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Clinicians and patients call on Aperiomics to identify infectious diseases that other tests cannot identify. The only company of its kind and scope in the world, Aperiomics identifies every known pathogen (bacteria, virus, fungi or parasite) in a single test through next-generation sequencing of the DNA or RNA in any sample (patient, environmental, etc.). The complete genetic fingerprint of that sample is then compared to the Aperiomics Microbial Database™- the most comprehensive database of microorganisms, including the world’s largest collection of pathogens. This breakthrough is only possible through Aperiomics and can be used to identify unknown/chronic infections, limit the use of antibiotics and solve difficult medical cases. Patients and their families often contact Aperiomics directly after hearing about our successes in helping others. Aperiomics was named Life Sciences Innovators of the Year in 2016 and a finalist in the 2017 Greater Washington Innovation Awards. For more information, visit www.aperiomics.com or call (703) 229-0406.
Mission: To change EVERYTHING about how infections are identified!
Operating as usual
We will be presenting our Abstract at the 2020 ID Week! Come join us at our virtual booth and see our Poster#1681 on Female Urinary Metagenomic Analysis and Natural Language Processing Enhances the Infectious Diagnostic Yield in Precision Medicine #idweek2020, #Aperiomics, #DrCrystalIcenhour
I'm honored to be speaking at the 6th Annual BioHealth Capital Region Forum. Come join us, it's Free and virtual. #BHCRforum2020, #aperiomics, #DrCrystalisenhour
Aperiomics continues our series A funding round with a welcome boost from The Launch Place, a venture development organization based in Research Triangle Park, NC. We're proud to call them partners as we strive to disrupt infectious disease diagnostics:
http://www.chathamstartribune.com/news/article_2e9e8fa2-0726-11eb-8cb8-7b7a26c1bb19.html
The Launch Place, a venture development organization with offices in Danville and Research Triangle Park, N.C., has invested $150,000 from their Seed Fund II in Virginia-based healthcare startup Aperiomics. This
We had a great time at NASA's iTech competition last week! Check out our finalist presentation below to learn more about how we're pioneering infectious disease and microbiome testing:
👩🔬 🦠 🚀
https://youtu.be/uuNtosk8kBo
Aperiomics Inc. Xplore-PATHO Microbial Identification Technology Focus Area: X-Factor Innovations A technology that could identify every known microorganism,...
While investigating the impacts of the microbiome on immunity researchers have found that germ-free mice are more susceptible to systemic infection than normally colonized mice due the production of D-lactate by the gut microbiome:
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https://stke.sciencemag.org/content/13/651/eabe9388.full
Commensal-derived d-lactate promotes pathogen capture and clearance by Kupffer cells in the liver.
It's official, Aperiomics is a 2020 NASA iTech Finalist. Join us as we present with the other finalists starting today at 9am with Aperiomics presenting at 10:45am. Livestream the event from: https://livestream.com/nasaitech
RSVP at the link below:
https://www.eventbrite.com/e/2020-nasa-itech-cycle-i-forum-tickets-116112745347
We invite you to join us for the 2020 NASA iTech Cycle I Forum
It's official, Aperiomics is a 2020 NASA iTech Finalist. Join us as we present with the other finalists starting tomorrow, Oct. 1, at 9am with Aperiomics presenting at 10:45am. Livestream the event from: https://livestream.com/nasaitech
RSVP at the link below:
https://www.eventbrite.com/e/2020-nasa-itech-cycle-i-forum-tickets-116112745347
We invite you to join us for the 2020 NASA iTech Cycle I Forum
A new study published in Nature has found that treating pregnant mice with antibiotics disrupts the development of the fetal brain due to decreased gut microbiome metabolites. Supplementing several of these metabolites directly restored axon development:
https://www.sciencedaily.com/releases/2020/09/200923164601.htm
During pregnancy in mice, the billions of bacteria and other microbes that live in a mother's intestines regulate key metabolites, small molecules that are important for healthy fetal brain development, biologists report. Scientists had not known until now whether the maternal gut microbiota influen...
