Superlative Formulas

Superlative Formulas Providing formulas to promote longevity. Located in New Braunfels, Texas.

AMAZING properties of Urolithin B. Featured in SUPERLATIVE FORMULAS: ANTI-OBESITYhttps://superlativeformulas.com/product...
02/27/2024

AMAZING properties of Urolithin B. Featured in SUPERLATIVE FORMULAS: ANTI-OBESITY
https://superlativeformulas.com/products/anti-obesity

UROLITHIN B MAY PROMOTE MUSCLE GROWTH WHILE SIMULATANEOUSLY PROMOTING FAT LOSS!!! 👇👇👇

Urolithin B, a newly identified regulator of skeletal muscle mass:

"Our experiments reveal that urolithin B enhances the growth and differentiation of C2C12 myotubes by increasing protein synthesis and repressing the ubiquitin–proteasome pathway. Genetic and pharmacological arguments support an implication of the androgen receptor. Signalling analyses suggest a crosstalk between the androgen receptor and the mTORC1 pathway, possibly via AMPK. In vivo experiments confirm that urolithin B induces muscle hypertrophy in mice and reduces muscle atrophy after the sciatic nerve section." https://onlinelibrary.wiley.com/doi/full/10.1002/jcsm.12190

Urolithins Attenuate Multiple Symptoms of Obesity in Rats Fed on a High-Fat Diet:

"Indeed, a high-fat diet resulted in increased body weight, visceral adipose tissue mass, and oxidative stress in rats. However, treatment with both Uro-A and Uro-B decreased body weight and visceral adipose tissue mass. These metabolites restored hepatic antioxidant capacity and decreased lipid accumulation in addition to an increase in f***l fat excretion. Moreover, both Uro-A and Uro-B treatment downregulated the expression of LXRα and SREBP1c; involved in de novo lipogenesis while upregulating PPARα expression for increased fatty acid oxidation. Furthermore, Uro-A and Uro-B decreased the expression of PERK and IRE1α; which are involved in hepatic ER stress. Taken together, our results showed the potentials of Uro-A and Uro-B in mitigating obesity symptoms and they could thus provide promising roles in the future as functional anti-obesity"
candidates.https://www.tandfonline.com/doi/full/10.2147/DMSO.S268146

BIBLE DIRECTIONS TO HEAVEN: https://www.youtube.com/watch?v=m9Rmm7Mqt74

Featured in SUPERLATIVE FORMULAS: ANTI-OBESITY (200:1 concentration)Anti-Obesity Activity of the Marine Carotenoid Fucox...
02/05/2024

Featured in SUPERLATIVE FORMULAS: ANTI-OBESITY (200:1 concentration)

Anti-Obesity Activity of the Marine Carotenoid Fucoxanthin

ABSTRACT:
"Nowadays the global tendency towards physical activity reduction and an augmented dietary intake of fats, sugars and calories is leading to a growing propagation of overweight, obesity and lifestyle-related diseases, such diabetes, hypertension, dyslipidemia and metabolic syndrome. In particular, obesity, characterized as a state of low-level inflammation, is a powerful determinant both in the development of insulin resistance and in the progression to type 2 diabetes. A few molecular targets offer hope for anti-obesity therapeutics. One of the keys to success could be the induction of uncoupling protein 1 (UCP1) in abdominal white adipose tissue (WAT) and the regulation of cytokine secretions from both abdominal adipose cells and macrophage cells infiltrated into adipose tissue. Anti-obesity effects of fucoxanthin, a characteristic carotenoid, exactly belonging to xanthophylls, have been reported. Nutrigenomic studies reveal that fucoxanthin induces UCP1 in abdominal WAT mitochondria, leading to the oxidation of fatty acids and heat production in WAT. Fucoxanthin improves insulin resistance and decreases blood glucose levels through the regulation of cytokine secretions from WAT. The key structure of anti-obesity effect is suggested to be the carotenoid end of the polyene chromophore, which contains an allenic bond and two hydroxyl groups. Fucoxanthin, which can be isolated from edible brown seaweeds, recently displayed its many physiological functions and biological properties. We reviewed recent studies and this article aims to explain essential background of fucoxanthin, focusing on its promising potential anti-obesity effects. In this respect, fucoxanthin can be developed into promising marine drugs and nutritional products, in order to become a helpful functional food."https://www.mdpi.com/1660-3397/13/4/2196

