Main Street Pharmacy

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Main Street Pharmacy Main Street Pharmacy is a locally owned and operated pharmacy in East Prairie, Missouri!

10/14/2026
💉 FREE FLU SHOTS AT MAIN STREET PHARMACY!💉Flu season is here — protect yourself and your family!✅ $0 with most insurance...
10/05/2026

💉 FREE FLU SHOTS AT MAIN STREET PHARMACY!💉

Flu season is here — protect yourself and your family!

✅ $0 with most insurance plans
🚗 Curbside flu shots available
⏰ No appointment necessary
⚡ Fast, easy & convenient!

Don’t want to get out of the car? Just pull up and give us a call — we’ll come to you!

📍 Main Street Pharmacy
📞 573-649-9229

Stop by and get your flu shot today! 💙

10/01/2026

DON’T LET A PHARMACY RUN SLOW DOWN YOUR FRIDAY!

Heading into the weekend? Let Main Street Pharmacy help you get your prescriptions taken care of quickly and conveniently.

💊 Fast, friendly service
🚗 FREE local delivery
📦 Convenient prescription packaging
🔄 Need to switch pharmacies? We’ll help with the transfer!
🎁 Plus, shop our gift selection while you’re here!

Skip the long lines and experience the difference of a locally owned hometown pharmacy.

📞 573-649-9229

MAIN STREET PHARMACY
Fast. Friendly. Local.

10/01/2026

TIRED OF FEELING LIKE JUST ANOTHER NUMBER?

At Main Street Pharmacy, we believe your pharmacy experience should be fast, friendly, and personal.

💊 Fast & friendly prescription service
📦 Convenient prescription packaging
🚗 FREE local delivery
🔄 Easy prescription transfer help
😊 A local team that’s here when you need us

Ready for a better pharmacy experience?

Give us a call at 573-649-9229 and let us help make the switch easy!

MAIN STREET PHARMACY
Local people. Personal service. Hometown care.

09/30/2026

MORE THAN JUST A PHARMACY!

Need a quick gift without making a trip out of town? Stop by Main Street Pharmacy and check out our gift shop!

🎁 Gifts for all occasions
🌸 Fresh flowers & arrangements from Main St Floral Co.
🛍️ Great last-minute gift options
💳 Something for a variety of budgets

Whether you need a birthday gift, something to brighten someone’s day, or just a little something for yourself, shop local and shop Main Street!

And while you’re here, we can take care of your prescriptions too.

Main Street Pharmacy
📞 573-649-9229
Your hometown pharmacy & gift shop

09/29/2026

READY FOR A PHARMACY THAT MAKES THINGS EASY?

Switching to Main Street Pharmacy is simple — just give us a call and we’ll help with the transfer!

💊 Fast, friendly service
🚗 FREE local delivery
📦 Convenient prescription packaging
🔄 Easy prescription transfers
🏠 Local service from people who know you

Spend less time waiting on prescriptions and more time doing what matters.

Call 573-649-9229 to make the switch!

MAIN STREET PHARMACY
Fast. Friendly. Local.

09/28/2026

⛽ GAS PRICES GOT YOU DOWN?

Let us bring your prescriptions to you — FOR FREE!

🚗 FREE LOCAL DELIVERY
💊 From our pharmacy straight to your door
🔄 Need to transfer your prescriptions? We can help!

Switching to Main Street Pharmacy is easy. Give us a call and we’ll help take care of the prescription transfer process.

📞 573-649-9229

Fast. Friendly. Local. Delivered FREE.

MAIN STREET PHARMACY
Your hometown pharmacy, right at your doorstep.

Spectrum has informed us that our internet service is not expected to be restored until approximately 7:30 p.m. Unfortun...
08/05/2026

Spectrum has informed us that our internet service is not expected to be restored until approximately 7:30 p.m. Unfortunately, because our pharmacy systems rely on an internet connection to safely process prescriptions and access patient information, we are unable to continue operations.

As a result, Main Street Pharmacy will be closed for the remainder of the day.

We sincerely apologize for the inconvenience and appreciate your patience and understanding. We look forward to serving you again as soon as service is restored.

Tomorrow 7/22. Check the comments for sweet Millie’s sales pitch. She’s such a doll!
07/22/2026

Tomorrow 7/22. Check the comments for sweet Millie’s sales pitch. She’s such a doll!

At Main Street Pharmacy, we're combining the latest technology with hometown service to give you the best pharmacy exper...
07/17/2026

At Main Street Pharmacy, we're combining the latest technology with hometown service to give you the best pharmacy experience possible.

Our advanced prescription filling technology helps improve safety and accuracy, giving you confidence that your medications are filled correctly every time. But technology is only part of what sets us apart.

We also offer:
• Fast, friendly, personalized service
• Free prescription packaging to help you stay organized and never miss a dose
• FREE local delivery, bringing your medications right to your door
• A knowledgeable team that's always here to answer your questions

You don't have to sacrifice personal service for convenience—you can have both.

Experience the Main Street Pharmacy difference. Stop by, give us a call, or let us help you transfer your prescriptions today. We’re here to serve you.

-Bryan

Address

117 E Main Street
East Prairie, MO
63845

Opening Hours

Monday 8:30am - 5:30pm
Tuesday 8:30am - 5:30pm
Wednesday 8:30am - 5:30pm
Thursday 8:30am - 5:30pm
Friday 8:30am - 5:30pm

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