JAMA Cardiology

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11/09/2023

In myeloma patients undergoing hematopoietic stem transplant (HCT), clonal hematopoiesis of indeterminate potential (CHIP) was highly prevalent at baseline & associated w/ a significantly increased risk of CVD after HCT.

In adults who have undergone the Ross procedure using a freestanding root technique, survival into the 3rd decade is exc...
11/08/2023

In adults who have undergone the Ross procedure using a freestanding root technique, survival into the 3rd decade is excellent and comparable to that of the matched general population. https://ja.ma/3soTc6f

Case report: a diagnosis of double inlet left ventricle in a 58-year-old man without prior heart surgery presenting with...
11/08/2023

Case report: a diagnosis of double inlet left ventricle in a 58-year-old man without prior heart surgery presenting with NYHA class III heart failure.

This case report discusses the diagnosis of double-inlet left ventricle in a male adult patient in his 50s who presented with New York Heart Association class III heart failure.

Case report: an erroneous rapid exchange balloon inflation during coronary angioplasty in a patient who presented with a...
11/07/2023

Case report: an erroneous rapid exchange balloon inflation during coronary angioplasty in a patient who presented with a right coronary artery lesion on angiography.

This case report discusses an erroneous rapid exchange balloon inflation during coronary angioplasty in a patient who presented with a right coronary artery lesion on angiography.

Insulin resistance is associated with N-terminal pro-B-type natriuretic peptide independently of measures of body compos...
11/06/2023

Insulin resistance is associated with N-terminal pro-B-type natriuretic peptide independently of measures of body composition (including DEXA -derived measures of fat mass and lean mass).

This cross-sectional study examines the association between insulin resistance and N-terminal pro-B-type natriuretic peptide in adults without diabetes or cardiovascular disease based on body composition measures.

11/03/2023

This cross-sectional study compares the prevalence, awareness, and treatment of elevated low-density lipoprotein cholesterol in US adults in 1999-2000 vs 2017-2020.

Results suggest that additional regulation of the claims made on fish oil supplement labels may be needed to prevent con...
11/03/2023

Results suggest that additional regulation of the claims made on fish oil supplement labels may be needed to prevent consumer misinformation.

This cross-sectional study investigates the health claims made on the labels of fish oil supplements and the total daily dose of eicosapentaenoic acid and docosahexaenoic acid in commonly available fish oil supplements.

In the MANIFEST-PF registry, including 1,568 atrial fibrillation pts (65% PAF / 35% PerAF), there were no significant di...
11/02/2023

In the MANIFEST-PF registry, including 1,568 atrial fibrillation pts (65% PAF / 35% PerAF), there were no significant differences in 1-yr clinical effectiveness (79% vs 76.3%, p=0.28) or safety events (1.5% vs 2.5%, p=0.19) between men and women. https://ja.ma/3FHLVBB

Changes in coronary venous pressure led to a decrease in coronary microvascular resistances in a randomized, sham-contro...
11/02/2023

Changes in coronary venous pressure led to a decrease in coronary microvascular resistances in a randomized, sham-controlled study in patients with microvascular angina. The implications for chronic therapy deserve investigation. https://ja.ma/3ZVh0ej

11/01/2023

Results from this study provide critical perspective on cardiovascular disease and its association with educational attainment; educational opportunity in early life may have lasting effects in middle age and older age.

Editorial: Long-Term Efficacy and Safety of Mavacamten in Symptomatic Patients With Obstructive Hypertrophic Cardiomyopa...
10/31/2023

Editorial: Long-Term Efficacy and Safety of Mavacamten in Symptomatic Patients With Obstructive Hypertrophic Cardiomyopathy.

Cardiac myosin inhibitors are a novel class of drugs developed to target the underlying molecular defect of hyperactivation of the cardiac sarcomere in patients with hypertrophic cardiomyopathy (HCM).1 The first in class, mavacamten, received US Food and Drug Administration (FDA) approval in 2022...

Study found that for patients with symptomatic obstructive HCM, there is sufficient and sustained improvement with mavac...
10/30/2023

Study found that for patients with symptomatic obstructive HCM, there is sufficient and sustained improvement with mavacamten, thereby reducing the need for SRT and representing a useful therapeutic option for patients.

