Lima Naturopathic

10/12/2026

SPMs, Immune Balance, and Autoimmune Disease⬇️

The journal Science Bulletin has recently published a review of research on specialized pro-resolving lipid mediators (SPMs) and autoimmune disease. As discussed in this review, sustained leukocyte activation is central to many autoimmune diseases, and while both specific and nonspecific immunosuppressants relieve symptoms by supporting a healthy inflammatory response, a wide range of side effects underscores the need for better therapies. A growing understanding of the important differences between the natural inhibition and resolution of inflammation has sparked significant interest in the potential SPMs offer with autoimmune conditions.

Briefly, SPMs are compounds derived from omega-6 and omega-3 fatty acids, including resolvins, protectins, and maresins (metabolites of DHA/EPA), as well as lipoxins and aspirin-derived lipoxins (metabolites of arachidonic acid), requiring metabolic steps catalyzed by lipoxygenases, cyclooxygenase-2, and other enzymes. Much of the action of SPMs is mediated by G protein-coupled receptors found on immune cells (leukocytes, macrophages, neutrophils, etc.), though they do interact with other receptor types, such as the aryl hydrocarbon receptor, cannabinoid receptor 1, and transient receptor potential channels, with many downstream effects on both innate and adaptive immune responses. This includes helping to lower proinflammatory cytokine secretion by dendritic cells, enhancing macrophage phagocytosis and autophagy, as well as promoting polarization to the M2 macrophage anti-inflammatory phenotype, regulating B cell hyperactivation, modulating Th1/Th17 and Treg equilibrium, and much more, with the cumulative effect of restoring homeostasis by actively promoting the natural resolution of inflammation. This recognition that inflammation resolves via an active process rather than a passive one is the breakthrough understanding that makes SPMs so promising.

The review in Science Bulletin provides a detailed discussion of common autoimmune conditions, including rheumatoid arthritis, multiple sclerosis, type 1 diabetes mellitus, etc., as well as animal models and human studies investigating the role of SPMs in these conditions. To date, most human studies have not been intervention trials but rather assessments of the potential use of SPMs as biomarkers in autoimmune diseases. For example, a small study found significantly lower levels of Resolvin D1 (RvD1) in people with systemic lupus erythematosus (SLE), suggesting a possible threshold with 80% sensitivity and 63.3% specificity for identifying SLE. Lower levels of RvD1 have also been found among people with Hashimoto’s thyroiditis, with an inverse correlation with anti-thyroid peroxidase antibody (TPOAb) titers, with similar findings for Resolvin E1 (RVE1) and anti-thyroglobulin antibodies (TgAb). RvD1 levels were also found to be decreased among people with neuromyelitis optica spectrum disorders (NMOSD) and negatively correlated with aquaporin-4 (AQP4) antibody titers, while leukotriene B4 (LTB4) levels were increased in cerebrospinal fluid.

Preclinical and experimental models suggest SPMs may be novel therapies for various autoimmune conditions, though human clinical trials demonstrating efficacy, determining dosage and administration, optimal SPM combinations, etc., are still lacking. However, their role as immunomodulators (rather than immunosuppressants) that promote the resolution of pathological compromised inflammatory responses makes SPMs distinct from existing therapies.

➡️ How exciting is this? Lima Naturopathic has its own Foundational Cellular Response Complex, providing SPM precursors—the building blocks used by the body to make specialized pro-resolving mediators!

Our LN Clinical Formulas formula delivers 500 μg of SPM precursors per serving, alongside omega-3 fatty acids, to support the body’s natural inflammation-resolution pathways.*

Designed to support:

• Joint and muscular comfort*
• Healthy tissue repair*
• A balanced immune and inflammatory response*

Available at Lima Naturopathic.

Get yours today⬇️

https://www.limanaturopathic.com/product-page/ila-clinical-formulas-lima-naturopathic-foundational-cellular-response-complex

The research above explores SPMs; it did not evaluate this formula, which provides SPM precursors.