Purchase here: https://superlativeformulas.com/products/anti-obesity

Home page: https://superlativeformulas.com/

Featured in SUPERLATIVE FORMULAS: ANTI-OBESITY (200:1 concentration) https://superlativeformulas.com/products/anti-obesi...
01/30/2024

Featured in SUPERLATIVE FORMULAS: ANTI-OBESITY (200:1 concentration) https://superlativeformulas.com/products/anti-obesity

Chebulinic acid blocks fat accumulation. 👇

Chebulinic Acid Suppresses Adipogenesis in 3T3-L1 Preadipocytes by Inhibiting PPP1CB Activity

ABSTRACT:
"Depletion of protein phosphatase-1 catalytic subunit beta (PPP1CB), a serine/threonine protein phosphatase and potent adipogenic activator, suppresses the differentiation of 3T3-L1 preadipocytes into mature adipocytes. Therefore, PPP1CB is considered as a potential therapeutic target for obesity. We screened 1033 natural products for PPP1CB inhibitors and identified chebulinic acid, which is abundantly present in the seeds of Euphoria longana and fruits of Terminalia chebula. Chebulinic acid strongly inhibited the hydrolysis of 6,8-difluoro-4-methylumbelliferyl phosphate by PPP1CB (IC50 = 300 nM) and demonstrated potent antiadipogenic effects in 3T3-L1 preadipocytes in a concentration-dependent manner. Additional studies have demonstrated that chebulinic acid suppresses early differentiation by downregulating key transcription factors that control adipogenesis in 3T3-L1 cells. These results suggested that chebulinic acid may be a potential therapeutic agent for treating obesity by inhibiting PPP1CB activity."https://www.mdpi.com/1422-0067/23/2/865

Order formula here: https://superlativeformulas.com/products/anti-obesity

Featured in SUPERLATIVE FORMULAS: ANTI-OBESITY (200:1 concentration)"Urolithin A exerts antiobesity effects through enha...
01/16/2024

Featured in SUPERLATIVE FORMULAS: ANTI-OBESITY (200:1 concentration)

"Urolithin A exerts antiobesity effects through enhancing adipose tissue thermogenesis in mice"

Purchase here: https://superlativeformulas.com/products/anti-obesity

"Obesity leads to multiple health problems, including diabetes, fatty liver, and even cancer. Here, we report that urolithin A (UA), a gut-microflora–derived metabolite of pomegranate ellagitannins (ETs), prevents diet-induced obesity and metabolic dysfunctions in mice without causing adverse effects. UA treatment increases energy expenditure (EE) by enhancing thermogenesis in brown adipose tissue (BAT) and inducing browning of white adipose tissue (WAT). Mechanistically, UA-mediated increased thermogenesis is caused by an elevation of triiodothyronine (T3) levels in BAT and inguinal fat depots. This is also confirmed in UA-treated white and brown adipocytes. Consistent with this mechanism, UA loses its beneficial effects on activation of BAT, browning of white fat, body weight control, and glucose homeostasis when thyroid hormone (TH) production is blocked by its inhibitor, propylthiouracil (PTU). Conversely, administration of exogenous tetraiodothyronine (T4) to PTU-treated mice restores UA-induced activation of BAT and browning of white fat and its preventive role on high-fat diet (HFD)-induced weight gain. Together, these results suggest that UA is a potent antiobesity agent with potential for human clinical applications."https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000688

GLP-1 agonist puerarin featured in SUPERLATIVE FORMULAS: ANTI-OBESITY (200:1 concentration) Purchase here: https://super...
01/16/2024

GLP-1 agonist puerarin featured in SUPERLATIVE FORMULAS: ANTI-OBESITY (200:1 concentration)

Purchase here: https://superlativeformulas.com/products/anti-obesity

"Puerarin Protects Pancreatic β-Cells in Obese Diabetic Mice via Activation of GLP-1R Signaling"

