Superlative Formulas

10/19/2023

SUPERLATIVE FORMULAS: REVAMP (also comes in 20:1 concentration)

HEALTH BENEFITS:
Health benefits of this formula based off studies conducted on these ingredients and observations may include but not limited to: enhanced complexion, facilitating hair growth, increased endurance, decreased fatigue, abolished stress, greater focus, anti-muscle catabolism, anti-mutagenic, anti-thrombotic, increased energy, etc.

INGREDIENTS:
1. Polyrhachis Ant
2. Ginseng Panax
3. Ginseng American
4. Reishi Mushroom
5. Cnidium Seed
6. Schizandra
7. He Shou Wu
8. Eucommia
9. Deer Antler
10. Cordyceps Mushroom
11. Astragalus
12. Gynostemma
13. Dendrobium
14. Ajuga Turkestanika
15. Mucuna pruriens
16. Chaga Mushroom
17. Pine Pollen
18. Shilajit
19. Tongkat Ali
20. Cistanche
21. Rhemania
22. Nettle Root
23. Rhodiola Root
24. Maca Root
25. Lions Mane Mushroom
26. Celastrus Seed
27. Cyanotis arachnoidea
28. Horsetail
29. Agarikon Mushroom
30. Licorice Root
31. Reishi Spores
32. Asparagus Root
33. Turkey Tail Mushroom
34. Cynomorium Root
35. Maral Root
36. Tribulus Terrestris
37. Angelica Root
38. Pine Needle
39. Star Anise
40. Fennel Seed
41. Epimedium
42. Eleuthero root

Link to page: https://superlativeformulas.com/products/superlative-50-1?variant=42432256180406

10/02/2023

SUPERLATIVE FORMULAS: SHILAJIT (standardized at 50% fulvic acid).
Shilajit is a fulvic acid rich resinous substance that is harvested in the Himalayan mountains, offering a plethora of possible beneficial effects on the body:
1.) Enhancing cognition
2.) Immunomodulator
3.) Anti-ulcerogenic
4.) Adaptogenic/Anti stress
5.) Lowering blood sugar
6.) Antioxidant
7.) Electrolytes/minerals
8.) Increasing bioavailability of other substances.
9.) Analgesic
10.) Reproductive system
11.) Etc..
Studies highlighting the incredible health benefits that Shilajit may provide- https://superlativeformulas.com/pages/SHILAJIT

SUPERLATIVE FORMUALS: SHILAJIT extract is standardized at a highly potent 50% fulvic acid content!
Around 300 (1/8th tsp) servings in 100g bag! $75.
Message me for additional information.

Bible Directions to Heaven: https://www.youtube.com/watch?app=desktop&v=m9Rmm7Mqt74...

10/02/2023

SUPERLATIVE FORMULAS: PINE POLLEN (Raw Wild Harvested Cracked Cell Wall)

Pine pollen is a "youth powder" that may provide beneficial effects for the nails/skin/hair, hormone balance, libido, testosterone, energy, etc.
Multiple studies on the incredible health benefits that pine pollen may provide-https://superlativeformulas.com/pages/PINE-POLLEN

$65 for 250g bag (Approximately 80+ servings).
Message me if you have any questions.

Bible Directions to Heaven: https://www.youtube.com/watch?app=desktop&v=m9Rmm7Mqt74...

01/05/2023

FEATURED IN SUPERLATIVE FORMULAS: ANALGESIC (200:1 concentration)

Evaluation of Analgesic and Antioxidant Potential of the Leaves of Curcuma alismatifolia Gagnep.

