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In fall-winter 2023-2024, the risk of death in patients hospitalized for COVID-19 was greater than the risk of death in ...
06/16/2024

In fall-winter 2023-2024, the risk of death in patients hospitalized for COVID-19 was greater than the risk of death in patients hospitalized for seasonal influenza.

This cohort study evaluates the risk of death in patients hospitalized for COVID-19 or seasonal influenza following the emergence of the JN.1 variant in winter 2023.

This JAMA Insights in the Communicating Medicine series explores the concept of “prebunking,” a psychological inoculatio...
06/15/2024

This JAMA Insights in the Communicating Medicine series explores the concept of “prebunking,” a psychological inoculation technique that could help prevent the spread of misinformation. https://ja.ma/3xcHjCZ

Most viewed in the last 7 days from JAMA: Is there a difference in mortality between continuous and intermittent infusio...
06/15/2024

Most viewed in the last 7 days from JAMA: Is there a difference in mortality between continuous and intermittent infusions of β-lactam antibiotics in critically ill patients with sepsis?

https://ja.ma/3XGP0MH

Increasingly, public health experts have recognized that testing and treatment alone won’t curb the more-than-decade-lon...
06/14/2024

Increasingly, public health experts have recognized that testing and treatment alone won’t curb the more-than-decade-long rise of US syphilis cases, which in 2022 reached the highest number since 1950, according to the CDC. https://ja.ma/4aXo660

Most viewed in the last 7 days from JAMA: This Viewpoint explores the effects of weight loss achieved through GLP-1–base...
06/14/2024

Most viewed in the last 7 days from JAMA: This Viewpoint explores the effects of weight loss achieved through GLP-1–based antiobesity medications on weight regain, fat-free mass, and skeletal muscle mass in people with obesity.

https://ja.ma/3Vwvj8w

In randomized clinical trials of cancer screening, incidence of late-stage cancer may be a suitable alternative end poin...
06/14/2024

In randomized clinical trials of cancer screening, incidence of late-stage cancer may be a suitable alternative end point to cancer-specific mortality for some cancer types, but is not suitable for others. https://ja.ma/3VmS8dP

JAMA Clinical Challenge update. Read this article to learn the answer to yesterday's challenge.https://ja.ma/3z1Hsty
06/14/2024

JAMA Clinical Challenge update.

Read this article to learn the answer to yesterday's challenge.

https://ja.ma/3z1Hsty

Cardiovascular biomarkers were strongly associated with fatal and nonfatal cardiovascular events and mortality. https://...
06/14/2024

Cardiovascular biomarkers were strongly associated with fatal and nonfatal cardiovascular events and mortality. https://ja.ma/4b1j4Fs

Among individuals with a CDH1 gene variant, the risk of gastric cancer was lower than previously described, while risk o...
06/14/2024

Among individuals with a CDH1 gene variant, the risk of gastric cancer was lower than previously described, while risk of female breast cancer was similar to previous estimates.

https://ja.ma/4efjZVX

Editorial: Sodium-Glucose Cotransporter 2 Therapy for Acute Organ Dysfunction https://ja.ma/45vpiwj
06/14/2024

Editorial: Sodium-Glucose Cotransporter 2 Therapy for Acute Organ Dysfunction

https://ja.ma/45vpiwj

The addition of dapagliflozin to standard care for individuals with critical illness and acute organ dysfunction did not...
06/14/2024

The addition of dapagliflozin to standard care for individuals with critical illness and acute organ dysfunction did not improve clinical outcomes.

https://ja.ma/45pKXGn

Viewpoint discusses ways to ensure the proficiency of bilingual communication among health care staff in patient-clinici...
06/13/2024

Viewpoint discusses ways to ensure the proficiency of bilingual communication among health care staff in patient-clinician encounters, such as language testing and use of professional interpreters.

This Viewpoint discusses ways to ensure the proficiency of bilingual communication among health care staff in patient-clinician encounters, such as language testing and use of professional interpreters.

Naloxone prescriptions dispensed from retail pharmacies increased from 2019 to 2023, with the largest single-year increa...
06/13/2024

Naloxone prescriptions dispensed from retail pharmacies increased from 2019 to 2023, with the largest single-year increase observed in 2022. This increase may reflect efforts to expand naloxone prescribing, including state-level standing orders and clinical practice guidelines. https://ja.ma/3ySXKVl

Take the JAMA Clinical Challenge73-year-old man presented to the oculoplastics clinic with a 5-day history of a rapidly ...
06/13/2024

Take the JAMA Clinical Challenge

73-year-old man presented to the oculoplastics clinic with a 5-day history of a rapidly growing right eyebrow lesion. The lesion was not causing substantial discomfort, and the patient denied additional symptoms, including vision changes.

He had a large erythematous nodule with raised borders under the right brow with central ulceration that was draining clear material. Based on the rapid presentation and clinical appearance, the lesion was hypothesized to be a brow abscess.

Patient was prescribed clindamycin and erythromycin ointment, instructed to start warm compresses to promote abscess drainage and healing, and told to follow up in 1 week. After 1 week, the lesion continued to enlarge.

What would you do next? Comment your answer below.

A. Observe with no action
B. Biopsy of lesion
C. Corticosteroid injection
D. Trial another antibiotic

Friday at 12 pm ET we’ll post the answer.