LN Clinical Formulas Foundational Cellular Response Complex Delivers an industry-leading 500 μg per serving of Pro-Resolving Mediator (SPM) precursors—targeted omega-3 metabolites that act as essential building blocks for the body’s natural production of Specialized Pro-Resolving Mediators. For...

10/12/2026

🚨 COLUMBUS DAY FLASH SALE! 🚨
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For just $400, your Lima Naturopathic package includes:

✨ Hair, nail, urine & saliva bioenergetics feedback test
✨ One-hour initial appointment
✨ One-hour follow-up appointment

What is bioenergetic feedback?
A non-diagnostic wellness tool that explores over 40,000 potential areas of imbalance from a bioenergetic perspective. I use this feedback alongside your health history and wellness goals to help guide a more focused, individualized approach. Consultations explore nutritional support—including vitamins, minerals, fatty acids, and amino acids—as well as hormonal wellness, detox support, organ and gland support, food and environmental concerns, and genetic-related wellness topics. In my practice, I’ve found this feedback valuable in organizing personalized recommendations and helping clients navigate their wellness options with clearer direction.

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10/09/2026

A cabinet full of supplements and medications… every diet under the sun… and you STILL don’t feel like yourself⁉️

You’ve researched. Bought the vitamins. Bought the supplements. Tried the latest wellness trends.

You’ve searched for ways to ease inflammation and pain, clear the brain fog, and make sense of those mysterious issues that keep leaving you frustrated.

You’ve bought and tried what worked for someone else—but you’re still not seeing the results you hoped for. And you’re still looking for direction.

You don’t have to keep figuring it all out on your own.

What works for one person may not be the right fit for YOUR body, YOUR history, or YOUR goals. Professional guidance can help you make informed choices about your wellness.

At Lima Naturopathic, we take time to listen, discuss your concerns, and help you build an individualized approach to nutrition, supplements, and daily habits.

New season. New direction. Put YOUR health on the calendar this fall.

Your personalized wellness package: $595 for TWO appointments + HNUS bioenergetic testing.

Your package includes:

• An in-depth initial consultation: We take time to explore your health history, current concerns, individual needs, and wellness goals, along with an initial wellness analysis. I listen, ask questions, and get to know what you’ve been experiencing so we can discuss your wellness needs in detail.

• HNUS bioenergetic testing: Included as part of your wellness package.

• An in-depth second appointment: Once your testing is complete, we meet to review and discuss the results, answer your questions, and put together your individualized wellness plan.

If you’ve been thinking about working with me, call our office or book online today!

10/02/2026

ANDROGRAPHIS AND CANCER
One plant compound. Multiple anti-cancer properties❗️❗️❗️

What caught my attention wasn’t just one finding. It was the range of cancer-related processes being studied—from triggering cancer-cell death to interfering with tumor blood-vessel formation and growth signals.

As I reviewed the studies on andrographolide, a major active compound in Andrographis paniculata, I found research involving breast cancer, leukemia, colorectal cancer, prostate cancer, liver cancer, and lymphoma, along with early human research in esophageal cancer.

Here are the findings that stood out to me.

➜ BREAST CANCER: INHIBITING TUMOR GROWTH❗

In one mouse study, isolated andrographolide produced 60.2% tumor-growth inhibition compared with controls at the highest dose tested. That measures inhibited growth relative to controls—not a 60.2% shrinkage of existing tumors.

➜ LEUKEMIA: DISRUPTING CELL-SURVIVAL PROCESSES❗

Laboratory studies have found effects on programmed cell death, fatty-acid production, iron uptake, and growth-related signaling. A 2025 T-cell leukemia study reported evidence of both apoptosis and ferroptosis—two different forms of cell death. Other work observed differentiation, or maturation, in acute promyelocytic leukemia cells.

➜ COLORECTAL CANCER: EXPLORING TREATMENT RESISTANCE AND IMMUNE ACTIVITY❗

In cells, mice, and miniature tumor models grown from patient tissue, andrographis enhanced the effects of the chemotherapy drug 5-FU. Separate mouse research found that andrographolide activated an immune danger-sensing pathway and increased several immune-cell populations within tumors.

