09/20/2026
Pranjal interviews Dr. Michael Treadway, a cognitive neuroscientist and clinical psychologist who leads the TREAD Lab, where he studies the brain mechanisms underlying motivation and depression. They discuss why depression can make it feel almost impossible to do things, even things you once enjoyed, and how scientists distinguish between losing pleasure and losing motivation. Dr. Treadway explains the role of dopamine and the brain’s reward circuitry, how researchers measure motivation in the laboratory, and why depression may have different biological causes in different people. They also discuss how chronic stress can alter the brain, what this might teach us about resilience, and what it could mean for the future of more personalized treatments for depression. Dr. Treadway shares advice for families supporting a child who seems unmotivated and explains why a sudden change in motivation may be an important sign to pay attention to.
YouTube: https://youtu.be/5A6q-tIRQZY?si=29sEljjUUKZWpR7Y
Spotify: https://open.spotify.com/episode/6n1wtcVlJvs5Qwkf3zUZtB?si=06898667d85a40da
Apple podcasts: https://podcasts.apple.com/us/podcast/dr-treadway-on-the-neuroscience-of/id1622512933?i=1000790669238