Abstract:
“In the present study, the antioxidant and analgesic potential of the 80% methanol extract of the leaves of Curcuma alismatifolia Gangnep was evaluated. The extract was investigated for its antioxidant activity using lipid peroxidation, total antioxidant capacity and reducing power assays. The extract showed significant antioxidant activities in lipid peroxidation assay compared to the standard antioxidant in a dose dependent manner. In lipid peroxidation assay, the IC50 value was found to be 122.43μg/mL while the IC50 value for the reference ascorbic acid was 147.87μg/ml. Moreover, Curcuma alismatifolia extract showed strong total antioxidant capacity and good reducing power. The analgesic activity was evaluated for its central and peripheral pharmacological actions using tail immersion method and acetic acid-induced writhing test in mice respectively. The extract, at the dose of 250 and 500 mg/kg, produced a significant (p < 0.05-0.001) increase in pain threshold in tail immersion methods in a dose dependent manner. In acetic acid-induced writhing test the extract, at a dose of 500 mg/kg, showed a maximum of 60.5% inhibition (p < 0.001) of writhing reaction compared to the reference drug diclofenac-sodium (75.0%). All experimental results suggest the use of this plant for the treatment of pain and inflammatory disorder.” https://www.banglajol.info/index.php/sjps/article/view/1779

SUPERLATIVE FORMULAS website: https://superlativeformulas.com

page: https://www.facebook.com/profile.php?id=100075897440934

BIBLE DIRECTIONS TO HEAVEN: https://m.youtube.com/watch?v=m9Rmm7Mqt74

01/04/2023

FEATURED IN SUPERLATIVE FORMULA (available in 20:1 and 50:1 concentrations)

Antimutagenic effects of subfractions of Chaga mushroom (Inonotus obliquus) extract

Abstract:
“Inonotus obliquus is a mushroom commonly known as Chaga that is widely used in folk medicine in Siberia, North America, and North Europe. Here, we evaluated the antimutagenic and antioxidant capacities of subfractions of Inonotus obliquus extract. The ethyl acetate extract was separated by vacuum chromatography into three fractions, and the fraction bearing the highest antimutagenic activity was subsequently separated into four fractions by reversed phase (ODS-C18) column chromatography. The most antimutagenic fraction was then separated into two subfractions (subfractions 1 and 2) by normal phase silica gel column chromatography. Ames test analysis revealed that the subfractions were not mutagenic. At 50 μg/plate, subfractions 1 and 2 strongly inhibited the mutagenesis induced in Salmonella typhimurium strain TA100 by the directly acting mutagen MNNG (0.4 μg/plate) by 80.0% and 77.3%, respectively. They also inhibited 0.15 μg/plate 4NQO-induced mutagenesis in TA98 and TA100 by 52.6–62.0%. The mutagenesis in TA98 induced by the indirectly acting mutagens Trp-P-1 (0.15 μg/plate) and B(α)P (10 μg/plate) was reduced by 47.0–68.2% by the subfractions, while the mutagenesis in TA100 by Trp-P-1 and B(α)P was reduced by 70.5–87.2%. Subfraction 1 was more inhibitory than subfraction 2 with regard to the mutagenic effects of 4NQO, Trp-P-1, and B(α)P. Subfractions 1 and 2 also had a strong antioxidant activity against DPPH radicals and were identified by MS, 1H NMR and 13C NMR analyses as 3β-hydroxy-lanosta-8, 24-dien-21-al and inotodiol, respectively. Thus, we show that the 3β-hydroxy-lanosta-8, 24-dien-21-al and inotodiol components of Inonotus obliquus bear antimutagenic and antioxidative activities.” https://www.sciencedirect.com/science/article/abs/pii/S1383571808003008

SUPERLATIVE FORMULAS website: https://superlativeformulas.com

page: https://www.facebook.com/profile.php?id=100075897440934

BIBLE DIRECTIONS TO HEAVEN: https://m.youtube.com/watch?v=m9Rmm7Mqt74

01/04/2023

FEATURED IN SUPERLATIVE FORMULAS: ANTI-OBESITY (200:1 concentration)

Bitter melon (Momordica charantia L.) inhibits adipocyte hypertrophy and down regulates lipogenic gene expression in adipose tissue of diet-induced obese rats

