their environment. In attaining the objective, each SOT member must maintain high ethical standards, and to this purpose, this Code of Ethics requires a personal commitment.

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Thursday 08:30 - 17:00
Friday 08:30 - 17:00

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(703) 438-3115

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