23/10/2026
Most of us think of oestrogen and progesterone as “cycle hormones.” But they also talk to your immune system, all day, every day.
When oestrogen and progesterone are steady, they help keep immune responses balanced. They support the cells that tell your immune system when to calm down.
In perimenopause, that steadiness goes. Progesterone usually falls first, and oestrogen starts to swing: high one month, low the next. The immune system notices. With less of that calming signal, it can lean towards a more inflammatory state.
This may help explain why:
🔹 Around 4 in 5 people with autoimmune conditions are women
🔹 That difference between men and women appears after puberty, when s*x hormones rise
🔹 Many women notice new symptoms, flares or diagnoses in their 40s, such as joint pain, thyroid changes, gut flare-ups or skin issues
🔹 Conditions like rheumatoid arthritis often change around other big hormonal shifts too, like after pregnancy
Hormones aren’t the whole story. Chronic stress disrupts your cortisol rhythm, and cortisol is one of the body’s main anti-inflammatory signals. Gut health, sleep and nutrient status (vitamin D, iron, selenium, omega-3s) all affect how your immune system copes with change.
At Wellthy, we look at the whole picture: hormones, stress, gut, nutrition and how your body is moving. Then we work out what’s actually driving your symptoms.
If you are in your 40s and your body suddenly feels like it’s working against you, it may not be in your head. It may be your immune system adjusting to a new hormonal landscape.
📍 Wellthy Clinic, Marylebone
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