Abstract:
“Bitter melon (Momordica charantia; BM) has been shown to ameliorate diet-induced obesity and insulin resistance. To examine the effect of BM supplementation on cell size and lipid metabolism in adipose tissues, three groups of rats were respectively fed a high-fat diet supplemented without (HF group) or with 5 % lyophilised BM powder (HFB group), or with 0·01 % thiazolidinedione (TZD) (HFT group). A group of rats fed a low-fat diet was also included as a normal control. Hyperinsulinaemia and glucose intolerance were observed in the HF group but not in HFT and HFB groups. Although the number of large adipocytes (>180 μm) of both the HFB and HFT groups was significantly lower than that of the HF group, the adipose tissue mass, TAG content and glycerol-3-phosphate dehydrogenase activity of the HFB group were significantly lower than those of the HFT group, implying that BM might reduce lipogenesis in adipose tissue. Experiment 2 was then conducted to examine the expression of lipogenic genes in adipose tissues of rats fed low-fat, HF or HFB diets. The HFB group showed significantly lower mRNA levels of fatty acid synthase, acetyl-CoA carboxylase-1, lipoprotein lipase and adipocyte fatty acid-binding protein than the HF group (P < 0·05). These results indicate BM can reduce insulin resistance as effective as the anti-diabetic drug TZD. Furthermore, BM can suppress the visceral fat accumulation and inhibit adipocyte hypertrophy, which may be associated with markedly down regulated expressions of lipogenic genes in the adipose.” https://scholar.google.com/scholar?hl=en&as_sdt=0%2C44&q=bitter+melon+obesity&oq=bitter+melon+obes =gs_qabs&t=1672830389715&u=%23p%3DnDYcIB58-xUJ

SUPERLATIVE FORMULAS website: https://superlativeformulas.com

page: https://www.facebook.com/profile.php?id=100075897440934

BIBLE DIRECTIONS TO HEAVEN: https://m.youtube.com/watch?v=m9Rmm7Mqt74

12/28/2022

MELASTOMA MALABATHRICUM FEATURED IN SUPERLATIVE FORMULAS: ANTI-OBESITY (200:1 concentration)

Anti-Obesity Effects of Melastoma malabathricum var Alba Linn in Rats Fed with a High-Fat Diet

Abstract:
“Obesity is one of the major public health problems worldwide and it is generally associated with many diseases. Although synthetic drugs are available for the treatment of obesity, herbal remedies may provide safe, natural, and cost-effective alternative to synthetic drugs. One example of such drugs is Melastoma malabathricum var Alba Linn (MM). Although several studies have been reported for the pharmacological activities of MM, there is no report on the anti-obesity effect of MM. The aim of the present study is to evaluate the anti-obesity potential of methanolic extract of MM. The anti-obesity effect of MM on rats fed with a high-fat diet was investigated through determination of the changes in body weight, fat weight, organ weights, and blood biochemicals. The animals in this study were divided into three groups: a normal group with a standard diet 👎, a control group fed with high-fat diet (C), and a MM treatment group fed with high-fat (HFD + MM) diet for 8 weeks. There was no significant difference in the amount of food intake between control and HFD + MM treatments. These results also suggest that MM does not induce a dislike for the diet due to its smell or taste. The study shows that MM significantly prevented increases in body weight, cholesterol, LDL, HDL, and total lipids that resulted from the high-fat diet. MM also decreased the epididymal fat (E-fat) and retroperitoneal fat (R-fat) weights and phospholipid concentrations induced by the high-fat diet. On the basis of these findings, it was concluded that MM had anti-obesity effects by suppressing body weight gain and abdominal fat formation.” https://link.springer.com/article/10.1208/s12249-014-0245-1

SUPERLATIVE FORMULAS website: https://superlativeformulas.com

page: https://www.facebook.com/profile.php?id=100075897440934

BIBLE DIRECTIONS TO HEAVEN: https://m.youtube.com/watch?v=m9Rmm7Mqt74

12/23/2022

Featured in SUPERLATIVE FORMULAS: ANALGESIC (200:1 concentration)