In a new study with mice, researchers have found that obstructive sleep apnea (OSA) reshapes the gut microbiome in a way that is transferable. Furthermore, mice receiving the OSA microbiota slept longer and more often, suggesting increased sleepiness:
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https://www.sciencedaily.com/releases/2020/09/200923124804.htm
Obstructive sleep apnea (OSA) affects more than one billion people worldwide. Evidence suggests OSA can alter the gut microbiome (GM) and may promote OSA-associated co-morbidities, including diabetes, hypertension and cognitive problems. Researchers have discovered how OSA-related sleep disturbances...
Using ~1,000 samples from the American Gut Project, researchers have found specific bacteria to be highly predictive of cardiovascular disease (CVD), opening the possibility of using a patient's gut microbiome data for yet another important health index:
https://www.sciencedaily.com/releases/2020/09/200910150336.htm
Previous studies have found the human gut microbiome, bacteria in the gastrointestinal tract, is associated with cardiovascular disease (CVD). This study used machine learning to analyze data from nearly 1,000 stool samples from people with and without CVD. Results show potential for developing a co...
Aperiomics is currently looking for a Clinical Laboratory Technologist III to join our growing team! Please follow the link below to view the position details. All qualified candidates are encouraged to apply:
https://www.indeed.com/job/clinical-laboratory-technologist-iii-50306df6eaa3dab9
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In a recent attempt to link the gut microbe to overall health, Mayo Clinic researchers have developed a Gut Microbiome Health Index using nearly 4,300 microbiome samples. This led to a healthy microbiome signature composed of 50 microbial species:
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https://www.sciencedaily.com/releases/2020/09/200915140127.htm
What causes some people to develop chronic diseases such as rheumatoid arthritis, cancer and metabolic syndrome while others stay healthy? A major clue could be found in their gut microbiome -- the trillions of microbes living inside the digestive system that regulate various bodily functions.
More than half of women will have a UTI at some point in their lives. Successful treatment hinges on correctly identifying the causative pathogen and for many tests, such our Xplore-PATHO® Urine test, that means a properly collected clean catch sample:
https://liveutifree.us16.list-manage.com/track/click?u=8a5949c3356bba5c9e8fd7798&id=e8715e82a4&e=76f6b2046a
A clean catch urine sample can mean the difference between an accurate UTI test, and 'contamination'. Learn how to collect one.
Researchers have found that warmer climates have a positive impact on bone density with implications for osteoporosis. Surprisingly, the benefit was found to be due to the effects of heat on the gut microbiome and was transferable via the microbiome:
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https://www.sciencedaily.com/releases/2020/09/200911093027.htm
Osteoporosis is characterized by a deterioration of the bones and an increased risk of fractures. With one third of postmenopausal women affected, it is a major public health problem. A research team has observed that exposure to warmer ambient temperatures increases bone strength and prevents the l...
It's official, Aperiomics is a 2020 NASA iTech Finalist 🥳
Join us as we present with the other finalists during the two-day online forum from October 1-2. NASA iTech will announce three winners as the forum wraps up on the 2nd. Hope to see you there:
https://livestream.com/nasaitech
A new study looking at the gut microbiome in Huntington's disease has found strong correlations between the two. In particular, symptomatic patients with low numbers of a species called Eubacterium hallii tended to show more severe motor symptoms:
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https://huntingtonsdiseasenews.com/2020/08/25/gut-microbiome-differs-people-with-huntingtons-or-at-disease-risk-study-says/
Microbes in the gut of people with Huntington's or likely to develop this disease appear to differ from healthy peers, opening the door to potential new biomarkers and therapeutic targets, according to a recent study. The study, "Gut dysbiosis in Huntington’s disease: associations between gut...
Join us and leaders in industry and academia as we discuss building a resilient community!
