JAMA Cardiology

10/23/2026

💬 Editorial: For stroke prevention in , may be reasonable for patients who cannot tolerate long-term oral anticoagulation, but its net clinical benefit remains uncertain for those who can. These findings indicate that treatment decisions should weigh the competing risks of ischemic stroke, bleeding, and procedural complications.

10/22/2026

This case report discusses a finding of McConnell sign on echocardiography in a man in his 60s who presented for evaluation after a syncopal episode.

This case report discusses a finding of McConnell sign on echocardiography in a man in his 60s who presented for evaluation after a syncopal episode.

10/22/2026

💬 Editorial by Marianna Fontana, MD, PhD, Julian Gillmore, MD, PhD, and Scott David Solomon, MD: In , risk prediction is shifting from static staging at diagnosis toward models that incorporate treatment status and better reflect prognosis in contemporary treated populations. This editorial indicates that machine learning-based prediction improved discrimination compared with National Amyloidosis Centre and Mayo staging systems and may support more granular baseline risk assessment.

Risk stratification in transthyretin amyloid cardiomyopathy (ATTR-CM) has long relied on 2 staging systems developed more than a decade ago, the National Amyloidosis Centre (NAC)1,2 and Mayo staging systems,3 both built on cardiac biomarkers and kidney function. They have served the field well,...

10/21/2026

💬 Editorial: Evidence on indicates that va**ng is associated with respiratory and vascular harm, while high-ni****ne products, flavors, and marketing can rapidly establish ****ne addiction, especially among youth.

https://ja.ma/3U4d24J

10/21/2026

📊 Among young adults without established cardiovascular risk factors, regular daily ****neVape use was associated with lower vascular function and lower cardiorespiratory fitness compared with to***co- and ni****ne v**e-naive individuals.

Similar impairments in vascular function were observed among adults who used combustible ci******es, indicating that regular ni****ne v**e use was associated with an unfavorable cardiovascular profile in this low-risk population.

https://ja.ma/4i0ybG3

10/21/2026

📝 Viewpoint: Suboptimal diet remains a leading modifiable contributor to , and prevention strategies should emphasize healthier dietary patterns, lower sodium intake, and prevention of .

https://ja.ma/4eMi1ho

10/21/2026

🫀📊 Viewpoint: Closing evidence gaps in maternal will require longitudinal, patient-partnered research models embedded in routine care rather than continued reliance on small specialist-center cohorts. The UK-wide PREG-HEART model supports linkage of maternal and offspring health data and may help improve evidence generation across pregnancy, postpartum care, and longer-term outcomes.

This Viewpoint explores the evidence gap around maternal cardiovascular disease and advocates for a more coordinated, patient-centered, and longitudinal approach to research to address this gap.

10/20/2026

Serial cardiovascular magnetic resonance imaging in patients with Transthyretin amyloid cardiomyopathy indicated that was associated with directionally favorable changes over 36 months, including less amyloid progression and amyloid regression in a minority of treated patients. These findings complement the HELIOS-B trial and suggest imaging-based value for tracking treatment-related changes in myocardial amyloid burden.

This cohort study investigates if vutrisiran treatment was associated with longitudinal changes in cardiac structure, function, and amyloid burden in patients with transthyretin amyloid cardiomyopathy who were assessed with cardiovascular magnetic resonance imaging (MRI).

10/19/2026

📊 Among patients with treated with immune checkpoint inhibitors, vascular endothelial growth factor inhibitors, or both, positron emission tomography computed tomography did not detect increased arterial inflammation at 24 weeks. These findings indicate that macrophage-driven plaque activation may not be the main mechanism of treatment-associated atherothrombosis and support further study of endothelial and thrombotic pathways.

This cohort study examines the arterial and systemic inflammatory outcomes associated with immune checkpoint inhibitors and vascular endothelial growth factor inhibitors using positron emission tomography (PET).

10/18/2026

🫀📈 Among patients with with cardiomyopathy, impaired left atrial function measured by strain was associated with higher risk of death, recurrent cardiovascular events, heart failure hospitalization, and incident atrial fibrillation. These findings indicate that left atrial dysfunction may provide prognostic information beyond conventional measures of cardiac structure.

This secondary analysis of the HELIOS-B randomized clinical trial evaluates the prognostic significance of left atrial structure and function among patients with transthyretin amyloidosis with cardiomyopathy and assesses the effects of vutrisiran on these parameters.