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The Neurogenesis Project Optimize and Enhance your Brain Function and Cognitive Capacity for a healthier, happier, and more productive life. Contact us for a consultation.

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Why does cannabis feel calming one night and terrifying the next?A new Northwestern study in Nature Communications found...
10/17/2026

Why does cannabis feel calming one night and terrifying the next?

A new Northwestern study in Nature Communications found that a cannabinoid weakened a natural brake on fear neurons in the amygdala, and that higher doses plus stress released that brake together. It was done in mice, but it gives a real biological explanation for a night that goes bad fast, with no blame attached.

Dr. Drew Edwards explains what it means for people who use cannabis and for anyone in recovery: https://www.neurogenesisproject.com/blog/cannabis-anxiety-central-amygdala-somatostatin-neurons

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Has cannabis ever made your anxiety worse instead of better?

Your brain is mostly fat. So why does almost no brain workup look at it?A new Nature study from EPFL mapped 539 chemical...
10/16/2026

Your brain is mostly fat. So why does almost no brain workup look at it?

A new Nature study from EPFL mapped 539 chemically distinct lipid zones in the mouse brain, and even white matter, which we were taught to think of as uniform, turned out to be remarkably varied. It was done in mice, so it is a reference and not a clinical test, but it changes the questions worth asking about slowed thinking and memory.

Dr. Orr breaks down what the atlas found and what it does and does not mean for you: https://neurogenesisproject.com/blog/brain-lipid-map-539-lipizones-nature-epfl

Have you ever been told your scans were normal while your thinking felt anything but? Tell us about it below.

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Which brain looks older on an MRI: someone with schizophrenia, or someone with years of alcohol and to***co addiction?A ...
10/15/2026

Which brain looks older on an MRI: someone with schizophrenia, or someone with years of alcohol and to***co addiction?

A new PLOS Medicine analysis of nearly 49,000 scans found addiction scored higher than both schizophrenia and bipolar disorder, behind only Alzheimer's disease and mild cognitive impairment. Dr. Drew Edwards explains what it shows and what it can't.

https://www.neurogenesisproject.com/blog/alcohol-to***co-brain-age-mri-plos-medicine

What would change about how we treat addiction if every patient got a brain scan on day one?

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Same tau on the scan, completely different outcomes. Why?A new Nature Neuroscience study from Washington University sugg...
09/30/2026

Same tau on the scan, completely different outcomes. Why?

A new Nature Neuroscience study from Washington University suggests part of the answer sits outside the brain. In mice, the T cells that cause neurodegeneration get switched on in the neck's lymph nodes first. Block that step and the brain was spared, even with the tangles still there.

It's early, and it's mice. But it's a good reason to ask whether anyone has looked at the inflammation, not just the tau.

https://www.neurogenesisproject.com/blog/alzheimers-lymph-node-t-cells-tau-neurodegeneration

If a family member had Alzheimer's, would you want your doctor checking inflammation markers too?

Why can one person enjoy a good meal and walk away, while another cannot walk away from he**in?A new Nature Neuroscience...
09/25/2026

Why can one person enjoy a good meal and walk away, while another cannot walk away from he**in?

A new Nature Neuroscience study offers an answer that is not about willpower. In mice, he**in and methamphetamine forced the mitochondria inside dopamine nerve endings to switch on an emergency energy supply. Food never triggered it. When researchers shut that switch off, the drugs lost most of their pull and natural pleasures were untouched.

Dr. Drew Edwards explains what this means for anyone in recovery, and why the exhaustion and flat feeling of the first year has a biological cause: https://neurogenesisproject.com/blog/mitochondrial-calcium-switch-drug-reward

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If a medication could dial down drug reward without dimming everything else in life, what would that change for the people you love?

What if the thing you call "your brain" is actually two organs that evolved separately and got packed into the same skul...
09/23/2026

What if the thing you call "your brain" is actually two organs that evolved separately and got packed into the same skull?

