03/10/2026
Let’s chat about GLP-1 medicines and fat loss and skin changes.
If you’re taking a GLP-1 medication, whether that’s for type two diabetes, for weight management, or wider health issues, you will likely lose some weight on your face as well as your body.
These prescription only medicines don’t specifically target fat on your face. It’s just part of the overall effect of reduced calorie intake.
People ask me if they lose weight with a GLP-1 medicine, should they then add back facial volume with a dermal filler?
The aim of your GLP-1 treatment is to improve your overall health and well being.
If you’re trying to lose weight, try not to lose it too quickly.
You’re prescribing doctor will guide you, but a gradual weight loss is preferable for your facial fat and skin quality, versus rapid weight loss.
Make sure you’re getting enough protein, ideally incorporate some resistance training as well, to help preserve muscle mass, and keep up your skin care with daily SPF year round, vitamin C serum in the morning, and ideally a retinoid at night.
If you’re thinking about aesthetic treatments like dermal fillers, my advice would be, generally, wait until you’ve reached your target weight, or you’re close to it, and your way is stabilised, because otherwise, we’re treating a moving target.
And I’d much rather see what someone’s face looks like at a new baseline, and then decide together whether filler treatment is actually appropriate or not. Because not every change needs to be corrected.
The dermatology literature recognises that GLP-1-associated weight loss can produce facial volume loss, laxity, wrinkles and altered skin texture — which is why skincare is important and other options like microneedling, lasers, biostimulators and other treatments could be considered.
Talk to your aesthetic medicine professional if you’re going to be prescribed a GLP-1 medicine, and chat through how to manage potential skin and fat changes so you maintain your skin health.
Sometimes your face is simply changing because your body is changing, and that’s okay.
Take care. Eithne