"Diabetes is characterized by a loss and dysfunction of the β-cell. Glucagon-like peptide 1 receptor (GLP-1R) signaling plays an important role in β-cell survival and function. It is meaningful to identify promising agents from natural products which might activate GLP-1R signaling. In this study, puerarin, a diet isoflavone, was evaluated its beneficial effects on β-cell survival and GLP-1R pathway. We showed that puerarin reduced the body weight gain, normalized blood glucose, and improved glucose tolerance in high-fat diet-induced and db/db diabetic mice. Most importantly, increased β-cell mass and β-cell proliferation but decreased β-cell apoptosis were observed in puerarin-treated diabetic mice as examined by immunostaining of mice pancreatic sections. The protective effect of puerarin on β-cell survival was confirmed in isolated mouse islets treated with high glucose. Further mechanism studies showed that the circulating level of GLP-1 in mice was unaffected by puerarin. However, puerarin enhanced GLP-1R signaling by up-regulating expressions of GLP-1R and pancreatic and duodenal homeobox 1, which subsequently led to protein kinase B (Akt) activation but forkhead box O1 inactivation, and promoted β-cell survival. The protective effect of puerarin was remarkably suppressed by Exendin(9–39), an antagonist of GLP-1R. Our study demonstrated puerarin improved glucose homeostasis in obese diabetic mice and identified a novel role of puerarin in protecting β-cell survival by mechanisms involving activation of GLP-1R signaling and downstream targets."https://academic.oup.com/mend/article/30/3/361/2556481?login=false

https://superlativeformulas.com/

"Shilajit extract reduces oxidative stress, inflammation, and bone loss to dose-dependently preserve bone mineral densit...
01/16/2024

"Shilajit extract reduces oxidative stress, inflammation, and bone loss to dose-dependently preserve bone mineral density in postmenopausal women with osteopenia: A randomized, double-blind, placebo-controlled trial"

"Daily supplementation with this shilajit extract supports BMD in postmenopausal women with osteopenia in part by attenuating the increased bone turnover, inflammation and oxidative stress that coincides with estrogen deficiency in this population at increased risk for osteoporosis and bone fractures." https://www.sciencedirect.com/science/article/abs/pii/S0944711322004135

SUPERLATIVE FORMULAS: SHILAJIT (standardized at 50% fulvic acid).

Shilajit is a fulvic acid rich resinous substance that is harvested in the Himalayan mountains, offering a plethora of possible beneficial effects on the body:
1.) Enhancing cognition
2.) Immunomodulator
3.) Anti-ulcerogenic
4.) Adaptogenic/Anti stress
5.) Lowering blood sugar
6.) Antioxidant
7.) Electrolytes/minerals
8.) Increasing bioavailability of other substances.
9.) Analgesic
10.) Reproductive system
11.) Etc..
Studies highlighting the incredible health benefits that Shilajit may provide- https://superlativeformulas.com/pages/SHILAJIT

SUPERLATIVE FORMUALS: SHILAJIT extract is standardized at a highly potent 50% fulvic acid content!
Around 300 (1/8th tsp) servings in 100g bag! $75.

Purchase here: https://superlativeformulas.com/products/shilajit

Featured in SUPERLATIVE FORMULAS: ANTI-OBESITY (200:1 concentration)“Nuciferine (NF) is a high-quality aporphine alkaloi...
01/12/2024

Featured in SUPERLATIVE FORMULAS: ANTI-OBESITY (200:1 concentration)

“Nuciferine (NF) is a high-quality aporphine alkaloid present in lotus leaf. Unlike the chemical drugs, NF elicits anti-obesity, anti-dyslipidemia, anti-hyperglycemic, anti-hypouricemic, anti-inflammatory, and anti-tumor effects, and affinity to neural receptors, and protection against obesity-related diseases. “ https://www.sciencedirect.com/science/article/abs/pii/S1043661821005867

For more info, studies, ingredients pertaining to this formula- https://superlativeformulas.com/products/anti-obesity

SUPERLATIVE FORMULAS: ANTI-OBESITY (200:1 Concentration)This formula is designed to promote:1.) Fat burning (thermogenes...
12/22/2023