This randomized clinical trial investigates the long-term efficacy of mavacamten in reducing the need for septal reduction therapy in patients with obstructive hypertrophic cardiomyopathy.

In clinical trial, mavacamten significantly improved Valsalva left left ventricular outflow gradient vs placebo in Chine...
10/27/2023

In clinical trial, mavacamten significantly improved Valsalva left left ventricular outflow gradient vs placebo in Chinese patients. Study supports the efficacy and safety of mavacamten in diverse populations, including Chinese patients. https://ja.ma/3rLWHDC

This study assesses the incremental predictive value of a modified Global Registry of Acute Coronary Events score incorp...
10/27/2023

This study assesses the incremental predictive value of a modified Global Registry of Acute Coronary Events score incorporating high-sensitivity cardiac troponin T at presentation, a surrogate of the extent of myocardial injury.

This cohort study assesses the incremental predictive value of a modified Global Registry of Acute Coronary Events score incorporating high-sensitivity cardiac troponin T at presentation, a surrogate of the extent of myocardial injury.

Over 200 health journals call on the United Nations, political leaders, and health professionals to recognize that clima...
10/26/2023

Over 200 health journals call on the United Nations, political leaders, and health professionals to recognize that climate change and biodiversity loss are one indivisible crisis and must be tackled together to preserve health and avoid catastrophe. https://ja.ma/45LwumB

Myocardial viability testing does not identify patients with ischemic cardiomyopathy who benefit from PCI. Findings sugg...
10/25/2023

Myocardial viability testing does not identify patients with ischemic cardiomyopathy who benefit from PCI. Findings suggest that the extent of dysfunctional yet viable myocardium was not associated with revascularization outcomes. https://ja.ma/3Mbcrak

In this meta-analysis, regression of atherosclerotic plaque by 1% was associated with a 25% reduction in the odds of MAC...
10/24/2023

In this meta-analysis, regression of atherosclerotic plaque by 1% was associated with a 25% reduction in the odds of MACEs. Findings suggest that change in PAV could be a surrogate marker for MACEs but additional data are needed.

This systematic review and meta-regression evaluates the association between coronary plaque regression induced by lipid-lowering therapies and major adverse cardiovascular events.

Findings suggest the incidence of hypertension and elevated hsCRP, but not other cardiovascular risk factors, is increas...
10/23/2023

Findings suggest the incidence of hypertension and elevated hsCRP, but not other cardiovascular risk factors, is increased among US adults with childhood exposure to parental incarceration.

This cohort study examines the association of childhood exposure to parental incarceration with cardiovascular risk among a nationally representative sample of US adults.

A woman in her 90s presented to the emergency department with fever, hemoptysis, and syncopal episodes. An electrocardio...
10/20/2023

A woman in her 90s presented to the emergency department with fever, hemoptysis, and syncopal episodes. An electrocardiogram showed monomorphic ventricular tachycardia with a morphology suggesting right ventricular (RV) origin. What would you do next?

A woman in her 90s presented to the emergency department with fever, hemoptysis, and syncopal episodes. An electrocardiogram showed monomorphic ventricular tachycardia with a morphology suggesting right ventricular (RV) origin. What would you do next?

A minority of patients w/ cardiac implantable electronic device (CIED) infection undergo extraction. Earlier extraction ...
10/19/2023

A minority of patients w/ cardiac implantable electronic device (CIED) infection undergo extraction. Earlier extraction is associated w/ a significantly lower risk of death. There is a need to improve guideline-directed care of patients with CIED infection.

This cohort study uses Medicare data to assess the number of patients with cardiac implantable electronic device infection who underwent device extraction from 2006 to 2019 and all-cause mortality associated with lead extraction.

Findings support the concept that deferred testing is safe in those identified as being at minimal risk for coronary art...
10/17/2023

Findings support the concept that deferred testing is safe in those identified as being at minimal risk for coronary artery disease, while reducing the number of low-yield diagnostic tests.

This study assesses process of care and health outcomes in people identified as minimal risk for coronary artery disease when testing is deferred.

