18/10/2026
First line: CBT should be routinely considered for severe PMS — this has strong (Grade A) evidence, it’s not just a fallback option. Certain combined pills containing a specific type of progestogen are also a genuine first-line pharmaceutical choice.
SSRIs: these are a first-line treatment for severe PMS in their own right — not just for mood disorders. They can be taken continuously or only in the two weeks before your period.
Second line: oestrogen patches combined with micronised progesterone can be highly effective by suppressing ovulation. The Mirena coil can be used alongside this to protect the womb lining.
What doesn’t work: progesterone or progestogens used alone are not an effective treatment for PMS — the evidence is clear on this.
Severe cases: GnRH analogues can be highly effective when other options haven’t worked. Surgery — removing the ovaries — is reserved as a genuine last resort.
Missed Part 1? Check my previous post for what PMS and PMDD actually are, and how they’re diagnosed.
Book a consultation at cardiffmenopauseclinic.co.uk