SUPERLATIVE FORMULAS: ANTI-OBESITY (200:1 Concentration)

This formula is designed to promote:
1.) Fat burning (thermogenesis)
2.) Fat accumulation (Anti-Adipogenic)
3.) Glucose blocking
4.) GLP-1 activation

I only have samples available now which have around 82 1/8th tsp servings. So it should last you awhile depending on your dosage. You can order here: https://superlativeformulas.com/products/anti-obesity. I recommend to start with 1/8th tsp because this formula is VERY potent. DO NOT take this blend and try and force-feed yourself because it will make you nauseous. I recommend taking it in black coffee. For best results, eating low insulin foods will speed up fat loss immensely. Leafy greens, avocados, certain nuts, etc. You may or may not notice its effects when you first take it. Allow it to build up in your system. Caution: formula has a mild spicy kick to it. Will be addressed in next batch.

ANTI-OBESITY formula: https://superlativeformulas.com/products/anti-obesity

Featured in SUPERLATIVE FORMULAS: ANTI-OBESITY (200:1 concentration)Anemarrhena asphodeloides stimulates GLP-1 secretion...
12/22/2023

Featured in SUPERLATIVE FORMULAS: ANTI-OBESITY (200:1 concentration)

Anemarrhena asphodeloides stimulates GLP-1 secretion which is the same mechansm of action that produces the weightloss effects of Ozempic, Wegovy, etc. 👇

Aqueous extracts of Anemarrhena asphodeloides stimulate glucagon-like pepetide-1 secretion in enteroendocrine NCI-H716 cells

Anemarrhena asphodeloides (AA), a bitter taste herbal medicine, has been prescribed in traditional oriental medicine to treat diabetes mellitus. Here, AA was extracted and fractionated to investigate its effects on the stimulation of glucagon-like peptide-1 (GLP-1) secretion in enteroendocrine cells. GLP-1 is secreted from the human enteroendocrine L cells to the blood in response to ingested nutrients. Because GLP-1 increases glucose dependent insulin release, it is known as a therapeutic method for the treatment of type II diabetes mellitus. The human enteroendocrine L cell line NCI-H716 expresses various chemoreceptors including the G protein coupled receptor (GPCR). Previous studies suggested that, through the GPCR signaling pathway, the secretion of GLP-1 can be induced in NCI-H716. Accordingly, we studied the GLP-1 stimulation effect of the AA extract and its mode-of-action using the GLP-1 ELISA and microarray. Functional categorization of the microarray data confirmed up or down-regulated gene expressions associated with the GPCR signaling pathway. This study demonstrates that AA extracts have a scientific possibility as a GLP-1 stimulant and thus may have the potential to be a therapeutic herbal medicine for type II diabetes mellitus.https://link.springer.com/article/10.1007/s13206-013-7213-9

This formula is designed to promote:
1.) Fat burning (thermogenesis)
2.) Fat accumulation (Anti-Adipogenic)
3.) Glucose blocking
4.) GLP-1 activation

I only have samples available now of this prototype which has around 82 1/8th tsp servings. So it should last you awhile depending on your dosage. You can order here: https://superlativeformulas.com/products/anti-obesity. I recommend to start with 1/8th tsp because this formula is VERY potent. DO NOT take this blend and try and force-feed yourself because it will make you nauseous. I recommend taking it in black coffee. For best results, eating low insulin foods will speed up fat loss immensely. Leafy greens, avocados, certain nuts, etc. You may or may not notice its effects when you first take it. Allow it to build
up in your system. Caution: formula has a mild spicy kick to it. Will be addressed in next batch.

ANTI-OBESITY formula: https://superlativeformulas.com/products/anti-obesity

BIBLE DIRECTIONS TO HEAVEN: https://www.youtube.com/watch?v=m9Rmm7Mqt74...

