21/10/2026
DR PLEASE 2/8 — R = Regular Eating
We’re trying to regulate appetite, not eliminate it.
Obesity is a chronic neuroendocrine disease involving dysregulation of appetite, satiety and food reward pathways in the brain. Much of this happens subconsciously — it’s not simply a matter of willpower.
GLP-1-based medications can help quiet these powerful biological signals.
But there’s an important distinction between reducing the pathological drivers of obesity and suppressing normal physiological hunger and appetite.
Appetite has a purpose. It helps drive adequate nutrition, enjoyment of food and quality of life.
Profound appetite suppression or aversion to food isn’t the goal of treatment. It can be an unwanted effect that needs attention.
When appetite becomes extremely reduced, people may find themselves skipping meals and relying on small amounts of convenient foods throughout the day — sometimes replacing balanced, nutritious meals they previously enjoyed.
Eating less doesn’t necessarily mean eating well. The quality and adequacy of nutrition can suffer, even when someone feels they’re responding well to medication.
Long gaps without eating can also make it harder to meet nutritional needs, while larger meals later may contribute to nausea, bloating or uncomfortable fullness.
That’s why R = Regular Eating is part of DR PLEASE — helping people maintain adequate nutrition and improve tolerability, particularly when starting treatment or increasing their dose.
The goal is better appetite regulation, not maximum appetite suppression.
A quieter appetite should improve your relationship with food and your quality of life — not compromise your nutrition.
💡 DR PLEASE is my 8-part framework of practical advice to help people get the most from obesity medications while improving tolerability, nutrition and long-term treatment sustainability.
The full guide is available free on the My Best Weight website — link in bio.
www.mybestweight.ie
If you’re regularly struggling to eat or drink enough, or experiencing persistent side effects, discuss this with your prescribing healthcare professional.