Anti-Arthritic Activity of Premna serratifolia Linn., Wood against Adjuvant Induced Arthritis

Abstract

“Adjuvant induced arthritis is a chronic crippling, skeleton-muscular disorder having nearest approximation to human rheumatoid arthritis for which there is currently no medicine available effecting a permanent cure. Even modern drugs used for the amelioration of the symptoms, offer only temporary relief and also produce severe side effects. In the indigenous system of medicine, wood of Premna serratifolia Linn., is reported to be useful in the treatment of arthritis. It is a large shrub, distributed throughout Asia, used against a wide variety of diseases. However, no systematic study has been reported regarding its anti-arthritic activity. This work was aimed at the scientific validation of the ethno-pharmacological claim about its anti-arthritic property. In the present study, anti-arthritic activity of ethanol extract of Premna serratifolia Linn., wood is done by Freund's adjuvant induced arthritis model. Loss in body weight during arthritis condition was corrected on treatment with ethanol extract and standard drug, indomethacin. Biochemical parameters such as hemoglobin content, total WBC, RBC, erythrocyte and sedimentation rate were also estimated. The ethanol extract at the dose of 300 mg/kg body weight inhibited the rat paw edema by 68.32% which is comparable with standard drug indomethacin 74.87% inhibition of rat paw edema after 21 days. The results of the current investigation concluded, ethanol extract of Premna serratifolia Linn., wood possess a significant anti-arthritic activity against adjuvant induced arthritis and justifying its therapeutic role in arthritic condition. The observed anti-arthritic activity may be due to the presence of phytoconstituents such as irridiod glycosides, alkaloids, phenolic compounds and flavonoids.” https://pubmed.ncbi.nlm.nih.gov/23407688/

SUPERLATIVE FORMULAS website: https://superlativeformulas.com

page: https://www.facebook.com/profile.php?id=100075897440934

BIBLE DIRECTIONS TO HEAVEN: https://m.youtube.com/watch?v=m9Rmm7Mqt74

12/16/2022

EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY POTENTIAL OF MIMOSA PUDICA LINN (featured in SUPERLATIVE FORMULAS: ANALGESIC 200:1)

Abstract:
“The aim of this work to evaluate the acute toxicity, Analgesic and Anti-Inflammatory activity of Ethanolic extract of Mimosa Pudica Linn. In the acute toxicity study, the extracts were administered in doses of 5, 50, 300 and 2000 mg/kg po and behavioral changes were observed after 24 hrs. In hot plate test the pethidine treated group, Tail flick Diclofenace treated group, and group given ethanolic extracts as 250 mg/kg and 500 mg/kg showed increase in latency time dose dependent manner. Oral administration of ethanolic extract at a dose of 500 mg/kg showed significantly reduction of writhing response induced by acetic acid as compared the dose given at 250 mg/kg.”https://www.researchgate.net/profile/Deepak-Jain-13/publication/267262127_EVALUATION_OF_ANALGESIC_AND_ANTI-INFLAMMATORY_POTENTIAL_OF_MIMOSA_PUDICA_LINN/links/54757a230cf245eb4370c7b3/EVALUATION-OF-ANALGESIC-AND-ANTI-INFLAMMATORY-POTENTIAL-OF-MIMOSA-PUDICA-LINN.pdf

SUPERLATIVE FORMULAS website: https://superlativeformulas.com

page: https://www.facebook.com/profile.php?id=100075897440934

BIBLE DIRECTIONS TO HEAVEN: https://m.youtube.com/watch?v=m9Rmm7Mqt74

12/15/2022

STAR ANISE EXTRACT CAPABLE OF PROTECTING DNA FROM RADIATION INDUCED DAMAGE.