Hear from leaders addressing inclusion and diversity and the impacts for our industry at our virtual half-day conference. Get inspired about the future of our industry and the path being carved by young female leaders through mentorship. Share in opportunities for networking, discussions on leadership and life challenges, experiences in the current environment, how to “pivot” to capture those opportunities. Discover new healthcare and research policies that have changed in these unique times. Join us at the Women Building Bio Conference this September #womenbuildingbio
Researchers looking at the links between dysfunctional sleep, blood pressure, and the gut microbiome have found that consistent sleep disruptions in rats led to increases in blood pressure and more inflammatory gut microbes that were not easily reversed:
https://www.eurekalert.org/pub_releases/2020-09/uoia-urd090220.php
University of Illinois Chicago researchers have found associations among disrupted sleep, elevated blood pressure and changes in the gut microbiome.The research aimed to determine whether a 28-day period of disrupted sleep changed the microbiota in rats. The researchers also sought to identify biolo...
Using one of the fastest supercomputers in the world, researchers analyzing the genetics of COVID-19 have uncovered a new hypothesis, bradykinin storms, for how the virus is able to cause such devastating and diverse symptoms:
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https://elemental.medium.com/a-supercomputer-analyzed-covid-19-and-an-interesting-new-theory-has-emerged-31cb8eba9d63
A closer look at the Bradykinin hypothesis
Showcasing an aspect of the symbiotic nature of some gut microbiota, researchers have revealed that inositol trisphosphate, a metabolite of some commensal bacteria including E. coli, promotes epithelial barrier repair:
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https://www.nature.com/articles/s41586-020-2604-2
The coevolution of mammalian hosts and their beneficial commensal microbes has led to development of a symbiotic host-microbiota relationship1. Epigenetic machinery permits mammalian cells to integrate environmental signals2, however, how these pathways are finely tuned by diverse cues from commensa...
In one of the largest projects to date on the gut virome, researchers have found that the diversity of gut bacterial viruses, aka phages, peaks in adulthood and decreases as we age. This diversity was also correlated with overall health:
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https://www.genengnews.com/news/gut-viromes-are-highly-individualized-yet-reveal-shared-patterns/
Gut Virome Database powers metagenomic analyses and reveals age-dependent patterns of virome diversity in the human gut
A new study looking at the structure of the gut microbiome reveals how microbial communities can remain resilient despite dietary deficiencies and influence the food preferences of their hosts:
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https://www.eurekalert.org/pub_releases/2020-08/ccft-sti082420.php
To study how the microbiome affects their host behavior, a group of researchers at the Champalimaud Centre for the Unknown, in Lisbon - Portugal, used the fruit fly combined with high-tech tools to show that two gut bacteria establish a metabolic cross-feeding that enables them to grow in diets that...
While investigating new methods of vaccine delivery, researchers have found that fungal β-glucan particles loaded with Staphylococcus aureus proteins were able to induce antibodies and confer protection from S. aureus infection in mice:
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https://www.sciencedaily.com/releases/2020/08/200820143237.htm
Immunization of mice with a new vaccine consisting of fungal particles loaded with Staphylococcus aureus (S. aureus) proteins protects mice against S. aureus infection, according to a new study.
A new study looks at the links between asthma and bronchial fungal species, aka the mycobiota. Researchers concluded that fungal species complexes such as Aspergillus niger and Cryptococus humicola may play unexpected roles in the pathogenesis of asthma:
https://onlinelibrary.wiley.com/doi/abs/10.1111/cea.13722?af=R
Background Fungal involvement in asthma is associated with severe disease. The full spectrum of fungal species in asthma is not well described and is derived largely from insensitive culture techniq...
In a new study on kidney cancer and the gut microbiome, researchers have found that patients who benefited the most from cancer treatment had more gut microbiome diversity or a higher abundance of a bacterium called Akkermansia muciniphila:
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https://www.clinicalomics.com/topics/oncology/immunotherapies/greater-diversity-in-gut-microbiome-associated-with-better-cancer-immunotherapy-outcomes/
The findings showed that the greater the variety of organisms found in a patient's gut microbiome, the greater the benefit of the therapy to that patient. It also suggested that modulating the gut microbiome during treatment could affect a patient’s responses to therapy.