Featured in SUPERLATIVE FORMULAS: ANTI-OBESITY (200:1 concentration)"Here, we show that the prenylated chalcone, xanthoh...
12/14/2023

Featured in SUPERLATIVE FORMULAS: ANTI-OBESITY (200:1 concentration)

"Here, we show that the prenylated chalcone, xanthohumol (XN), induces beiging of white adipocytes, stimulates lipolysis, and inhibits adipogenesis of murine 3T3-L1 adipocytes and primary human subcutaneous preadipocytes and these effects are partly mediated by the activation of the AMP-activated protein kinase (AMPK) signaling pathway." https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-018-0277-8

This formula is designed to promote:

1.) Fat burning (thermogenesis)
2.) Fat accumulation (Anti-Adipogenic)
3.) Glucose blocking
4.) GLP-1 activation

I only have samples available now of this prototype which has around 82 1/8th tsp servings. So it should last you awhile depending on your dosage. You can order here: https://superlativeformulas.com/products/anti-obesity. I recommend to start with 1/8th tsp because this formula is VERY potent. DO NOT take this blend and try and force-feed yourself because it will make you nauseous. I recommend taking it in black coffee. For best results, eating low insulin foods will speed up fat loss immensely. Leafy greens, avocados, certain nuts, etc. You may or may not notice its effects when you first take it. Allow it to build
up in your system.

ANTI-OBESITY formula: https://superlativeformulas.com/products/anti-obesity

BIBLE DIRECTIONS TO HEAVEN: https://www.youtube.com/watch?v=m9Rmm7Mqt74...

Featured in SUPERLATVE FORMULAS: ANTI-OBESITY"This data supports a model in which ursolic acid reduces obesity, glucose ...
12/14/2023

Featured in SUPERLATVE FORMULAS: ANTI-OBESITY

"This data supports a model in which ursolic acid reduces obesity, glucose intolerance and fatty liver disease by increasing skeletal muscle and brown fat, and suggest ursolic acid as a potential therapeutic approach for obesity and obesity-related illness." https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0039332

This formula is designed to promote:

1.) Fat burning (thermogenesis)
2.) Fat accumulation (Anti-Adipogenic)
3.) Glucose blocking
4.) GLP-1 activation

I only have samples available now which have around 82 1/8th tsp servings. So it should last you awhile depending on your dosage. You can order here: https://superlativeformulas.com/products/anti-obesity. I recommend to start with 1/8th tsp because this formula is VERY potent. DO NOT take this blend and try and force-feed yourself because it will make you nauseous. I recommend taking it in black coffee. For best results, eating low insulin foods will speed up fat loss immensely. Leafy greens, avocados, certain nuts, etc. You may or may not notice its effects when you first take it. Allow it to build up in your system.

ANTI-OBESITY formula: https://superlativeformulas.com/products/anti-obesity

BIBLE DIRECTIONS TO HEAVEN: https://www.youtube.com/watch?v=m9Rmm7Mqt74&embeds_referring_euri=https%3A%2F%2Fsuperlativeformulas.com%2F&source_ve_path=Mjg2NjY&feature=emb_logo

SUPERLATIVE FORMULAS: ANTI-OBESITY (200:1 Concentration)This formula is designed to promote:1.) Fat burning (thermogenes...
12/05/2023

SUPERLATIVE FORMULAS: ANTI-OBESITY (200:1 Concentration)

This formula is designed to promote:
1.) Fat burning (thermogenesis)
2.) Fat accumulation (Anti-Adipogenic)
3.) Glucose blocking
4.) GLP-1 activation

I only have samples available now which have around 82 1/8th tsp servings. So it should last you awhile depending on your dosage. You can order here: https://superlativeformulas.com/products/anti-obesity. I recommend to start with 1/8th tsp because this formula is VERY potent. DO NOT take this blend and try and force-feed yourself because it will make you nauseous. I recommend taking it in black coffee. For best results, eating low insulin foods will speed up fat loss immensely. Leafy greens, avocados, certain nuts, etc. You may or may not notice its effects when you first take it. Allow it to build up in your system. Caution: formula has a mild spicy kick to it. Will be addressed in next batch.

ANTI-OBESITY formula: https://superlativeformulas.com/products/anti-obesity

BIBLE DIRECTIONS TO HEAVEN: https://www.youtube.com/watch?v=m9Rmm7Mqt74...

