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17/08/2026

**Why give Ringer’s Lactate to a septic patient with an already elevated lactate? 🤔**

A common concern is: *“Won’t the lactate in Ringer’s Lactate make the patient’s serum lactate even higher?”*

The short answer: **not in the way we usually worry about.**

The lactate in Ringer’s Lactate is **sodium lactate**, which is metabolized primarily by the liver (and other tissues) and can actually contribute to **bicarbonate generation**. It is not the same as the pathological lactate accumulating due to tissue hypoperfusion and impaired oxygen utilization.

So in a patient with sepsis and lactic acidosis, **the presence of lactate in the IV fluid is not, by itself, a reason to avoid Ringer’s Lactate.**

The bigger question is whether the patient needs fluid resuscitation, how much, and which crystalloid is most appropriate for the clinical situation.

💡 **Key point:** Lactated Ringer’s does contain lactate, but giving it does not simply “add to” the patient’s lactic acidosis in the way the name might suggest.

Would you use **Ringer’s Lactate or Normal Saline** in septic shock—and why?
++++++++++++++++++++++++++++++++++++
In septic shock, I’d generally favor a balanced crystalloid such as Ringer’s Lactate over 0.9% saline, assuming there’s no specific contraindication.

Why?

Less chloride: Large volumes of normal saline can cause hyperchloremia and contribute to metabolic acidosis.
Balanced crystalloids: Their electrolyte composition is closer to plasma and may be associated with better kidney-related outcomes compared with saline in critically ill patients.
The lactate in Ringer’s Lactate is not the same as pathologic lactic acidosis: It is sodium lactate and is metabolized, so it does not simply “add” to tissue-generated lactate.
But fluids should be individualized: The key issue is appropriate volume resuscitation and avoiding fluid overload—not giving unlimited crystalloid.

Important caveats: In severe hyperkalemia or certain situations involving impaired lactate metabolism, the choice may need individual consideration. Also, if hypotension persists despite appropriate fluid resuscitation, vasopressors—typically norepinephrine—should not be delayed simply to give more fluid.

So, as a practical default: Ringer’s Lactate/balanced crystalloid > normal saline for most septic-shock resuscitation.

05/08/2026
A 78-year-old man is admitted to hospital having developed abnormal movements of his left side. He has long-standing hyp...
03/08/2026

A 78-year-old man is admitted to hospital having developed abnormal movements of his left side. He has long-standing hypertension, well-controlled on atenolol, but has otherwise been healthy.
On examination of his central nervous system, he exhibits sudden, violent, involuntary flinging movements of his left arm.
What treatment should be given?
Dexamethasone
Diazepam
Selegiline
Sodium valproate
Tetrabenazine

A 56-year-old woman with a history of ischaemic heart disease, valvular heart disease (mitral stenosis), and peripheral ...
03/08/2026

A 56-year-old woman with a history of ischaemic heart disease, valvular heart disease (mitral stenosis), and peripheral vascular disease is admitted with a severe acute ischaemic stroke. She has extensive infarction of her non-dominant (right) hemisphere, resulting in a dense left hemiparesis, leaving her bedbound.

On admission, she is newly diagnosed with atrial fibrillation. A CT angiogram reveals moderate plaque in both carotid bulbs (causing 50% stenosis of the internal carotid arteries) and mild intracranial atherosclerosis. She has an intact swallow and is alert. Before this stroke, she was taking clopidogrel 75 mg daily. Due to a delayed presentation, she is not a candidate for reperfusion therapies.

What is the most appropriate immediate antithrombotic treatment for this patient once she is no longer a high risk haemorrhagic transformation?
Continue clopidogrel 75 mg daily
Start warfarin with a target INR of 2.0-3.0
Start dabigatran 150 mg twice daily
Start aspirin 300 mg daily and add dipyridamole 200 mg twice daily
Start apixaban 5 mg twice daily

03/08/2026
🧠⚡ MYASTHENIA GRAVIS: Think Beyond Simple Weakness! ⚡🧠👁️ Fluctuating ptosis?👥 Diplopia?💪 Weakness that worsens with acti...
03/08/2026

🧠⚡ MYASTHENIA GRAVIS: Think Beyond Simple Weakness! ⚡🧠

👁️ Fluctuating ptosis?
👥 Diplopia?
💪 Weakness that worsens with activity and improves with rest?
🧠 Normal sensation and reflexes?

🚨 Think Myasthenia Gravis (MG)!

This infographic provides a concise, high-yield overview of:

✅ Pathophysiology at the neuromuscular junction
✅ Characteristic clinical features
✅ Common triggers and drugs that worsen MG
✅ Diagnostic approach (AChR/MuSK antibodies, SFEMG, RNS, imaging)
✅ Management principles, including myasthenic crisis
✅ Respiratory monitoring (FVC & NIF)
✅ Clinical pearls, exam tips & common mimics

🎯 Ideal for:
👨‍⚕️ Medical Students
🩺 Residents & House Officers
📚 MRCP / FCPS / MD / MS Candidates
👩‍⚕️ General Physicians & Neurology Trainees

💡 Clinical Pearl:
Patients with fatigable ocular or bulbar weakness and normal sensation & reflexes should always prompt consideration of myasthenia gravis.

📖 Suggested Reference

Gilhus NE. Myasthenia Gravis. New England Journal of Medicine. 2016;375(26):2570–2581.

Additional evidence from:
• International Consensus Guidance for Management of Myasthenia Gravis (2020 Update)
• European Academy of Neurology (EAN) Guidelines

👍 If you found this infographic helpful:

💙 Like
💬 Comment
🔖 Save for revision
📤 Share with colleagues preparing for exams

📚 MEDICAL SCIENCE TIPS
Simplifying Medicine, One Infographic at a Time.
SCIENCE TIPS

26/02/2026

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