New research has found that the presence of certain bacteria in the microbiome, those producing a metabolite called inosine, were able to significantly increase the effectiveness of chemotherapy for several types of cancer :
https://www.sciencedaily.com/releases/2020/08/200813144920.htm
Researchers have discovered which gut bacteria help our immune system battle cancerous tumors and how they do it. The discovery may provide a new understanding of why immunotherapy, a treatment for cancer that helps amplify immune response, works in some cases, but not others. The findings show comb...
New research has found that human signaling kinases activated by malaria infection represent attractive targets for antimalarial intervention. Selective kinase inhibitors appeared particularly potent against P. falciparum and P. knowlesi in cell studies:
https://www.clinicalomics.com/news-and-features/malaria-discovery-looks-to-the-host-not-the-parasite-to-prevent-infection/
The new treatment approach offers a potential new way of warding off infection not only from malaria but other diseases caused by infectious agents, possibly including infection from SARS-CoV-2.
While higher microbiome diversity is typically associated with health in the gut microbiome, new research has found that increasing diversity in the bladder urobiome is associated with urinary incontinence:
https://www.health.harvard.edu/blog/an-emerging-link-between-the-urinary-microbiome-and-urinary-incontinence-2020081220712
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Most studies on the human microbiome have focused on the bacterial, fungal or viral communities, but archaea have largely been neglected. A new paper published in Nature Reviews Microbiology takes a closer look at the archaea that call us home:
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https://phys.org/news/2020-08-scientists-probe-role-archaea-human.html
All multicellular living beings carry an unimaginably large number of microorganisms in and on their bodies. The microbiome, i.e. the totality of these microorganisms, forms a unit together with the host organism, the so-called metaorganism. This metaorganism has developed during the course of evolu...
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A glimpse of the future...
Aperiomics is a precision pathogen testing company that is changing EVERYTHING about how infections are identified. Aperiomics’ Xplore-PATHO™ is a combination of deep metagenomic sequencing and proprietary bioinformatic analysis that can identify 37,000+ microorganisms in a single test. This cutting-edge technology is delivered as a service and detects every known bacteria, virus, parasite, and fungus.
Xplore-PATHO™ is a service that tests samples (human, animal, plant) for the presence of every known microorganism (bacteria, DNA virus, parasite, and fungi) in a single test. This platform technology has broad application across diverse markets such as clinical, agriculture, environment, industry, and veterinary. The impact of Aperiomics’ technologies is substantial due to this unique approach to microbe detection. Instead of blindly probing for a proverbial ‘needle in a haystack’, Aperiomics’ approach analyzes the entire ‘haystack’, harnessing the power of deep metagenomic sequencing and bioinformatics to identify every ‘needle’. Xplore-PATHO™ is transformative and is changing pathogen identification forever.
Existing pathogen testing, simply put, is inadequate; up to 80% of infections go undiagnosed. Undiagnosed infection costs the US economy billions each year (undiagnosed fungi alone cost $26B). Further, existing tests require one to know what they are looking for; Aperiomics’ approach identifies every known microorganism, even if you don’t know what you are looking to find. Deep sequencing is the future of pathogen testing and has already disrupted cancer testing markets. Data analysis for sequencing is often more expensive than the generation of raw sequencing data and is a major bottleneck to adoption in pathogen testing. For sequencing to reach its full potential of revolutionizing pathogen identification, data analysis must be robust, simplified, and automated. Aperiomics’ Xplore-PATHO™ does just this, providing a cost-effective method to detect 37,000+ microorganisms in ONE test.
Libby Nye - Arbonne Independent Consultant
fellows stBirth Navigator at Inova Loudoun Hospital
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