SUPERLATIVE FORMULAS: REVAMP (also comes in 20:1 concentration)HEALTH BENEFITS:Health benefits of this formula based off...
10/19/2023

SUPERLATIVE FORMULAS: REVAMP (also comes in 20:1 concentration)

HEALTH BENEFITS:
Health benefits of this formula based off studies conducted on these ingredients and observations may include but not limited to: enhanced complexion, facilitating hair growth, increased endurance, decreased fatigue, abolished stress, greater focus, anti-muscle catabolism, anti-mutagenic, anti-thrombotic, increased energy, etc.

INGREDIENTS:
1. Polyrhachis Ant
2. Ginseng Panax
3. Ginseng American
4. Reishi Mushroom
5. Cnidium Seed
6. Schizandra
7. He Shou Wu
8. Eucommia
9. Deer Antler
10. Cordyceps Mushroom
11. Astragalus
12. Gynostemma
13. Dendrobium
14. Ajuga Turkestanika
15. Mucuna pruriens
16. Chaga Mushroom
17. Pine Pollen
18. Shilajit
19. Tongkat Ali
20. Cistanche
21. Rhemania
22. Nettle Root
23. Rhodiola Root
24. Maca Root
25. Lions Mane Mushroom
26. Celastrus Seed
27. Cyanotis arachnoidea
28. Horsetail
29. Agarikon Mushroom
30. Licorice Root
31. Reishi Spores
32. Asparagus Root
33. Turkey Tail Mushroom
34. Cynomorium Root
35. Maral Root
36. Tribulus Terrestris
37. Angelica Root
38. Pine Needle
39. Star Anise
40. Fennel Seed
41. Epimedium
42. Eleuthero root

Link to page: https://superlativeformulas.com/products/superlative-50-1?variant=42432256180406

SUPERLATIVE FORMULAS: SHILAJIT (standardized at 50% fulvic acid). Shilajit is a fulvic acid rich resinous substance that...
10/02/2023

SUPERLATIVE FORMULAS: SHILAJIT (standardized at 50% fulvic acid).
Shilajit is a fulvic acid rich resinous substance that is harvested in the Himalayan mountains, offering a plethora of possible beneficial effects on the body:
1.) Enhancing cognition
2.) Immunomodulator
3.) Anti-ulcerogenic
4.) Adaptogenic/Anti stress
5.) Lowering blood sugar
6.) Antioxidant
7.) Electrolytes/minerals
8.) Increasing bioavailability of other substances.
9.) Analgesic
10.) Reproductive system
11.) Etc..
Studies highlighting the incredible health benefits that Shilajit may provide- https://superlativeformulas.com/pages/SHILAJIT

SUPERLATIVE FORMUALS: SHILAJIT extract is standardized at a highly potent 50% fulvic acid content!
Around 300 (1/8th tsp) servings in 100g bag! $75.
Message me for additional information.

Bible Directions to Heaven: https://www.youtube.com/watch?app=desktop&v=m9Rmm7Mqt74...

SUPERLATIVE FORMULAS: PINE POLLEN (Raw Wild Harvested Cracked Cell Wall)Pine pollen is a "youth powder" that may provide...
10/02/2023

SUPERLATIVE FORMULAS: PINE POLLEN (Raw Wild Harvested Cracked Cell Wall)

Pine pollen is a "youth powder" that may provide beneficial effects for the nails/skin/hair, hormone balance, libido, testosterone, energy, etc.
Multiple studies on the incredible health benefits that pine pollen may provide-https://superlativeformulas.com/pages/PINE-POLLEN

$65 for 250g bag (Approximately 80+ servings).
Message me if you have any questions.

Bible Directions to Heaven: https://www.youtube.com/watch?app=desktop&v=m9Rmm7Mqt74...

FEATURED IN SUPERLATIVE FORMULAS: ANALGESIC (200:1 concentration)Evaluation of Analgesic and Antioxidant Potential of th...
01/05/2023

FEATURED IN SUPERLATIVE FORMULAS: ANALGESIC (200:1 concentration)

Evaluation of Analgesic and Antioxidant Potential of the Leaves of Curcuma alismatifolia Gagnep.

