Cannabis Science Information

10/27/2026

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we found no evidence of an effect of cannabis on Psychoticism or any of its facets in co-twin control models that compared the greater-cannabis-using twin to the lesser-using co-twin. We also observed no evidence of a differential effect of cannabis on Psychoticism by polygenic risk of schizophrenia. Although cannabis use and disorder are consistently associated with increased risk of psychosis, the present results suggest this association is likely attributable to familial confounds rather than a causal effect of cannabis exposure.
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10/23/2026

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We show that L*D induces robust, spatially structured increases in alpha and beta peak frequencies alongside genuine attenuation of oscillatory power, with partly dissociable cortical patterns. Beyond rhythmic activity, L*D is associated with flattening of the aperiodic 1/f spectral slope and increased neural signal fractality and complexity, preferentially affecting sensory, language, emotion, and imagery-related networks while sparing motor cortex.
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Source-resolved MEG reveals that L*D speeds up and weakens alpha and beta brain rhythms while increasing neural signal complexity across sensory and emotion networks.

10/20/2026

Involvement of the endocannabinoid system in osteoarthritis pain

Osteoarthritis is a degenerative joint disease associated with articular cartilage degradation. The major clinical outcome of osteoarthritis is a complex pain state that includes both nociceptive and neuropathic mechanisms. Currently, the therapeutic approaches for osteoarthritis are limited as no d...

10/19/2026

For 15 years, James has lived through levels of pain most people can’t imagine—nerve damage, spinal issues, diverticulitis, arthritis, a near-fatal head-on collision, and a lifetime of accumulated injuries. Traditional medications brought new problems, old problems didn’t go away, and hope seemed further out of reach. Then came one moment that changed everything

For 15 years, James has lived through levels of pain most people ca...

10/15/2026

June 27, 2016
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Cannabinoids remove plaque-forming Alzheimer’s proteins from brain cells
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Founded by polio vaccine developer Jonas Salk, the Salk Institute is an independent, nonprofit organization. We drive foundational, risk-taking research that addresses society’s most pressing challenges, including cancer, Alzheimer’s, and agricultural resilience.

10/15/2026

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June 27, 2016Cannabinoids remove plaque-forming Alzheimer’s proteins from brain cells
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Founded by polio vaccine developer Jonas Salk, the Salk Institute is an independent, nonprofit organization. We drive foundational, risk-taking research that addresses society’s most pressing challenges, including cancer, Alzheimer’s, and agricultural resilience.

10/14/2026

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After adjusting for differences between the study cohorts on logistic regression, a THC(+) screen was independently associated with survival after TBI (odds ratio, 0.224; 95% confidence interval, 0.051 to 0.991; P = 0.049). A positive THC screen is associated with decreased mortality in adult patients sustaining TBI.
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Traumatic brain injury (TBI) is associated with significant morbidity and mortality. Several studies have demonstrated neuroprotective effects of cannabinoids. The objective of this study was to establish a relationship between the presence of a positive toxicology screen for tetrahydrocannabinol (T...

10/13/2026

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Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects
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1Neuropsychiatry Research Unit, Department of Psychiatry, University of Saskatchewan, Saskatoon, Saskatchewan, Canada. 2Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi’an, People’s Republic of China. 3Department of Biomedical Sciences, Dental School, Program in N...

10/09/2026

Improved Social Interaction, Recognition and Working Memory with Cannabidiol Treatment in a Prenatal Infection (poly I:C) Rat Model
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Neuropsychiatric disorders such as schizophrenia are associated with cognitive impairment, including learning, memory and attention deficits. Antipsychotic drugs are limited in their efficacy to improve cognition; therefore, new therapeutic agents are required. Cannabidiol (C*D), the non-intoxicatin...

10/08/2026

Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma
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Delta(9)-Tetrahydrocannabinol (THC) exhibits antitumor effects on various cancer cell types, but its use in chemotherapy is limited by its psychotropic activity. We investigated the antitumor activities of other plant cannabinoids, i.e., cannabidiol, cannabigerol, cannabichromene, cannabidiol acid and THC acid, and assessed whether there is any advantage in using Cannabis extracts (enriched in either cannabidiol or THC) over pure cannabinoids. Results obtained in a panel of tumor cell lines clearly indicate that, of the five natural compounds tested, cannabidiol is the most potent inhibitor of cancer cell growth (IC(50) between 6.0 and 10.6 microM),
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Delta(9)-Tetrahydrocannabinol (THC) exhibits antitumor effects on various cancer cell types, but its use in chemotherapy is limited by its psychotropic activity. We investigated the antitumor activities of other plant cannabinoids, i.e., cannabidiol, cannabigerol, cannabichromene, cannabidiol acid a...