Editorial: Although promising, these grassroots efforts are no substitute for effective reform to address high costs, sh...
06/13/2024

Editorial: Although promising, these grassroots efforts are no substitute for effective reform to address high costs, shortages, overcommercialization, and other failures in the US pharmaceutical market. https://ja.ma/4ciRtkb

A decision by commercial and Medicare plans to increase naloxone cost sharing by $10 would be associated with a 3.1- and...
06/13/2024

A decision by commercial and Medicare plans to increase naloxone cost sharing by $10 would be associated with a 3.1- and 2.3-percentage-point increase in the probability of prescription abandonment, respectively. https://ja.ma/4efq5Wh

As the number of vaccines for adults grows, manufacturers have begun working on combining some of them into a single inj...
06/13/2024

As the number of vaccines for adults grows, manufacturers have begun working on combining some of them into a single injection. This Medical News story discusses the development of experimental combination vaccines for adults. https://ja.ma/3VmhsQP

Romain Pirracchio of the University of California-San Francisco joins JAMA Deputy Editor Kristin Walter to discuss "Low-...
06/13/2024

Romain Pirracchio of the University of California-San Francisco joins JAMA Deputy Editor Kristin Walter to discuss "Low-Dose Corticosteroids for Critically Ill Adults With Severe Pulmonary Infections."

Severe pulmonary infections are a leading cause of death in adults worldwide. Romain Pirracchio, MD, MPH, PhD, of the University of California-San Francisco, joins JAMA Deputy Editor Kristin L. Walter, MD, MS, to discuss Low-Dose Corticosteroids for Critically Ill Adults With Severe Pulmonary Infect...

Viewpoint investigates the poor quality of health care provided to Indigenous peoples incarcerated in US tribal jails an...
06/12/2024

Viewpoint investigates the poor quality of health care provided to Indigenous peoples incarcerated in US tribal jails and proposes solutions to address health disparities and strengthen tribal sovereignty.

This Viewpoint investigates the poor quality of health care provided to Indigenous peoples incarcerated in US tribal jails and proposes solutions to address health disparities and strengthen tribal sovereignty.

New JAMA Guide to Statistics and Methods article reviews test-negative study designs for evaluating vaccine effectivenes...
06/12/2024

New JAMA Guide to Statistics and Methods article reviews test-negative study designs for evaluating vaccine effectiveness.

This JAMA Guide to Statistics and Methods article explains the test-negative study design, an observational study design routinely used to estimate vaccine effectiveness, and examines its use in a study that estimated the performance of messenger RNA boosters against the Omicron variant.

06/12/2024

Joel Dulhunty and Jason Roberts, authors of BLING III trial, spoke with JAMA Deputy Editor Preeti Malani on how the results of the trial will inform patient care in the ICU.

Listen to the full podcast: https://ja.ma/3Vig6Xq

Read the accompanying Original investigation “Continuous vs Intermittent β-Lactam Antibiotic Infusions in Critically Ill Patients With Sepsis.”
https://ja.ma/3RnYY18

Treatment with low-dose corticosteroids is associated with decreased mortality for patients with severe COVID-19 infecti...
06/12/2024

Treatment with low-dose corticosteroids is associated with decreased mortality for patients with severe COVID-19 infection, severe community-acquired bacterial pneumonia, and moderate to severe Pneumocystis pneumonia (for patients with HIV). https://ja.ma/4cfgBZc

The USPSTF's new breast cancer screening recommendation is more closely aligned with other US breast cancer screening gu...
06/12/2024

The USPSTF's new breast cancer screening recommendation is more closely aligned with other US breast cancer screening guidelines than its previous statement. And yet, the USPSTF’s advice continues to spark debate. Read the JAMA Medical News story.

This Medical News story discusses new USPSTF recommendations about the timing of screening mammograms.

06/12/2024

Joel Dulhunty, Royal Brisbane and Women’s Hospital, and Jason Roberts, University of Queensland Centre for Clinical Research, join JAMA Deputy Editor Preeti Malani, to discuss the BLING trial that assessed continuous vs intermittent β-lactam antibiotic infusions in patients with sepsis or septic shock. https://ja.ma/4efiG9l

From the Editorial "Resolving the Dilemma on Continuous vs Intermittent β-Lactam Antibiotics in Sepsis": "BLING III is a...
06/12/2024

From the Editorial "Resolving the Dilemma on Continuous vs Intermittent β-Lactam Antibiotics in Sepsis": "BLING III is a beautiful and impressive example of true team science that accelerates progress in the field."

https://ja.ma/4bWFXev

Meta-analysis: Among adults in the ICU who had sepsis or septic shock, the use of prolonged β-lactam antibiotic infusion...
06/12/2024

Meta-analysis: Among adults in the ICU who had sepsis or septic shock, the use of prolonged β-lactam antibiotic infusions was associated with a reduced risk of 90-day mortality compared with intermittent infusions.



https://ja.ma/4aXQrcf

In critically ill patients with sepsis, continuous vs intermittent β-lactam antibiotic infusions did not significantly r...
06/12/2024

In critically ill patients with sepsis, continuous vs intermittent β-lactam antibiotic infusions did not significantly reduce 90-day mortality.

https://ja.ma/3VBWG15

JAMA Deputy Editor Mary McGrae McDermott summarizes the June 11 issue.
06/11/2024

JAMA Deputy Editor Mary McGrae McDermott summarizes the June 11 issue.

JAMA Patient Page, "Screening for Breast Cancer," helps clinicians address with patients the 2024 USPSTF breast cancer s...
06/11/2024

JAMA Patient Page, "Screening for Breast Cancer," helps clinicians address with patients the 2024 USPSTF breast cancer screening recommendations. https://ja.ma/4elHvAG

Modeling analysis commissioned by USPSTF suggests that biennial mammography screening starting at age 40 reduces breast ...
06/11/2024

Modeling analysis commissioned by USPSTF suggests that biennial mammography screening starting at age 40 reduces breast cancer mortality and increases life-years gained per mammogram.

This modeling study uses Cancer Intervention and Surveillance Modeling Network models and national data on breast cancer incidence, mammography performance, treatment effects, and other-cause mortality in US women without previous cancer diagnoses to estimate outcomes of various mammography...

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