Antioxidant and radio-protective activities of lemon grass and star anise extracts (featured in original SUPERLATIVE FORMULA 20:1 and 50:1)

Abstract:
“Aqueous extracts of Lemon grass (Cymbopogon citratus) and Star-anise (Illicium verum) were prepared and evaluated for antioxidant activity using various in vitro assay systems. The extracts, even at low concentrations, worked as efficient scavengers of DPPH (IC50 of 72–90 µg/ml), and superoxide radicals (77–87% scavenging). The antioxidant activity coefficient as determined by β-carotene bleaching assay was high (600–800). Both the extracts exhibited high reducing power indicating good antioxidant potential. Lipid peroxidation, monitored as thiobarbituric acid-reactive substance (TBARS) were significantly lower (p

12/14/2022

PINE NEEDLE EXTRACT CAPABLE OF BLOCKING, REDUCING, AND/OR PREVENTING MUTATIONS.

Study on the antimutagenic effect of pine needle extract (featured in the original SUPERLATIVE FORMULA 20:1 and 50:1)

Abstract:

“The micronulceus test and sister-chromatic exchange (SCE) test were used to research the antimutagenic effect of pine needle extract. The results showed that the mutagenic effect of cyclosphamide (CP) was inhibited by the pine needle extract. The micronucleus frequencies (MNF) of mouse bone marrow and human lymphocytes from peripheral blood were decreased with the effect of the extract (the dose was 2000 mg/kg or 5 mg/ml); the frequency of SCE in human lymphocytes was also reduced significantly, which indicated that the MNF and the SCE frequencies were negatively correlated with the dose of pine needle extract (r = −0.9782, −0.9587, −.09765, respectively). This suggested that the pine needle extract was an effective antimutagen and it is important to choose the proper doses of pine needle extract for antitumor effect.” https://www.sciencedirect.com/science/article/abs/pii/0165799295000267

SUPERLATIVE FORMULAS website: https://superlativeformulas.com

page: https://www.facebook.com/profile.php?id=100075897440934

BIBLE DIRECTIONS TO HEAVEN: https://m.youtube.com/watch?v=m9Rmm7Mqt74

12/13/2022

SUPERLATIVE FORMULAS: PROSEED (200:1 concentration)

One of the most discarded parts of plants happens to contain some of the most beneficial compounds for a persons health. This formula combines 111 seed extracts together into one concentrated formula to make it easy for anyone to reap the benefits of these medicinal compounds.

Celery Seed Extract
Grape Seed Extract
Fenugreek Seed Extract
Coix Seed Extract
Jujube Seed Extract
Safflower Seed Extract
Raspberry Seed Extract
Pine Seed Extract
Perilla Seed Extract
Cassia Seed Extract
Fennel Seed Extract
Nettle Seed Extract
Papaya Seed Extract
Cucumber Seed Extract
Milk Thistle Seed Extract
Pomegranate Seed Extract
Moringa Seed Extract
Grapefruit Seed Extract
Griffonia Seed Extract
Apricot Seed Extract
Cnidium Seed Extract
Celastrus Seed Extract
Dodder Seed Extract
Feather Cockscomb Seed Extract
Black Seed Extract
Jackfruit Seed Extract
Caraway Seed Extract
Horse Chestnut Seed Extract
Ajwain Seed Extract
Anise Seed Extract
Coriander Seed Extract
Cumin Seed Extract
Dill Seed Extract
Black Mustard Seed Extract
White Mustard Seed Extract
Flax Seed Extract
Chia Seed Extract
Psyllium Seed Extract
Pumpkin Seed Extract
Green Coffee Bean Extract
Cocoa (Seed Extract)
Sesame Seed Extract
White Kidney Bean Extract
Black Bean Extract
Black Pepper Extract
Oat (Seed) Extract
Mucuna Seed Extract
Black Rice Extract
Buckwheat (Seed) Extract
Apple Seed Extract
Orange Seed Extract
Lemon Seed Extract
African Mango Seed Extract
Avocado Seed Extract
Parsley Seed Extract
Garden Cress Seed Extract
Cantaloupe Seed Extract
Watermelon Seed Extract
Fig Seed Extract
Cherry Seed Extract
Cranberry Seed Extract
Guava Seed Extract
Kiwi Seed Extract
Kumquat Seed Extract
Longan Seed Extract
Lychee Seed Extract
Melon Seed Extract
Rosehip Seed Extract
Olive Seed Extract
Passionfruit Seed Extract
Pear Seed Extract
Pineapple Seed Extract
Plum Seed Extract
Starfruit Seed Extract
Tangerine Seed Extract
Strawberry Seed Extract
Blueberry Seed Extract
Blackberry Seed Extract
Mulberry Seed Extract
Juniper Berry Seed Extract
Golden Berry Seed Extract
Goji Berry Seed Extract
Nutmeg (Seed) Extract
Sunflower Seed Extract
Cardamom Seed Extract
Squash Seed Extract
Radish Seed Extract
Zucchini Seed Extract
Egusi Seed Extract
Lotus Seed Extract
Amaranth (Seed) Extract
Beet Seed Extract
Artichoke Seed Extract
Bell Pepper Seed Extract
Broccoli Seed Extract
Burdock Seed Extract
Sea Buckthorn Seed Extract
Evening primrose seed extract
Semen Pruni Seed Extract
Plantain Seed Extract
Benincasa hispida Seed Extract
Angelica Seed Extract
Leek Seed Extract
Sterculia Seed Extract
Chili Seed Extract
Allium tuberosum Seed Extract
Carrot Seed Extract
Cowherb Seed Extract
Aframomum Melegueta Seed Extract
Kola Nut Extract
Trichosanthes kirilowii Maxim Seed Extract