For stable chest pain patients, a precision strategy of quantitative risk assessment with deferred testing or CTA±FFRCT ...
10/16/2023

For stable chest pain patients, a precision strategy of quantitative risk assessment with deferred testing or CTA±FFRCT is superior to usual testing for death, MI and cath without obstructive CAD at 1 year. https://ja.ma/45tGalB

JAMA and 10 JAMA Network journals issue a Call for Papers to solicit rigorous empirical research on election-year health...
10/13/2023

JAMA and 10 JAMA Network journals issue a Call for Papers to solicit rigorous empirical research on election-year health and health care issues and policies across the populations and medical specialties represented by the journals. Read the full editorial.

Nationally and globally, health will continue to be one of the most important policy issues for the 2024 US election. Information about these health issues is critical for decision-making and to answer pressing public and global health questions affecting the US and the world.1,2 US elections are...

This study reveals promising results for cardio-oncology rehab among high-risk cancer survivors. Center-based cardiac re...
10/12/2023

This study reveals promising results for cardio-oncology rehab among high-risk cancer survivors. Center-based cardiac rehab (CBCR) showed superior cardiorespiratory fitness & cardiovascular risk control compared to community-based exercise training (CBET). https://ja.ma/3PTRVvE

Cascade screening of first-degree relatives of individuals with high lipoprotein(a) levels, if implemented at scale, is ...
10/11/2023

Cascade screening of first-degree relatives of individuals with high lipoprotein(a) levels, if implemented at scale, is likely to identify a substantial number of additional high-risk individuals.

This cross-sectional study measures the association of lipoprotein(a) concentrations in pairs of first- and second-degree relatives of participants in the UK Biobank with high lipoprotein(a) levels.

Case report discusses a finding of blood in the pericardiocentesis catheter of a patient with a recent history of aortic...
10/10/2023

Case report discusses a finding of blood in the pericardiocentesis catheter of a patient with a recent history of aortic valve replacement and recurrent postsurgical pericardial and pleural effusions. https://ja.ma/3PSWiIB

Review assesses adenosine triphosphate citrate lyase inhibition with bempedoic acid as therapy in high-risk patients who...
10/09/2023

Review assesses adenosine triphosphate citrate lyase inhibition with bempedoic acid as therapy in high-risk patients who require further low-density lipoprotein cholesterol lowering.

This Narrative Review assesses adenosine triphosphate citrate lyase inhibition with bempedoic acid as therapy in high-risk patients who require further low-density lipoprotein cholesterol lowering.

10/05/2023

Case report: a diagnosis of intravenous leiomyomatosis in a woman in her 50s who presented with exertional dyspnea and syncope and had a history of hysteromyomectomy.

10/04/2023

A secondary analysis from the ADAPTABLE study showed that enteric coated aspirin had the same effectiveness and safety (as measured by all-cause death, myocardial infarction or stroke major or gastrointestinal bleeding) as plain aspirin.

Women and racial and ethnic minority individuals remain underrepresented in North American valvular heart disease clinic...
10/03/2023

Women and racial and ethnic minority individuals remain underrepresented in North American valvular heart disease clinical trials with few trials reporting data on the race and ethnicity of trial participants.

This systematic review analyzes data reported from clinical trials studying treatments for valvular heart disease to determine trends in the representation of older patients, women, and racial and ethnic minority individuals among these trial participants.

Combination cohort and case-crossover study evaluates the association between fluoroquinolone use and hospitalization wi...
10/02/2023

Combination cohort and case-crossover study evaluates the association between fluoroquinolone use and hospitalization with aortic aneurysm or aortic dissection.

This combination cohort and case-crossover study evaluates the association between fluoroquinolone use and hospitalization with aortic aneurysm or aortic dissection.

The All of Us Research Program addresses historical underrepresentation of racial and ethnic populations in US research,...
09/29/2023

The All of Us Research Program addresses historical underrepresentation of racial and ethnic populations in US research, most notably in Black participants with varying geographic trends in Asian, Hispanic, White, and multiracial participants.

This cohort study investigates the racial and ethnic diversity of the All of Us Research Program compared with the racial and ethnic diversity of the US population.

