American Association of Neuropathologists

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American Association of Neuropathologists Professional society of composed of physicians and scientists involved in research, training, and the clinical practice of neuropathology.

The American Association of Neuropathologists, Inc., is a professional society of neuropathologists, composed of physicians and scientists involved in research, training, and the clinical practice of neuropathology. Our Goals

The American Association of Neuropathologists seeks:

to disseminate knowledge about disorders affecting the nervous system through publications, lectures, courses, and all other forms of communication,
to create new knowledge through scientific research and publication, joining teams of other scientists, scholars, and physicians in a team-based approach to discovery, and
to educate and mentor young physicians and scientists who have chosen, or are contemplating joining us in our mission to eradicate neurologic disease and the associated disability.

⭐️AANP Case of the Month⭐️Author: Dr. Dimitri Trembath (Foundation Medicine)55F w/ dural mass.  Histology and copy numbe...
10/09/2026

⭐️AANP Case of the Month⭐️
Author: Dr. Dimitri Trembath (Foundation Medicine)
55F w/ dural mass. Histology and copy number plot are shown. DDx? WHO grade based on histology? What does the CNV plot tell you about this tumor’s behavior and grade? What IHC can serve as a surrogate for the key molecular finding?

👉AANP Teaching Rounds👈The next session will occur on Wednesday October 28th, with Sandra Carmelo-Piragua, MD. Visit http...
10/06/2026

👉AANP Teaching Rounds👈

The next session will occur on Wednesday October 28th, with Sandra Carmelo-Piragua, MD. Visit https://www.neuropath.org/teaching-rounds for more information & to register.

Please Note: There is a delay between registering for the activity and receiving access to the series in Path LMS, the learning management system. You must be registered prior to 4:00 PM Mountain Time the day before a session in order for access to be guaranteed.

⭐️AANP Case of the Month⭐️Authors: Drs. Danielle Lombardo, Doug Anthony, & Mike Punsoni (Brown University)Clinical Histo...
09/28/2026

⭐️AANP Case of the Month⭐️
Authors: Drs. Danielle Lombardo, Doug Anthony, & Mike Punsoni (Brown University)
Clinical History: A 76 M has been followed by his ophthalmologist for worsening diplopia, exotropia, ptosis, and retinitis pigmentosa. The DDx was chronic progressive external ophthalmoplegia (CPEO), other mitochondrial disorder or amyloidosis. During orbital surgery for strabismus (to reduce diplopia) a biopsy of the medial re**us muscle was performed to assess mitochondrial structure and assess for the possibility of amyloid deposition.

Re resection for treated Glioblastoma.  The “punched out” lesions from XRT may initially mimic necrosis with pseudo pall...
09/16/2026

Re resection for treated Glioblastoma. The “punched out” lesions from XRT may initially mimic necrosis with pseudo pallisading; however Olig-2 reveals most glial cells are small, round, and bland (non-neoplastic). Ki-67 is low, with many positive cells being inflammatory in nature.

Angiocentric glioma, WHO grade 1.  Note the impressive number of bipolar spindle cells concentrated around vessels.  A M...
08/27/2026

Angiocentric glioma, WHO grade 1. Note the impressive number of bipolar spindle cells concentrated around vessels. A MYB::QKI fusion was detected.



⭐️ AANP Case of the Month⭐️Authors:  Drs. Peter Kobalka & Krishna Bharani 30yo male hx insidious ataxia and HAs who pres...
08/06/2026

⭐️ AANP Case of the Month⭐️
Authors: Drs. Peter Kobalka & Krishna Bharani
30yo male hx insidious ataxia and HAs who presented to the ED with acute severe worsening HA and N/V.
MRI large, enhancing cerebellar intraparenchymal mass.
DDx? Which IHC stains will help? What is your final diagnosis?


⭐️ AANP Case of the Month ⭐️ Credit: Drs. Hannah E. Xavier & Kathryn P. ScherpelzUniversity of Washington30M hx hx granu...
07/21/2026

⭐️ AANP Case of the Month ⭐️
Credit: Drs. Hannah E. Xavier & Kathryn P. Scherpelz
University of Washington
30M hx hx granulomatous inflammation of te**es now with episodes of aphasia, HA, vertigo. MRI foci PV enhancement left frontal encephalomalacia/gliosis. Blood products in both frontal lobes and cerebellum. Bx (below) showed granulomatous meningitis. ANCA neg. He died at age 40 from interstitial lung dz.

64M multiple ring-enhancing masses thought to be Mets.  DDx? What can you tell me about pts hx?  What stain is this?    ...
07/01/2026

64M multiple ring-enhancing masses thought to be Mets. DDx? What can you tell me about pts hx? What stain is this?

⭐️ AANP Teaching Rounds ⭐️ The next session will occur on Monday, July 27 with CJ Lucas, MD.  Visit www.neuropath.org/te...
07/01/2026

⭐️ AANP Teaching Rounds ⭐️

The next session will occur on Monday, July 27 with CJ Lucas, MD. Visit www.neuropath.org/teaching-rounds for more information.

Please Note: There is a delay between registering for the activity and receiving access to the series in Path LMS, the learning management system. You must be registered prior to 4:00 PM Mountain Time the day before a session in order for access to be guaranteed.

06/03/2026

⭐️AANP Case of the Month⭐️
Credit: Drs. Maryam Abdo & Nelli S Lakis

62M with intractable seizures. MRI calcified mass in centrum semiovale. Histology shown. DDx? What is standard treatment?

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