SUPERLATIVE FORMULAS website: https://superlativeformulas.com

page: https://www.facebook.com/profile.php?id=100075897440934

BIBLE DIRECTIONS TO HEAVEN: https://m.youtube.com/watch?v=m9Rmm7Mqt74

12/13/2022

Nootropic activity of Celastrus paniculatus seed (featured in SUPERLATIVE FORMULA 20:1 and 50:1)

Abstract: “The effect of Celastrus paniculatus Willd. (Celastraceae) seed aqueous extract on learning and memory was studied using elevated plus maze and passive avoidance test (sodium nitrite induced amnesia rodent model). The aqueous seed extract was administered orally in two different doses to rats (350 and 1050 mg/kg) and to mice (500 and 1500 mg/kg). The results were compared to piracetam (100 mg/kg, p.o.) used as a standard drug. Chemical hypoxia was induced by subcutaneous administration of sodium nitrite (35 mg/kg), immediately after acquisition training. In elevated plus maze and sodium nitrite-induced amnesia model, Celastrus paniculatus extract has showed statistically significant improvement in memory process when compared to control. The estimation of acetylcholinesterase enzyme in rat brain supports the plus maze and passive avoidance test by reducing acetylcholinesterase activity which helps in memory performance. The study reveals that the aqueous extract of Celastrus paniculatus seed has dose-dependent cholinergic activity, thereby improving memory performance. The mechanism by which Celastrus paniculatus enhances cognition may be due to increased acetylcholine level in rat brain.” https://www.tandfonline.com/doi/full/10.3109/13880200903127391

SUPERLATIVE FORMULAS website: https://superlativeformulas.com

page: https://www.facebook.com/profile.php?id=100075897440934

BIBLE DIRECTIONS TO HEAVEN: https://m.youtube.com/watch?v=m9Rmm7Mqt74

12/08/2022

ANALGESIC AND PSYCHOPHARMACOLOGICAL EFFECTS OF THE GUM RESIN OF BOSWELLIA SERRATA (featured in SUPERLATIVE FORMULAS: ANALGESIC).