➜ PROSTATE CANCER: INTERFERING WITH INFLAMMATORY GROWTH SIGNALS❗

Andrographolide reduced IL-6 and related signaling, inhibited cancer-cell growth, and activated programmed cell death in experimental models, including castration-resistant prostate cancer. Reduced tumor growth was also observed in mice.

➜ LIVER CANCER: INTERFERING WITH TUMOR BLOOD-VESSEL FORMATION❗

Laboratory and mouse experiments found that andrographolide disrupted VEGF-related signaling, reduced blood-vessel formation, and inhibited tumor growth.

➜ LYMPHOMA: ACTIVATING CANCER-CELL SELF-DESTRUCTION❗

Andrographolide triggered programmed cell death in lymphoma cell lines and cancer cells collected from patients. Normal lymphocytes were comparatively spared under the conditions tested.

➜ ESOPHAGEAL CANCER: EARLY HUMAN RESEARCH❗

A small study involving 30 people with advanced esophageal cancer reported longer survival among those who completed andrographis treatment. However, comparing people who completed treatment with those who did not cannot establish that the herb caused the survival difference.

What stands out is the range of processes being studied: cancer-cell death, growth signaling, tumor blood supply, immune activity, and treatment resistance.

I’ll share the studies in the comments for anyone who wants to explore the research.

Lima Naturopathic

09/22/2026

MIGRAINES?

Do you—or does someone you know—suffer from migraines?

What if I told you that, in a clinical trial, GINGER performed just as well as a prescription migraine medication?

I’ve even had A LIST of clients tell me that ginger worked BETTER for them personally.

Yes—ginger. 🫚

In a randomized clinical trial involving 100 people with migraines, researchers compared 250 mg of ginger with 50 mg of sumatriptan, a commonly prescribed migraine medication.

After two hours, both groups experienced a similar reduction in migraine severity—but side effects were reported less frequently in the ginger group.

Ginger contains powerful natural compounds called gingerols and shogaols, which may influence inflammation, prostaglandins, pain signaling, nausea, and other pathways involved in a migraine attack.

Additional clinical research has also found that ginger may improve migraine pain within two hours while helping reduce migraine-related nausea and vomiting. ⬇️🫚⬇️🫚⬇️🫚

09/14/2026

ALL PROTEIN POWDERS ARE NOT CREATED EQUAL.

When tolerated, whey protein is my first choice—and it’s about far more than simply increasing protein intake.

Whey is a rapidly digested, complete protein containing all nine essential amino acids. It produces a faster rise in circulating amino acids, making these essential building blocks available quickly to muscles and other tissues—including those supporting the nervous system.

Gram for gram, whey generally supplies a higher concentration of essential amino acids than most individual plant proteins—especially the amino acids needed for muscle growth, recovery, repair, and maintenance. Whey is also naturally rich in leucine, a critical signal for stimulating muscle protein synthesis.

And don’t confuse rapid amino-acid absorption with everything simply “passing right through.” Those are two different processes. Preclinical research found that whey slowed small-intestinal transit compared with plant protein, suggesting it may provide more intestinal contact time—even while its amino acids are absorbed rapidly. Whey-based and hydrolyzed-whey formulas have also been used therapeutically in clinical nutrition when easy digestion, absorption, and nutritional support are especially important.

Whey also supplies cysteine and naturally occurring bioactive components that have been studied for their roles in glutathione production, nutritional status, and immune support.

When whey is tolerated, it remains my first choice. It isn’t just protein—it’s functional, therapeutic nutrition.

09/14/2026

Your microbiome doesn’t just equal your gut health—it’s so much more.

Your microbiome influences your brain and neurological health, hormones, immune response, inflammation, metabolism, and so much more.

When the microbiome is out of balance, the effects may show up far beyond digestion.

The microbiome isn’t just connected to your digestion—it’s connected to nearly every aspect of your health. 🦠✨

09/14/2026

No, Ma’am. No, Sir. You Didn’t Already Try It.

I hate to come across as rude, but I need to say this.

