02/18/2020
FLIPPING THE METABOLIC SWITCH: UNDERSTANDING AND APPLYING THE HEALTH BENEFITS OF FASTING
https://onlinelibrary.wiley.com/doi/full/10.1002/oby.22065
Emerging findings suggest that the metabolic switch from glucose to fatty acid‐derived ketones represents an evolutionarily conserved trigger point that shifts metabolism from lipid/cholesterol synthesis and fat storage to mobilization of fat through fatty acid oxidation and fatty acid‐derived ketones, which serve to preserve muscle mass and function. Thus, IF regimens that induce the metabolic switch have the potential to improve body composition in overweight individuals. Moreover, IF regimens also induce the coordinated activation of signaling pathways that optimize physiological function, enhance performance, and slow aging and disease processes.
METABOLIC AND MOLECULFOR THE ENHAAR FRAMEWORK NCEMENT OF ENDURANCE BY INTERMITTENT FOOD DEPRIVATION
https://www.fasebj.org/doi/abs/10.1096/fj.201701378RR
Evolutionary considerations suggest that the body has been optimized to perform at a high level in the food-deprived state when fatty acids and their ketone metabolites are a major fuel source for muscle cells.Our findings demonstrate that alternate day food deprivation engages metabolic and cellular signaling pathways that result in increased metabolic efficiency and endurance capacity.
INTERMITTENT FASTING PROMOTES ADIPOSE THERMOGENESIS AND METABOLIC HOMEOSTASIS VIA VEGF-MEDIATED ALTERNATIVE ACTIVATION OF MACROPHAGE
https://www.nature.com/articles/cr2017126
The present study uncovers the molecular mechanism of IF-mediated metabolic benefit and suggests that isocaloric IF can be a preventive and therapeutic approach against obesity and metabolic disorders.
IMPACT OF INTERMITTENT FASTING ON THE LIPID PROFILE: ASSESSMENT ASSOCIATED WITH DIET AND WEIGHT LOSS (CLINICAL NUTRITION ESPEN)
https://bit.ly/2QDOJ6T
IF can be considered an energy deficit protocol that leads to lipid profile improve by energy deficit and/or body weight reduction [13]. Hence, the caloric intake and weight loss evaluations are important to investigate the biological effects of IF on lipid profile.
INTERMITTENT METABOLIC SWITCHING, NEUROPLASTICITY AND BRAIN HEALTH
https://www.nature.com/articles/nrn.2017.156
Here, we consider how intermittent metabolic switching, repeating cycles of a metabolic challenge that induces ketosis (fasting and/or exercise) followed by a recovery period (eating, resting and sleeping), may optimize brain function and resilience throughout the lifespan, with a focus on the neuronal circuits involved in cognition and mood. Such metabolic switching impacts multiple signalling pathways that promote neuroplasticity and resistance of the brain to injury and disease.
FLIPPING THE METABOLIC SWITCH: UNDERSTANDING AND APPLYING THE HEALTH BENEFITS OF FASTING
https://onlinelibrary.wiley.com/doi/full/10.1002/oby.22065
Emerging findings suggest that the metabolic switch from glucose to fatty acid‐derived ketones represents an evolutionarily conserved trigger point that shifts metabolism from lipid/cholesterol synthesis and fat storage to mobilization of fat through fatty acid oxidation and fatty acid‐derived ketones, which serve to preserve muscle mass and function. Thus, IF regimens that induce the metabolic switch have the potential to improve body composition in overweight individuals. Moreover, IF regimens also induce the coordinated activation of signaling pathways that optimize physiological function, enhance performance, and slow aging and disease processes.
METABOLIC AND MOLECULAR FRAMEWORK FOR THE ENHANCEMENT OF ENDURANCE BY INTERMITTENT FOOD DEPRIVATION
https://www.fasebj.org/doi/abs/10.1096/fj.201701378RR
Evolutionary considerations suggest that the body has been optimized to perform at a high level in the food-deprived state when fatty acids and their ketone metabolites are a major fuel source for muscle cells.Our findings demonstrate that alternate day food deprivation engages metabolic and cellular signaling pathways that result in increased metabolic efficiency and endurance capacity.
EFFECTS OF INTERMITTENT FASTING ON GLUCOSE AND LIPID METABOLISM
https://bit.ly/2H6f91F
For IER, there is a growing evidence demonstrating its benefits on glucose and lipid homeostasis in the short-to-medium term; however, more long-term safety studies are required.
INTERMITTENT ENERGY RESTRICTION AND WEIGHT LOSS: A SYSTEMATIC REVIEW
https://www.nature.com/articles/ejcn2015195
Weight loss was achieved in overweight and obese adults following intermittent energy restriction and this loss was comparable to a daily energy restriction diet. IER may be an effective alternative strategy for health practitioners to promote weight loss for selected overweight and obese people.
INTERMITTENT V. CONTINUOUS ENERGY RESTRICTION: DIFFERENTIAL EFFECTS ON POSTPRANDIAL GLUCOSE AND LIPID METABOLISM FOLLOWING MATCHED WEIGHT LOSS IN OVERWEIGHT/OBESE PARTICIPANTS
https://bit.ly/2usXzP9
In conclusion, these preliminary findings highlight underlying differences between intermittent energy restriction and continuous energy restriction, including a superiority of intermittent energy restriction in reducing postprandial lipaemia, which now warrant targeted mechanistic evaluation within larger study cohorts.
A RANDOMIZED PILOT STUDY COMPARING ZERO-CALORIE ALTERNATE-DAY FASTING TO DAILY CALORIC RESTRICTION IN ADULTS WITH OBESITY.
https://www.ncbi.nlm.nih.gov/pubmed/27569118
No adverse effects were attributed to ADF, and 93% completed the 8-week ADF protocol. At 8 weeks, ADF achieved a 376 kcal/day greater energy deficit; however, there were no significant between-group differences in change in weight (mean ± SE; ADF -8.2 ± 0.9 kg, CR -7.1 ± 1.0 kg), body composition, lipids, or Si. After 24 weeks of unsupervised follow-up, there were no significant differences in weight regain; however, changes from baseline in % fat mass and lean mass were more favorable in ADF.
INTERMITTENT VERSUS DAILY CALORIE RESTRICTION: WHICH DIET REGIMEN IS MORE EFFECTIVE FOR WEIGHT LOSS?
https://www.ncbi.nlm.nih.gov/pubmed/21410865
These findings suggest that these diets are equally as effective in decreasing body weight and fat mass, although intermittent CR may be more effective for the retention of lean mass.
This study examined the effect of 12 wk of time-restricted feeding (TRF) on complete blood cell counts, natural killer cells, and muscle performance i…