30/09/2026
TINGLING IN POTS DOESN’T ALWAYS MEAN NERVE DAMAGE 🧠⚡️
One of the symptoms patients with POTS (Postural Orthostatic Tachycardia Syndrome) complain of is tingling or “pins and needles” — particularly in the hands, face or around the mouth.
This can understandably make people worry about multiple sclerosis, peripheral neuropathy or demyelination.
But there is another important mechanism to consider:
🫁 HYPERVENTILATION → ↓ CO₂ → TINGLING
During a POTS episode, some patients develop increased respiratory drive or hyperventilation, particularly when upright, anxious or experiencing significant autonomic activation.
When you breathe out CO₂ faster than your body produces it, arterial CO₂ (PaCO₂) falls, producing respiratory alkalosis.
This change in CO₂ and blood pH can alter neuronal excitability and cerebral/peripheral blood flow and can produce very real neurological sensations, including:
• Tingling in the hands
• Perioral tingling
• Numbness or “electric” sensations
• Light-headedness
• Dizziness
• Visual symptoms
• Tremulousness
• Muscle tightness or cramping
So a patient can experience very genuine neurological symptoms without having structural demyelination of the peripheral nerves.
🔬 THIS IS WHY NERVE CONDUCTION STUDIES MATTER
I perform many NCV/NCS studies in patients with POTS and dysautonomia, and it is not uncommon for the nerve conduction studies to be normal despite significant reports of tingling, burning or altered sensation.
That distinction is important.
A normal NCV study does not mean your symptoms aren't real.
Instead, it can help demonstrate that the symptoms are not necessarily being caused by a large-fibre demyelinating or axonal peripheral neuropathy.
The clinical picture needs to be interpreted alongside:
🫀 Autonomic function
🫁 Respiratory pattern and CO₂ physiology
🧠 Central nervous system function
🩸 Blood pressure and cerebral perfusion
⚡️ Peripheral nerve conduction
🧬 Small-fibre function where clinically indicated