I have people come into my office, pay for my professional guidance, and then argue with nearly everything I recommend. I often give clients far more time than they are paying for because that is the kind of person I am. I genuinely care, and I put a tremendous amount of time, research, education, and thought into every individualized protocol.

Many new clients arrive carrying bags—sometimes literal bags—of supplements they have purchased online, researched themselves, or received from another practitioner.

First of all, if you are taking a bucket full of supplements and have been told you need to remain on all of them forever, that is not my idea of a successful wellness plan. Run from that approach.

But that is not even my main point.

People come into my office taking all these products because they still do not feel well. If everything in that bag were accomplishing what they needed, they probably would not be sitting in front of me asking what to change.

Then I recommend a different protocol—sometimes using products I have spent considerable time researching or helping design—and the response is:

“Oh, I already tried that.”

No, ma’am. No, sir. You didn’t try it.

You recognize one or two similar ingredients on the label. That does not make it the same formula, the same combination, the same protocol, or the same recommendation.

Taking an isolated B12 or folate is not the same as using a comprehensive methylation formula. Methylation is an interconnected process that may involve B12, 5-MTHF, B6, riboflavin, choline, amino acids, minerals, and other cofactors. Depending on the individual, a broader protocol may also include support for digestion, elimination, lymphatic flow, and normal liver function.

Taking one form of magnesium is not the same as taking a thoughtfully designed mineral complex. One mineral does not automatically supply everything the body needs for proper mineral balance.

The form matters.
The dosage matters.
The combination matters.
The ratios matter.
The companion ingredients matter.
The cofactors matter.
Your digestion and absorption matter.
Your individual biochemistry matters.

Swallowing a nutrient does not automatically mean your body is effectively absorbing, activating, balancing, and utilizing it.

And quality is not the only issue.

There are plenty of clean, organic, food-based, beautifully packaged supplement companies. But let me put this as nicely as I can:

Some of their formulas SUCK! 😬

A company can use clean, high-quality ingredients and still create an incomplete or completely ordinary formula. Many products lack the complementary ingredients and cofactors needed to support how the main ingredients function within the body. There may be absolutely nothing special about that expensive bottle beyond attractive marketing.

My recommendations are informed by nutritional science, biochemical pathways, my education in natural medicine, years of experience, individual priorities, and relevant genetic information when it is available. I look at the complete formula—not one impressive ingredient printed on the front.

You are always free to accept or decline my recommendations. But why waste your money—and my time—paying for an individualized plan if you have already decided that everything in your supplement bag is equivalent to what I am recommending?

It isn’t.

And no, my goal is not to keep clients taking a bucket of supplements forever. Recommendations may be used for a specific period and reassessed as priorities change. Ideally, the plan becomes simpler over time, with only a few foundational products continued when appropriate.

I want to identify and support the underlying areas creating the greatest burden—not cover everything up with a lifetime collection of pills.

So, no, ma’am. No, sir.

You didn’t already try what I am recommending. You tried something different—and I am recommending something different for a reason.

09/14/2026

Not Everyone Needs a Parasite Cleanse

Parasite cleanses are extremely trendy right now, and I receive calls about them all the time. But the truth is, parasites are not the priority for everyone—and if they are not showing up as a priority, why would we focus all of our energy there?

The body is complex. Parasites, bacteria, fungus, chemicals, heavy metals, poor elimination, nutritional deficiencies, and methylation challenges can overlap and influence the body’s internal terrain. This is why I do not believe in blindly choosing one “parasite pill” and expecting it to address the whole picture.

A well-designed naturopathic detox approach should look beyond one trendy target. It should support the whole body—including digestion, methylation, healthy elimination, lymphatic movement, and the organs involved in the body’s natural detoxification processes—while addressing the individual’s actual priorities.

At Lima Naturopathic, our Qest4 bioenergetic testing helps us identify which areas the body is prioritizing for wellness support. Instead of guessing that everyone needs the same parasite cleanse, we create an individualized plan based on what your body is showing us.

Detox should never be one-size-fits-all. Address the priority, support the whole body, and stop chasing every new wellness trend.

08/31/2026

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