The addition of posterior wall isolation to pulmonary vein isolation for initial catheter ablation in patients with pers...
09/28/2023

The addition of posterior wall isolation to pulmonary vein isolation for initial catheter ablation in patients with persistent atrial fibrillation and symptomatic heart failure with reduced ejection fraction does not improve freedom from atrial arrhythmia.

This secondary analysis of a randomized clinical trial examines whether adding posterior wall isolation to pulmonary vein isolation improves outcomes in patients with heart failure (HF) with reduced ejection fraction and atrial fibrillation (AF).

Sadiya Sana Khan, MD, MSc, Muthiah Vaduganathan, MD, MPH, and John W. Ostrominski, MD, discuss "Prevalence and Overlap o...
09/28/2023

Sadiya Sana Khan, MD, MSc, Muthiah Vaduganathan, MD, MPH, and John W. Ostrominski, MD, discuss "Prevalence and Overlap of Cardiac, Renal, and Metabolic Conditions in US Adults, 1999-2020."

Interview with Muthiah Vaduganathan, MD, MPH, and John W. Ostrominski, MD, authors of Prevalence and Overlap of Cardiac, Renal, and Metabolic Conditions in US Adults, 1999-2020. Hosted by Sadiya Sana Khan, MD, MSc.

Sacubitril/valsartan vs. ACEI/ARB is consistent with high economic value for patients inclusive of reduced and mildly re...
09/27/2023

Sacubitril/valsartan vs. ACEI/ARB is consistent with high economic value for patients inclusive of reduced and mildly reduced ejection fractions (EF≤50%) and at least intermediate value at the current undiscounted WAC price at an EF≤60%.

This economic evaluation examines the cost-effectiveness of sacubitril-valsartan among a range of ejection fractions and at different upper-level cutoffs of below-normal ejection fractions.

In this National Health and Nutrition Examination Survey analysis, cardio-renal-metabolic multimorbidity was substantial...
09/27/2023

In this National Health and Nutrition Examination Survey analysis, cardio-renal-metabolic multimorbidity was substantial (~1 in 10 US adults; ~1 in 4 aged ≥65 years), increasing over time, and undertreated. Collaborative prevention and treatment efforts are critically needed in this population.

This cohort study investigates the prevalence and overlap of cardiac, renal, and metabolic conditions in US adults, using data from the National Health and Nutrition Examination Survey.

Ezetimibe combination with moderate-intensity statin could be considered a feasible and effective therapeutic option for...
09/26/2023

Ezetimibe combination with moderate-intensity statin could be considered a feasible and effective therapeutic option for patients at very high risk of atherosclerotic cardiovascular disease.

This post hoc analysis of the Randomized Comparison of Efficacy and Safety of Lipid Lowering With Statin Monotherapy vs Statin/Ezetimibe Combination for High-Risk Cardiovascular Disease (RACING) randomized clinical trial investigates if a moderate-intensity statin plus ezetimibe combination therapy....

Changes in myocardial native T1 may be used in the clinical setting to track treatment response in cardiac light-chain a...
09/25/2023

Changes in myocardial native T1 may be used in the clinical setting to track treatment response in cardiac light-chain amyloidosis.

This cohort study assesses whether native T1 mapping can measure the cardiac light-chain amyloidosis treatment response and the association between changes in native T1 and prognosis.

The findings of this study suggest that women who gave birth after assisted reproductive technologies (ART) were not at ...
09/22/2023

The findings of this study suggest that women who gave birth after assisted reproductive technologies (ART) were not at increased risk of CVD over a median follow-up of 11 years compared with those who conceived without ART.

This cohort study assesses the association between use of assisted reproductive technologies and risk of cardiovascular disease among parous women.

One-year follow-up of the TOMAHAWK trial showing no benefit for immediate angiography in   without ST-segment elevation....
09/21/2023

One-year follow-up of the TOMAHAWK trial showing no benefit for immediate angiography in without ST-segment elevation. Mortality in the immediate angiography group even numerically higher compared to a delayed/selective strategy. https://ja.ma/3EAMiNV

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