“Abstract
The non–phenolic fraction obtained from the gurn resin of Boswellia serrata Roxb. was found to exhibit marked sedative and analgesic effects. The drug produced a reduction in the spontaneous motor activity and caused ptosis in rats. A significant analgesic effect was observed as evaluated by both the hot–wire and the mechanical pressure methods. These effect started within 30 minutes and lasted for about 2 hours. Nalorphine caused only an insignificant antagonism to the analgesic effect of the drug. The fraction potentiated the secobarbitone–induced hypnosis in rats. The secondary–conditioned response (SCR) was specifically blocked in the trained rats, whereas the conditioned–avoidance response (CAR) was not significantly affected.” https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0028-1099651?device=mobile&innerWidth=980&offsetWidth=980

SUPERLATIVE FORMULAS website: https://superlativeformulas.com

page: https://www.facebook.com/profile.php?id=100075897440934

BIBLE DIRECTIONS TO HEAVEN: https://m.youtube.com/watch?v=m9Rmm7Mqt74

11/30/2022

SUPERLATIVE FORMULAS: ANALGESIC
testimony:

“Since taking the herbal blend daily for the past few months, the symptoms that I experience with my autoimmune condition have been greatly reduced. I sleep now and my cravings are gone. The skin rash that has plagued me for years has been reduced by 70%. I have greater mental clarity and my mood has improved. I am no longer having daily headaches. And I've lost 9 pounds and changed nothing further about my diet except adding the herbal blend to my morning coffee and my evening tea, taken about ten hours apart. I believe the blend that I am taking is improving my symptoms and healing my gut and immune system. I took baseline blood tests before I began taking the herbs and I take a new test mid-December so I am excited to share the measurable improvements to my immune system when that time comes. I am so grateful for the opportunity to heal naturally with God's medicine!”

- CHRISTY

SUPERLATIVE FORMULAS website: https://superlativeformulas.com

page: https://www.facebook.com/profile.php?id=100075897440934

BIBLE DIRECTIONS TO HEAVEN: https://m.youtube.com/watch?v=m9Rmm7Mqt74

Manifest Ministry page: https://business.facebook.com/latest/home?asset_id=110085284011381&nav_ref=pages_classic_isolated_section_inbox_redirect

11/29/2022

Thymoquinone (featured in SUPERLATIVE FORMULAS: ANTI-OBESITY) ameliorates diabetic phenotype in Diet-Induced Obesity mice via activation of SIRT-1-dependent pathways.

“Abstract:
Thymoquinone, a natural occurring quinone and the main bioactive component of plant Nigella sativa, undergoes intracellular redox cycling and re-oxidizes NADH to NAD+. TQ administration (20 mg/kg/bw/day) to the Diet-Induced Obesity (DIO) mice reduced their diabetic phenotype by decreasing fasting blood glucose and fasting insulin levels, and improved glucose tolerance and insulin sensitivity as evaluated by oral glucose and insulin tolerance tests (OGTT and ITT). Furthermore, TQ decreased serum cholesterol levels and liver triglycerides, increased protein expression of phosphorylated Akt, decreased serum levels of inflammatory markers resistin and MCP-1, and decreased NADH/NAD+ ratio. These changes were paralleled by an increase in phosphorylated SIRT-1 and AMPKα in liver and phosphorylated SIRT-1 in skeletal muscle. TQ also increased insulin sensitivity in insulin-resistant HepG2 cells via a SIRT-1-dependent mechanism. These findings are consistent with the TQ-dependent re-oxidation of NADH to NAD+, which stimulates glucose and fatty acid oxidation and activation of SIRT-1-dependent pathways. Taken together, these results demonstrate that TQ ameliorates the diabetic phenotype in the DIO mouse model of type 2 diabetes.” https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0185374

SUPERLATIVE FORMULAS website: https://superlativeformulas.com

page: https://www.facebook.com/profile.php?id=100075897440934

BIBLE DIRECTIONS TO HEAVEN: https://m.youtube.com/watch?v=m9Rmm7Mqt74

11/26/2022

Novel weight-reducing activity of Galega officinalis (featured in SUPERLATIVE FORMULAS: ANTI-OBESITY) in mice