That is what a Stanford Medicine team reported in Nature Neuroscience on September 18. The forebrain and the brain stem come from two different progenitor cells that never overlap, and the same split shows up in animals whose last common ancestor with us lived 550 million years ago.

Here is why it matters for you. Almost every brain optimization product on the market targets the forebrain: focus, memory, executive function. Your sleep quality, your heart rate variability, your breathing, and your appetite are governed by the other organ entirely. Dr. Sean C. Orr walks through what that means for anyone whose thinking has slowed down.

https://www.neurogenesisproject.com/blog/brain-two-separate-organs-hindbrain

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Which one have you actually been taking care of?

What if the single most effective way to prevent an opioid overdose death costs less than $50 and fits in a coat pocket?...
09/18/2026

What if the single most effective way to prevent an opioid overdose death costs less than $50 and fits in a coat pocket?

A new CDC modeling study tested four prevention strategies against a projected rebound in overdose deaths. Keeping every patient in treatment for six months wasn't enough on its own. Linking every overdose survivor to medication within a day wasn't either.

Bystander naloxone was. Reaching just 14.2% of potentially fatal overdoses was enough to offset the entire increase. And in 2024, someone who could have intervened was already nearby in 44.1% of fatal overdoses.

Dr. Drew W. Edwards breaks down what the numbers mean and what to do about them:
https://www.neurogenesisproject.com/blog/bystander-naloxone-overdose-prevention-cdc-model

Created with AI assistance.

Do you know where the nearest naloxone is right now, and would you recognize an overdose if you saw one?

Can a brain scan tell you your brain is older than you are?UCLA researchers analysed resting-state MRI from 1,462 adults...
09/16/2026

Can a brain scan tell you your brain is older than you are?

UCLA researchers analysed resting-state MRI from 1,462 adults and built what they call a Brain Aging Index, the gap between the age a model estimates from your brain's communication patterns and your actual age. Adults with a higher index scored worse on working memory and executive function, and reported more low mood. In one group, the index also tracked with specific gut bacteria and metabolites.

It is not a test you can order yet. But the biology behind it, which is metabolic, inflammatory, and vascular, is something we measure today.

Created with AI assistance.

https://neurogenesisproject.com/blog/brain-aging-index-memory-mood-gut-microbiome

What would you actually do differently if you knew your brain was running five years ahead of you?

"He's not an alcoholic, just a weekend guy." A mother said that to our office about her 24-year-old son. A new Brown Uni...
09/11/2026

"He's not an alcoholic, just a weekend guy." A mother said that to our office about her 24-year-old son. A new Brown University trial gives a more precise answer than we had at the time.

Healthy adults averaging age 25, drinking heavily for less than two years, already showed five elevated chronic-disease biomarkers in their blood compared with light drinkers of the same age. Markers of blood vessel stress and metabolic strain, in people with no diagnosis at all.

Dr. Drew Edwards breaks down what the study found, what it cannot claim about the brain, and why the early window is the one to act in.

https://neurogenesisproject.com/blog/young-heavy-drinkers-chronic-disease-biomarkers

If your family has a "weekend guy," what would it take for him to get his blood checked?

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Can an old brain be made younger by a protein that fades as we age?A protein called TIMP2 is abundant in umbilical cord ...
09/05/2026

Can an old brain be made younger by a protein that fades as we age?

A protein called TIMP2 is abundant in umbilical cord blood and drops off with age. In aged mice, giving it back improved memory and calmed the brain's immune cells. It is also one of the molecules carried inside mesenchymal stem cell exosomes.

Here is the part most stories skip: the strong evidence is still in mice, no human trial of TIMP2 for cognition has been done, and we do not claim stem cells or exosomes treat or cure any disease. Dr. Sean C. Orr, M.D. lays out what the science actually supports and what it does not.

https://neurogenesisproject.com/blog/timp2-youth-protein-brain-aging

What would you want proven before trying something like this?

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