Abstract:
“In the present study, the antioxidant and analgesic potential of the 80% methanol extract of the leaves of Curcuma alismatifolia Gangnep was evaluated. The extract was investigated for its antioxidant activity using lipid peroxidation, total antioxidant capacity and reducing power assays. The extract showed significant antioxidant activities in lipid peroxidation assay compared to the standard antioxidant in a dose dependent manner. In lipid peroxidation assay, the IC50 value was found to be 122.43μg/mL while the IC50 value for the reference ascorbic acid was 147.87μg/ml. Moreover, Curcuma alismatifolia extract showed strong total antioxidant capacity and good reducing power. The analgesic activity was evaluated for its central and peripheral pharmacological actions using tail immersion method and acetic acid-induced writhing test in mice respectively. The extract, at the dose of 250 and 500 mg/kg, produced a significant (p < 0.05-0.001) increase in pain threshold in tail immersion methods in a dose dependent manner. In acetic acid-induced writhing test the extract, at a dose of 500 mg/kg, showed a maximum of 60.5% inhibition (p < 0.001) of writhing reaction compared to the reference drug diclofenac-sodium (75.0%). All experimental results suggest the use of this plant for the treatment of pain and inflammatory disorder.” https://www.banglajol.info/index.php/sjps/article/view/1779

SUPERLATIVE FORMULAS website: https://superlativeformulas.com

page: https://www.facebook.com/profile.php?id=100075897440934

BIBLE DIRECTIONS TO HEAVEN: https://m.youtube.com/watch?v=m9Rmm7Mqt74

FEATURED IN SUPERLATIVE FORMULA (available in 20:1 and 50:1 concentrations)Antimutagenic effects of subfractions of Chag...
01/04/2023

FEATURED IN SUPERLATIVE FORMULA (available in 20:1 and 50:1 concentrations)

Antimutagenic effects of subfractions of Chaga mushroom (Inonotus obliquus) extract

Abstract:
“Inonotus obliquus is a mushroom commonly known as Chaga that is widely used in folk medicine in Siberia, North America, and North Europe. Here, we evaluated the antimutagenic and antioxidant capacities of subfractions of Inonotus obliquus extract. The ethyl acetate extract was separated by vacuum chromatography into three fractions, and the fraction bearing the highest antimutagenic activity was subsequently separated into four fractions by reversed phase (ODS-C18) column chromatography. The most antimutagenic fraction was then separated into two subfractions (subfractions 1 and 2) by normal phase silica gel column chromatography. Ames test analysis revealed that the subfractions were not mutagenic. At 50 μg/plate, subfractions 1 and 2 strongly inhibited the mutagenesis induced in Salmonella typhimurium strain TA100 by the directly acting mutagen MNNG (0.4 μg/plate) by 80.0% and 77.3%, respectively. They also inhibited 0.15 μg/plate 4NQO-induced mutagenesis in TA98 and TA100 by 52.6–62.0%. The mutagenesis in TA98 induced by the indirectly acting mutagens Trp-P-1 (0.15 μg/plate) and B(α)P (10 μg/plate) was reduced by 47.0–68.2% by the subfractions, while the mutagenesis in TA100 by Trp-P-1 and B(α)P was reduced by 70.5–87.2%. Subfraction 1 was more inhibitory than subfraction 2 with regard to the mutagenic effects of 4NQO, Trp-P-1, and B(α)P. Subfractions 1 and 2 also had a strong antioxidant activity against DPPH radicals and were identified by MS, 1H NMR and 13C NMR analyses as 3β-hydroxy-lanosta-8, 24-dien-21-al and inotodiol, respectively. Thus, we show that the 3β-hydroxy-lanosta-8, 24-dien-21-al and inotodiol components of Inonotus obliquus bear antimutagenic and antioxidative activities.” https://www.sciencedirect.com/science/article/abs/pii/S1383571808003008

SUPERLATIVE FORMULAS website: https://superlativeformulas.com

page: https://www.facebook.com/profile.php?id=100075897440934

BIBLE DIRECTIONS TO HEAVEN: https://m.youtube.com/watch?v=m9Rmm7Mqt74

FEATURED IN SUPERLATIVE FORMULAS: ANTI-OBESITY (200:1 concentration)Bitter melon (Momordica charantia L.) inhibits adipo...
01/04/2023

