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Sequence MD SequenceMD provides medical genetics services within community health systems to adults and families with rare conditions, unique, or unmet medical needs

When symptoms don’t align with a familiar diagnosis, finding answers may require a different kind of expertise.SIGN #5:...
10/13/2026

When symptoms don’t align with a familiar diagnosis, finding answers may require a different kind of expertise.

SIGN #5: AN UNUSUAL OR HARD-TO-DIAGNOSE CONDITION: Some conditions involve symptoms that cross several specialties or don’t follow the patterns doctors typically see. In these cases, a specialist with experience in complex and rare conditions may offer a valuable perspective. For some patients, that specialist is a clinical geneticist.

Read more about when to seek a second opinion: https://sequencemd.com/when-is-it-time-to-get-a-second-opinion-about-your-symptoms/

Leaving the doctor’s office still uncertain about your health is a good reason to keep asking questions.SIGN #4: UNANSW...
10/13/2026

Leaving the doctor’s office still uncertain about your health is a good reason to keep asking questions.

SIGN #4: UNANSWERED QUESTIONS: You don’t need to doubt your diagnosis to want another doctor’s input. Maybe the cause of your symptoms is still a mystery, your test results don’t make sense to you or you’re not sure what options are on the table. Any of those items is enough to ask for more information or a second look.

Check out the five signs it might be time for a second opinion: https://sequencemd.com/when-is-it-time-to-get-a-second-opinion-about-your-symptoms/

Hearing a different theory from every specialist can make it harder to understand what’s going on.SIGN #3: VARYING EXPL...
10/09/2026

Hearing a different theory from every specialist can make it harder to understand what’s going on.

SIGN #3: VARYING EXPLANATIONS FROM SPECIALISTS: Each specialist tends to view symptoms through the lens of their own field. One may point to a particular condition, while another has a completely different idea. When those explanations don’t add up, a physician who reviews your full medical history may see how the pieces relate and bring the picture into focus.

See all five signs that a second opinion could help: https://sequencemd.com/when-is-it-time-to-get-a-second-opinion-about-your-symptoms/

Sticking with a treatment plan and still not feeling better can be a sign that something needs a closer look.SIGN #2: S...
10/08/2026

Sticking with a treatment plan and still not feeling better can be a sign that something needs a closer look.

SIGN #2: SYMPTOMS NOT RESPONDING TO TREATMENT: When you’re following your care plan as directed but symptoms hold steady or worsen, another evaluation may be the next move. A diagnosis is based on what’s known at the time. As new symptoms emerge, results come in or your condition changes, the picture can shift. A fresh review from another doctor may lead to rethinking the diagnosis, the treatment or both.

Explore the five signs it may be time for a second opinion: https://sequencemd.com/when-is-it-time-to-get-a-second-opinion-about-your-symptoms/

Ongoing symptoms with no clear cause often leave people wondering whether to seek another medical perspective.SIGN #1: ...
10/05/2026

Ongoing symptoms with no clear cause often leave people wondering whether to seek another medical perspective.

SIGN #1: SYMPTOMS WITHOUT AN EXPLANATION: When symptoms linger or get worse, and no one can pinpoint why, a second evaluation is a reasonable next step. Starting over with a new doctor after rounds of testing can feel discouraging. But a normal result doesn’t always mean everything is fine. Most tests check for specific conditions, so no single test can account for every possibility. Rare conditions may only show up through specialized testing or a different kind of evaluation.

Read about all five signs that could indicate it’s time for a second opinion: https://sequencemd.com/when-is-it-time-to-get-a-second-opinion-about-your-symptoms/

Normal test results should be reassuring. But when symptoms persist and no one can explain why, it’s reasonable to want ...
10/02/2026

Normal test results should be reassuring. But when symptoms persist and no one can explain why, it’s reasonable to want another set of eyes on your health.

Seeking a second opinion is part of getting the right care. It can be especially helpful when specialists don’t agree on a diagnosis, a condition showed up earlier or is progressing faster than expected, or symptoms don’t align with a common cause. A new provider will look closely at your history, symptoms and past results. That review may confirm you’re on the right track, uncover a different explanation or point to new testing, such as a genetic evaluation.

Our latest blog walks through what a second opinion involves and when to seek one: https://sequencemd.com/when-is-it-time-to-get-a-second-opinion-about-your-symptoms/

We’re welcoming Polly McGonigle to the SequenceMD team! Polly is a board-certified genetic counselor who brings both tec...
09/21/2026

We’re welcoming Polly McGonigle to the SequenceMD team! Polly is a board-certified genetic counselor who brings both technical depth and genuine care to her work. She earned her undergraduate degree in behavioral neuroscience from the University of San Diego and then completed her master’s in human genetics and genetic counseling at Keck Graduate Institute. She’s dedicated to helping patients make sense of complex diagnoses and feel supported at every step by pairing clinical expertise with a patient-centered approach. Polly grew up in Colorado and has returned, settling in Denver. Skiing, hiking, reading and painting are some of her favorite free-time activities. We’re very glad to have her on board.

The final red flag in our 10-part series: major malformations at birth.BORN WITH A BIRTH DEFECT: Birth defects often sig...
09/17/2026

The final red flag in our 10-part series: major malformations at birth.

BORN WITH A BIRTH DEFECT: Birth defects often signal broader genetic concerns. Through comprehensive testing and counseling, SequenceMD identifies related conditions and helps you manage them proactively to prevent complications down the road. Download the full red flags checklist: https://sequencemd.com/10-red-flags-you-may-have-a-genetic-disease/

You’re getting support for your disability, but other health concerns persist? Red flag #9 might explain why.DEVELOPMEN...
09/16/2026

You’re getting support for your disability, but other health concerns persist? Red flag #9 might explain why.

DEVELOPMENT DISABILITIES AND HIDDEN COMPLICATIONS: Whether you were born with a birth defect or developed intellectual or developmental disabilities, an underlying genetic disorder might be at work. Even with appropriate care in place, untreated genetic conditions can cause additional complications. SequenceMD testing reveals the full picture so you can address everything that needs attention. Learn more: https://sequencemd.com/10-red-flags-you-may-have-a-genetic-disease/

Recurrent miscarriages without answers is another red flag pointing you to genetic testing.TWO OR MORE PREGNANCY LOSSES:...
09/15/2026

Recurrent miscarriages without answers is another red flag pointing you to genetic testing.

TWO OR MORE PREGNANCY LOSSES: Multiple pregnancy losses, especially when unexplained, deserve investigation. Miscarriages are common, but a pattern of losses may point to an underlying genetic cause. SequenceMD genetic testing can identify what’s contributing to these losses and help you understand your options moving forward. Getting answers doesn’t just provide clarity. It can empower you to make informed decisions about future pregnancies and the care you need. Review all 10 red flags and download the checklist: https://sequencemd.com/10-red-flags-you-may-have-a-genetic-disease/

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1601 E 19th Avenue STE 4100
Denver, CO
80218

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+13038327109

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