20/10/2026
How Restorative Reproductive Medicine Led to Full-Term Pregnancy After 16 Years of Infertility, Recurrent Miscarriage, and 8 Failed Embryo Transfers
This case report describes a 35-year-old Croatian woman with a complex history of subfertility, including 16 years of infertility, polycystic ovaries, and three prior pregnancy losses. She had undergone eight unsuccessful embryo transfers with in vitro fertilization and intracytoplasmic s***m injection before presenting for restorative reproductive medicine in May 2019. Initial assessment revealed poor follicular function and suboptimal progesterone levels.
Restorative reproductive medicine was initiated, an approach that emphasizes comprehensive investigation, fertility charting, and cycle optimization for up to 12 cycles to enable natural conception. The patient conceived after two treatment cycles but experienced another miscarriage at 7 weeks and 4 days. Subsequent investigations identified two critical underlying factors that had not been previously addressed: a balanced Robertsonian translocation involving chromosomes 13 and 14, and a uterine septum.
Following surgical resection of the uterine septum and ovulation induction with letrozole and human chorionic gonadotrophin, the patient underwent three additional cycles of cycle optimization. She then conceived naturally without IVF and delivered a healthy, full-term infant in 2021. The authors conclude that a thorough evaluation of hormonal, genetic, and anatomical factors combined with cycle optimization should be considered before proceeding to in vitro fertilization, particularly in cases of recurrent implantation failure and recurrent miscarriage.
Read full open access article here:
https://link.springer.com/article/10.1186/s13256-022-03465-w?