FEATURED IN SUPERLATIVE FORMULAS: ANTI-OBESITY (200:1 concentration)

Bitter melon (Momordica charantia L.) inhibits adipocyte hypertrophy and down regulates lipogenic gene expression in adipose tissue of diet-induced obese rats

Abstract:
“Bitter melon (Momordica charantia; BM) has been shown to ameliorate diet-induced obesity and insulin resistance. To examine the effect of BM supplementation on cell size and lipid metabolism in adipose tissues, three groups of rats were respectively fed a high-fat diet supplemented without (HF group) or with 5 % lyophilised BM powder (HFB group), or with 0·01 % thiazolidinedione (TZD) (HFT group). A group of rats fed a low-fat diet was also included as a normal control. Hyperinsulinaemia and glucose intolerance were observed in the HF group but not in HFT and HFB groups. Although the number of large adipocytes (>180 μm) of both the HFB and HFT groups was significantly lower than that of the HF group, the adipose tissue mass, TAG content and glycerol-3-phosphate dehydrogenase activity of the HFB group were significantly lower than those of the HFT group, implying that BM might reduce lipogenesis in adipose tissue. Experiment 2 was then conducted to examine the expression of lipogenic genes in adipose tissues of rats fed low-fat, HF or HFB diets. The HFB group showed significantly lower mRNA levels of fatty acid synthase, acetyl-CoA carboxylase-1, lipoprotein lipase and adipocyte fatty acid-binding protein than the HF group (P < 0·05). These results indicate BM can reduce insulin resistance as effective as the anti-diabetic drug TZD. Furthermore, BM can suppress the visceral fat accumulation and inhibit adipocyte hypertrophy, which may be associated with markedly down regulated expressions of lipogenic genes in the adipose.” https://scholar.google.com/scholar?hl=en&as_sdt=0%2C44&q=bitter+melon+obesity&oq=bitter+melon+obes =gs_qabs&t=1672830389715&u=%23p%3DnDYcIB58-xUJ

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MELASTOMA MALABATHRICUM FEATURED IN SUPERLATIVE FORMULAS: ANTI-OBESITY (200:1 concentration)Anti-Obesity Effects of Mela...
12/28/2022

MELASTOMA MALABATHRICUM FEATURED IN SUPERLATIVE FORMULAS: ANTI-OBESITY (200:1 concentration)

Anti-Obesity Effects of Melastoma malabathricum var Alba Linn in Rats Fed with a High-Fat Diet

Abstract:
“Obesity is one of the major public health problems worldwide and it is generally associated with many diseases. Although synthetic drugs are available for the treatment of obesity, herbal remedies may provide safe, natural, and cost-effective alternative to synthetic drugs. One example of such drugs is Melastoma malabathricum var Alba Linn (MM). Although several studies have been reported for the pharmacological activities of MM, there is no report on the anti-obesity effect of MM. The aim of the present study is to evaluate the anti-obesity potential of methanolic extract of MM. The anti-obesity effect of MM on rats fed with a high-fat diet was investigated through determination of the changes in body weight, fat weight, organ weights, and blood biochemicals. The animals in this study were divided into three groups: a normal group with a standard diet 👎, a control group fed with high-fat diet (C), and a MM treatment group fed with high-fat (HFD + MM) diet for 8 weeks. There was no significant difference in the amount of food intake between control and HFD + MM treatments. These results also suggest that MM does not induce a dislike for the diet due to its smell or taste. The study shows that MM significantly prevented increases in body weight, cholesterol, LDL, HDL, and total lipids that resulted from the high-fat diet. MM also decreased the epididymal fat (E-fat) and retroperitoneal fat (R-fat) weights and phospholipid concentrations induced by the high-fat diet. On the basis of these findings, it was concluded that MM had anti-obesity effects by suppressing body weight gain and abdominal fat formation.” https://link.springer.com/article/10.1208/s12249-014-0245-1

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