OTAT Technologist

17/10/2026

16/10/2026

28/11/2025

CYTARABINE (Ara-C)

Cytarabine is a pyrimidine analogue antimetabolite widely used in the treatment of acute leukemias, especially Acute Myeloid Leukemia (AML). Inside the cell, it is converted to Ara-CTP, which incorporates into DNA and inhibits DNA polymerase, leading to chain termination and apoptosis. It is most active in the S-phase of the cell cycle.

🔹 Class

Antimetabolite – Pyrimidine analogue

🔹 Subclass

Pyrimidine antagonist

🔹 Mechanism of Action (MOA)

Converts to Ara-CTP, the active metabolite

Inhibits DNA polymerase

Incorporates into DNA → chain termination

Blocks DNA replication

Induces programmed cell death

Cell cycle–specific (S-phase)

🔹 Indications

AML induction (7+3 regimen)

Acute Lymphoblastic Leukemia (ALL)

CML blast crisis

CNS prophylaxis/therapy (intrathecal cytarabine)

🔹 Dosage

Adults:

Standard dose: 100–200 mg/m²/day IV × 7 days

High-dose Cytarabine (HiDAC): 1–3 g/m² IV q12h × 6 doses

Pediatrics:

Dose varies with protocols (ALL/AML-specific)

Intrathecal: 20–50 mg, age-based

🔹 Side Effects

Myelosuppression (dose-limiting)

Cerebellar toxicity → ataxia, slurred speech, nystagmus

Chemical conjunctivitis (requires steroid eye drops during HiDAC)

Hepatotoxicity

Tumor lysis syndrome (TLS)

GI toxicity, mucositis

Rash, fever

🔹 Contraindications

Severe bone marrow suppression

Hypersensitivity to the drug

Use with caution in:

Renal impairment

Hepatic dysfunction

Pre-existing neurological disease (↑ risk of neurotoxicity)

26/11/2025

We are delighted to announce the “Colloquium of Applied Sciences & Healthcare Research (CAHR) – 2025”, organized by Bapubhai Desaibhai Patel Institute of Allied and Healthcare Sciences (BDIAS) and P D Patel Institute of Applied Sciences (PDPIAS) at Charotar University of Science and Technology ( CHARUSAT ).
🎓 Registration Open!
📅 Date: 16–17 December 2025
🔗 Registration Link: https://docs.google.com/forms/d/e/1FAIpQLScQX9Mk5KaK9QpjqnHxM39e5eSHh0iBGmJ0Hv3HfqMkOghUTA/viewform
💳 Payment Link: https://axisbpayments.razorpay.com/pl_RcnvRSk5qZpLUB/view
📧 Abstract Submission: [email protected]
CAHR–2025 Aims
🔹 Showcase cutting-edge research
🔹 Foster interdisciplinary collaboration
🔹 Highlight innovations in Allied and Healthcare Sciences
🔹 Strengthen global research networks
Conference Objectives
Enhance collaboration, discuss diagnostic research ideas shaping the Healthcare Paradigm, promote networking.
Area
Allied & Healthcare Sciences, Biological Sciences
Which includes,
Allied and Healthcare Research, Biology Research, Infection and Inflammation, Infection Control, Pathogenesis, Molecular Diagnostics, Immunology, Phytochemistry-based Diagnostics, Cancer Biology and Diagnostics, Operation Theatre & Anaesthesia Technology, Medical Imaging Technology, Optometry.
Event Highlights
💡 Brainstorming sessions
📊 Current trends in Healthcare & Applied Sciences
🎤 Expert talks
🖼️ Scientific poster presentations
🗣️ Scientific oral presentations
Why Attend CAHR–2025
📌 Gain insights into the latest research, foster collaborations, and expand your professional network in Allied and Healthcare Sciences.
Why Submit Oral or Poster Presentations
📌 Showcase your research to experts, receive valuable feedback, and enhance your academic and professional profile.
Who Can Participate
🎓 UG/PG Students | Ph.D. Scholars | Early Career Researchers | Industry Experts | Teaching Professionals
We warmly invite all eligible participants to join this inspiring academic gathering!
🌟 Let’s come together to explore, innovate, and collaborate for a healthier and research-driven tomorrow!

Abstract for poster/oral presentation (submission guidelines):
 Word format (.docx)
 The structured abstract should be provided (Background/Introduction, Methods, Results, Discussion, and Conclusion)
 300 words maximum, including the Introduction to the conclusion
 The presenting author should be underlined and bolded
 Provide affiliation and email address for communication purposes
 Abstract submission open: 08.11.2025
 Deadline for the abstract submission: 30.11.2025

Poster presentation guidelines:
 Orientation: Portrait
 Poster size/Layout: 40” (width) x 40” (height) (100 cm x 100 cm)
 All posters to be prepared in the English language only
 Bullet points, short paragraphs can be used
 Poster Title, Name of the authors with affiliation, and abstract should be included in the poster.
 Media: only Images/photographs/tables/graphs to be included
 No videos/ multimedia