10/17/2026
Burning. Tingling. Shooting. Electric-shock sensations.
Neuropathic pain can feel very different from inflammatory or muscular pain-and the treatment approach can be different too.
That’s why some prescribers explore topical therapies that act through more than one mechanism. Clinical research has examined ingredients such as lidocaine, amitriptyline and ketamine in topical neuropathic-pain formulations, although results across studies are mixed.
So this isn’t about putting every possible pain medication into one cream.
It’s about asking:
✔ What kind of pain is this?
✔ Where is it located?
✔ What has already been tried?
✔ Which ingredients are appropriate for this patient?
When a prescriber determines that a patient-specific formulation is appropriate, Alpine can compound the prescribed strength, combination and dosage form.