“Abstract:
Galega officinalis (galega, Goat's Rue, French Lilac) is well known for its hypoglycaemic action and has been used as part of a plant mixture in the treatment of diabetes mellitus. During pharmacological investigations of an ethanolic extract of a powdered mixture of equal proportions of G. officinalis, Cressa cretica, Mangifera indica and Syzygium jambolanum, a weight reducing effect of galega was discovered. In this study we have investigated the novel weight reducing effect of galega in mice. Galega herb (10% w/w in the diet) caused a significant reduction in body weight in both normal and genetically obese (ob/ob) animals treated for 28 days when compared with respective controls (P < 0.01). In normal mice, the weight loss was reversible and initially associated with a transient reduction in food intake but was then maintained even in the presence of increased eating above the control level. Pair-fed normal mice receiving galega for seven days also showed significant weight loss (P < 0.01, compared with the control) in the presence of increasing food intake. In sharp contrast, weight loss in galega-treated ob/ob mice was accompanied by a persistent reduction in food intake over the 28-day treatment period. Post-mortem examinations of all galega-treated mice revealed a striking absence of body fat. Serum glucose was significantly reduced in both strains of mice receiving galega for 28 days (P < 0.01), whereas serum insulin was significantly reduced only in obese mice (P < 0.01). In summary, together with its established hypoglycaemic effects, galega has a novel weight reducing action that, in normal mice, is largely independent of a reduction in food intake. The mechanism of the weight reducing action of galega is unclear but involves loss of body fat.” https://pubmed.ncbi.nlm.nih.gov/10632090/ #:~:text=Galega%20herb%20%2810%25%20w%2Fw%20in%20the%20diet%29%20caused,when%20compared%20with%20respective%20controls%20%28P%20%3C%200.01%29.

SUPERLATIVE FORMULAS website: https://superlativeformulas.com

page: https://www.facebook.com/profile.php?id=100075897440934

BIBLE DIRECTIONS TO HEAVEN: https://m.youtube.com/watch?v=m9Rmm7Mqt74

11/23/2022

Antinociceptive effects of incarvillateine, a monoterpene alkaloid from Incarvillea sinensis (featured in SUPERLATIVE FORMULAS: ANALGESIC), and possible involvement of the adenosine system

Abstract:
“Incarvillea sinensis is a Bignoniaceae plant used to treat rheumatism and relieve pain in traditional Chinese medicine. As a major component of I. sinensis, incarvillateine has shown analgesic activity in mice formalin tests. Using a series of animal models, this study further evaluated the effects of incarvillateine against acute, inflammatory, and neuropathic pain. Incarvillateine (10 or 20 mg/kg, i.p.) dose-dependently attenuated acetic acid-induced writhing, but did not affect thermal threshold in the hot plate test. In a Complete Freund’s Adjuvant model, incarvillateine inhibited both thermal hyperalgesia and paw edema, and increased interleukin-1β levels. Additionally, incarvillateine attenuated mechanical allodynia induced by spared nerve injury or paclitaxel, whereas normal mechanical sensation was not affected. Incarvillateine did not affect locomotor activity and time on the rotarod at analgesic doses, and no tolerance was observed after 7 consecutive daily doses. Moreover, incarvillateine-induced antinociception was attenuated by theophylline, 1,3-dipropyl-8-cyclopentylxanthine, and 3,7-dimethyl-1-propargylxanthine, but not naloxone, indicating that the effects of incarvillateine on chronic pain were related to the adenosine system, but not opioid system. These results indicate that incarvillateine is a novel analgesic compound that is effective against inflammatory and neuropathic pain, and that its effects are associated with activation of the adenosine system.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630779/ #:~:text=Incarvillea%20sinensis%20is%20a%20Bignoniaceae%20plant%20used%20to,has%20shown%20analgesic%20activity%20in%20mice%20formalin%20tests.

SUPERLATIVE FORMULAS website: https://superlativeformulas.com

page: https://www.facebook.com/profile.php?id=100075897440934

BIBLE DIRECTIONS TO HEAVEN: https://m.youtube.com/watch?v=m9Rmm7Mqt74