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The US Food and Drug Administration has granted two Breakthrough Therapy Designations at once to AbbVie's experimental a...
09/10/2026

The US Food and Drug Administration has granted two Breakthrough Therapy Designations at once to AbbVie's experimental antibody-dr*g conjugate Temab-A, also called telisotuzumab adizutecan, for metastatic colorectal cancer and non-small cell lung cancer. The decision, announced on October 7, 2026, is based on early results from the first-in-human M21-404 study.

Temab-A is a next-generation c-Met-directed antibody-dr*g conjugate designed to find tumor cells and deliver a targeted cancer treatment payload directly to them. With these two designations, AbbVie's ADC portfolio now holds four Breakthrough Therapy Designations in total, one of the strongest early signals for the c-Met target in solid tumors.

The breakthrough label does not mean approval yet, but it speeds up the FDA review and gives AbbVie closer guidance as larger trials move forward. Patients and families following colorectal and lung cancer research will want to watch for the next round of study data.

Source: CURE Today (Oct 7, 2026) https://www.CureToday.com/view/fda-grants-breakthrough-therapy-designations-to-abbvies-temab-a-in-colorectal-and-lung-cancers

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A gene therapy built on Nobel Prize winning science has restored aspects of vision in people with late stage retinitis p...
09/10/2026

A gene therapy built on Nobel Prize winning science has restored aspects of vision in people with late stage retinitis pigmentosa, according to results published October 8 in the New England Journal of Medicine. GenSight Biologics reported the first in human findings of its GS030 PIONEER trial: a single intravitreal injection delivered a gene encoding the light sensitive protein ChrimsonR tdT into surviving retinal ganglion cells, bypassing the damaged photoreceptors, while special light stimulating goggles then activated the treated cells.

In the phase 1/2 study run with the 15 20 National Hospital in Paris, 6 of 10 participants showed a clinically meaningful improvement in light sensitivity. Four of 8 who completed visual behavioral testing got better at detecting, localizing or touching objects and reading bar orientations while wearing the goggles, and high density EEG in a subset showed visual signals reaching the visual cortex. The trial was not designed to prove efficacy, but these exploratory findings were consistent. Safety was reassuring: mostly mild or moderate ocular events, with one severe event resolving within minutes and no systemic adverse event linked to the dr*g or injection.

Professor José-Alain Sahel, co founder of the Institut de la Vision, called the measurable visual responses in advanced retinitis pigmentosa a particularly promising avenue for patients with very limited treatment options, while stressing the findings need confirmation. The timing is striking: the NEJM publication came just days after the 2026 Nobel Medicine Prize honored optogenetics and light gated ion channels, the same science now working inside human eyes. About 1.5 million people worldwide live with retinitis pigmentosa, and most have no approved treatment.

Source: GenSight Biologics press release (Oct 8, 2026) https://www.webdisclosure.com/press-release/gensight-biologics-sa-epa-sight-inside-information-other-news-releases-hf3NysjfztT

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A new brain cancer vaccine called SurVaxM showed promise in a Phase 2b clinical trial involving 233 glioblastoma patient...
09/10/2026

A new brain cancer vaccine called SurVaxM showed promise in a Phase 2b clinical trial involving 233 glioblastoma patients across 11 US centers. Among patients aged 65 and under, 42 percent who received the vaccine plus temozolomide were alive past 30 months, compared with 18 percent on placebo.

The subgroup also showed a median overall survival of 24.2 months versus 20.2 months, a difference researchers reported as significant at p=0.019. However, the overall study population missed its primary endpoint, with 22.8 versus 20.2 months at p=0.076, so the benefit claim stays with the younger subgroup only and this is not a cure.

Glioblastoma is one of the most aggressive forms of brain cancer, and researchers say these results support further study of the vaccine approach. Source: CancerNetwork (Oct 7, 2026) https://www.cancernetwork.com/view/novel-cancer-vaccine-plus-temozolomide-miss-primary-end-point-in-glioblastoma

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The American Academy of Pediatrics has renewed its call for a ban on raw milk sales after researchers found H5N1 bird fl...
09/10/2026

The American Academy of Pediatrics has renewed its call for a ban on raw milk sales after researchers found H5N1 bird flu surviving in refrigerated raw milk for up to five weeks. The updated warning appears in a Pediatrics policy statement presented on October 5, and it lands just as raw dairy keeps gaining popularity among health trend followers.

The academy reports that nearly half of all illnesses linked to raw dairy strike people under the age of 20, with children facing the steepest risk. The statement points to two young girls in California who were hospitalized with a severe E. coli infection traced back to raw goat milk, and it urges parents to keep unpasteurized products away from kids and pregnant women.

The position puts pediatricians in direct tension with HHS Secretary RFK Jr., who has long promoted raw milk. Pasteurization remains the standard process that removes these pathogens, and this latest clash shows the raw milk debate is far from over.

Source: News-Medical (Oct 5, 2026) https://www.news-medical.net/news/20261005/Updated-AAP-guidance-warns-raw-dairy-poses-severe-health-risks.aspx

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A new meta-analysis has pulled together the evidence on quercetin, a natural plant compound found in everyday foods like...
09/10/2026

A new meta-analysis has pulled together the evidence on quercetin, a natural plant compound found in everyday foods like apples, onions and berries, and reports it may help guard against bone loss. The findings were published in BMC Complementary Medicine and Therapies on October 6, 2026.

