CBD Plus Gold

09/29/2026

Come join our Cookeville team! We are looking for a Sales Associate to join our ranks. We are having open interviews 10/02 - 10/03 from 11am - 6pm. Bring a resume and a positive attitude! See you there!

09/28/2026

21+ Only. Need alternatives? Visit C*D Plus Gold and wake up refreshed tomorrow 😉.

09/26/2026

Stop in for weekend supplies!!! Discounts and freebies daily!

09/14/2026

What is a COA? Learn more about what a certificate of analysis is, and how you can double check what is in your h**p products.

09/10/2026

21+ only Willie’s lands today! Fully compliant and fully stocked with all your favorites!

09/10/2026

Willie’s lands today! Fully stocked with all your favorites!

09/02/2026

Stop in for your favorites and updates on the latest news. BOGO 25% Off through Monday!

09/01/2026

Today is the last day of our in-store deals and pricing! Check them out today at a C*D Plus near you.

08/12/2026

Stop in and see us for Buy One Get One 25% Off!

08/12/2026

Throughout the years we have heard from countless customers about their positive experiences with C*D Plus. Come in today and share yours at a C*D Plus near you.

FDA DISCLAIMER: The statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease. All information p...

08/12/2026

Throughout the years we have heard from countless customers about their positive experiences with C*D Plus. Come in today and share yours at a C*D Plus near you.

08/05/2026

08/05/2026

https://www.facebook.com/share/19Xc8MrXwv/?mibextid=wwXIfr

As a 5x Cancer Survivor, inflammation has never felt like a side issue to me. It’s been the spark behind pain, disease progression, immune confusion, and long before cancer shows up on a scan, it’s often inflammation doing the quiet damage. When the ECS, our Master Regulator, is balanced, inflammation has less room to run wild. That’s why this paper matters, and why acidic cannabinoids deserve far more respect than they’ve been given.
Therapeutic potential of acidic cannabinoids: an update (2026) makes something very clear - the acidic forms of cannabinoids are not inactive placeholders waiting to be heated. They are biologically active molecules with distinct anti-inflammatory mechanisms that differ substantially from those of their neutral counterparts.
The review highlights C*DA, THCA, and CBGA as compounds with direct relevance to inflammation control. C*DA stands out for its selective inhibition of COX-2, one of the primary enzymes driving prostaglandin mediated inflammation. That places C*DA in the same conversation as common anti-inflammatory drugs, but through plant-based regulation of inflammation via the ECS-linked pathway rather than by blunt enzyme suppression.
THCA is given similar weight. The authors describe THCA’s anti inflammatory effects as being linked to PPARγ activation, a nuclear receptor that regulates inflammatory gene expression, immune tone, and metabolic balance. This is not surface-level symptom relief. PPARγ signaling sits upstream, influencing how immune cells behave before inflammation spirals out of control.
One of the most important points in this review is how acidic cannabinoids can calm inflammation before cytokines flood the system. The paper explains that these compounds can inhibit store-operated calcium entry (SOCE), a key process in immune cell activation. By reducing calcium-driven overactivation, acidic cannabinoids may suppress excessive inflammatory signaling at its source rather than merely dampening ECS-connected prostaglandin-mediated effects in the aftermath.
The review also discusses THCA in inflammatory arthritis models, where it reduced joint swelling, inflammatory biomarkers, synovial hyperplasia, and cartilage damage. Again, the proposed mechanisms involve PPARγ signaling and peripheral ECS activity, reinforcing the notion that these compounds act through regulation rather thananti-inflammatory intoxication.
The authors are honest about limitations. Acidic cannabinoids are chemically unstable, easily decarboxylated by heat and light, and often have low oral bioavailability. These challenges explain why clinical adoption has lagged, not because the biology is weak, but because formulation and delivery have not kept pace with the science.
This is where lived experience and research finally meet. Patients have long used raw and minimally processed extracts to manage inflammation, immune imbalance, and chronic conditions. Therapeutic potential of acidic cannabinoids: an update (2026) doesn’t oversell the story, but it confirms what many of us already know - the acid forms matter, especially when inflammation is the real enemy.
Inflammation is not just a symptom. It’s a driver. Acidic cannabinoids speak directly to that driver through COX-2, PPARγ, calcium signaling, and immune regulation. This isn’t fringe science anymore.
It’s a research-backed reminder that balance at the System level is where real healing starts. Reach out if you need help or advice.
-Mike Robinson, Founder, Global Cannabinoid Research Center

07/21/2026

We know there have been a lot of questions raised over the new Tennessee law change. We hope this post can help answer some of those questions! We want to try and be as open and transparent as possible about our customers.

07/14/2026

C*DPLUS CUSTOMERS:

Several of our locations have recently acquired their license to sell your favorite cannabis products here in TN.
If you do not see your store, don't worry! More locations will receive their license soon. We will post when they do so stay tuned!

Current C*DPlus Stores:
234 E Main St, Sevierville, TN 37862
612 Lyle St #115,Johnson City, TN 37604
109 Moss Grove Blvd Ste 109,Knoxville, TN 37922
7200 Shallowford Rd Ste 111 & 112,Chattanooga, TN 37421
4329 W Andrew Johnson Hwy #3,Morristown, TN 37814
1001 E Stone Dr I,Kingsport, TN 37660

If your store is not listed,don’t panic! More of our stores will receive their license soon. Make sure to follow us as we will post updates soon.

02/13/2026

💘 FREE LOVE! 💘
The final day of our Week of Love is tomorrow - and this is your last chance to feel it.
Don’t miss the deals. Don’t miss the vibes.
Spread the Free Love! 💞

*DPlusUSA

02/12/2026

💝 Bundles of Love are here.
Day 5 of our Week of Love is all about more to love in every bundle.
Perfect for sharing, gifting, or treating yourself.

*DPlusUSA