The researchers say the compound appears to work through three routes: antioxidant protection that calms cellular damage, redirecting stem cells toward bone-building activity, and beneficial shifts in the gut microbiome. Every study included was done in animals, so while the results are promising they remain early science, and human trials are still needed before any firm conclusions can be drawn.

Still, it is an intriguing hint that a compound already sitting in kitchen staples could one day support skeletal health, though the authors stress this is a research direction rather than a proven benefit. Nothing about this work should be read as medical advice or as a treatment recommendation.

Source: ScienMag (Oct 6, 2026) https://scienmag.com/quercetin-shows-promise-against-bone-loss-in-animal-studies-meta-analysis-finds/

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A large new study from McMaster University has found a striking link between reproductive health problems in adolescence...
09/10/2026

A large new study from McMaster University has found a striking link between reproductive health problems in adolescence and pain in adulthood. Researchers followed nearly 500,000 Ontarians and found that teenage girls who sought care for gynecologic or reproductive health concerns faced a 41 percent higher rate of chronic pelvic pain later in life, according to findings published October 6 in The Lancet Regional Health Americas.

The numbers are hard to ignore. By ten years into adulthood, 28 percent of those who had sought care for such problems as teens were living with chronic pelvic pain, compared with about 15 percent of those who had not. The study also found that teens who received care for more than one gynecologic concern faced even greater risk, suggesting that early reproductive health issues may be an early signal worth closer long term attention.

Researchers say the results point to adolescence as a window where early care and consistent follow up could change the course of chronic pain years later. The team hopes the findings will encourage clinicians to take teenage reproductive health concerns seriously and to track them as a possible early marker of future pelvic pain.

Source: Medical Xpress (Oct 6, 2026) https://medicalxpress.com/news/2026-10-early-chronic-pelvic-pain-adolescence.html

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Scientists have produced the first single cell mitochondrial DNA analysis of Parkinson's disease, and it shows how the c...
09/10/2026

Scientists have produced the first single cell mitochondrial DNA analysis of Parkinson's disease, and it shows how the condition damages the power plants inside brain cells. Researchers from the University of Birmingham and Newcastle University found extensive deletions in the major arc energy region inside the exact brainstem neurons lost in Parkinson's.

The study, published in the journal Brain on Oct 7, mapped the damage in striking detail, showing which cells carry the heaviest energy losses. A protective PINK1 response was strongest in the longest surviving neurons, which the team says could point to a brand new target for future treatments.

The findings do not change treatment today, but they give researchers the most precise picture yet of how Parkinson's wears down the cell's energy supply. That map could guide the search for therapies that protect these vulnerable neurons. (Source: Medical Xpress, Oct 7, 2026: https://medicalxpress.com/news/2026-10-cell-dna-analysis-reveals-mitochondrial.html)

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A new study from Northwestern University found that years of opioid use did not reduce pain or improve daily functioning...
09/10/2026

A new study from Northwestern University found that years of opioid use did not reduce pain or improve daily functioning in people with chronic back pain. Researchers compared 70 long term opioid users with 70 matched non users and reported no meaningful difference in how the two groups felt or functioned.

The findings, published in the journal Brain on Oct 1, 2026, challenge the long standing assumption that ongoing opioid prescriptions control persistent back pain. The team also found the users' brains were largely intact and identified new serotonin receptor markers that could guide future pain and tapering treatments.

The researchers say the results do not tell anyone what to do about their own medication, and they urge patients to talk with their own doctors about their care. The study simply adds evidence that long term opioids may not deliver the relief many hoped for. (Source: Medical Xpress, Oct 1, 2026: https://medicalxpress.com/news/2026-10-years-opioid-chronic-pain.html)

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Researchers at the University of Osaka have discovered that when a child's teeth fall out unusually early, it can be the...
09/10/2026

Researchers at the University of Osaka have discovered that when a child's teeth fall out unusually early, it can be the first sign of a rare inherited bone disorder called hypophosphatasia. In mouse models of the disease, early tooth loss appeared before other symptoms and was sometimes the only warning signal of the hidden condition.

The study, published in the journal JBMR Plus, also showed that different gene variants caused different dental defects, even when the rest of the skeleton looked almost normal. That means the mouth may reveal what bone scans miss, and a simple dental exam could one day help flag this rare disease sooner.

The findings point to a new way for doctors and dentists to recognize hypophosphatasia early, which could matter because early awareness of a rare disorder helps families plan care. More research is needed before this changes any routine checkups. (Source: Medical Xpress, Oct 6, 2026: https://medicalxpress.com/news/2026-10-teeth-reveal-hidden-rare-bone.html)

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Scientists have found a bl00d protein that can flag Alzheimer damage an astonishing 21 years before any symptom appears....
08/10/2026

Scientists have found a bl00d protein that can flag Alzheimer damage an astonishing 21 years before any symptom appears. In a study of people with Down syndrome, who face a much higher risk of Alzheimer, levels of a protein called beta synuclein started rising two decades before memory problems began, according to researchers at Sant Pau in Barcelona.

The finding, published in the journal Alzheimer and Dementia, moves the earliest detectable warning even earlier than other bl00d markers being studied today. Because the protein reflects failing connections between brain cells, it may reveal the very first stage of brain decline long before any test could have caught it.

A simple bl00d test for this protein could one day help doctors spot risk decades ahead and start protective steps sooner. The research is still early and was done in a high risk group, but it opens a powerful new window for Alzheimer detection and future prevention trials.

Source: Medical Xpress (Oct 7, 2026) https://medicalxpress.com/news/2026-10-blood-marker-flag-alzheimer-syndrome.html
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