UNMC Center for Heart and Vascular Research

UNMC Center for Heart and Vascular Research Our goal is to support and empower cardiovascular research efforts at UNMC that will bring new understanding and treatment options for patients with heart or vascular disease.

We appreciate your interest in the center and look forward to hearing from you.

Operating as usual

Ins2+/-/miR-133aTg, find out what it's all about in this study from the Mishra lab.https://pubmed.ncbi.nlm.nih.gov/33606...
03/08/2021
Generating Ins2 +/-/miR-133aTg Mice to Model miRNA-Driven Cardioprotection of Human Diabetic Heart - PubMed

Ins2+/-/miR-133aTg, find out what it's all about in this study from the Mishra lab.
https://pubmed.ncbi.nlm.nih.gov/33606210/

Diabetes mellitus (DM) is caused either due to insulin deficiency (T1DM) or insulin resistance (T2DM). DM increases the risk of heart failure by diabetic cardiomyopathy (DMCM), a cardiac muscle disorder that leads to a progressive decline in diastolic function, and ultimately systolic dysfunction. M...

To learn more about mouse models of glaucoma. Follow the link.https://pubmed.ncbi.nlm.nih.gov/33584206/
02/22/2021
Neuronal and Synaptic Plasticity in the Visual Thalamus in Mouse Models of Glaucoma - PubMed

To learn more about mouse models of glaucoma. Follow the link.
https://pubmed.ncbi.nlm.nih.gov/33584206/

Homeostatic plasticity plays important role in regulating synaptic and intrinsic neuronal function to stabilize output following perturbations to circuit activity. In glaucoma, a neurodegenerative disease of the visual system commonly associated with elevated intraocular pressure (IOP), the early di...

Congratulations to Yiannis Chatzizisis, MD, PhD, section chief of interventional cardiology, Gregory Pavlides, MD, PhD, ...
02/16/2021
Nebraska Medicine first in nation to use specialized stent

Congratulations to Yiannis Chatzizisis, MD, PhD, section chief of interventional cardiology, Gregory Pavlides, MD, PhD, and Edward O'Leary, MD -- implanted the SYNERGY MEGATRON stent for the first time ever in the United States. Both are faculty members in the in the UNMC Division of Cardiovascular Medicine and members of CHVR. Well done team!

Follow this link to read full article: https://www.unmc.edu/news.cfm?match=26914

SYNERGY MEGATRON BP-DES a 'game changer' for interventional cardiology.

What induces cellular senescence of hepatic endothelium in obesity? click the link to find out.  https://pubmed.ncbi.nlm...
02/15/2021
Long non-coding RNA Meg3 deficiency impairs glucose homeostasis and insulin signaling by inducing cellular senescence of hepatic endothelium in obesity - PubMed

What induces cellular senescence of hepatic endothelium in obesity? click the link to find out.

https://pubmed.ncbi.nlm.nih.gov/33508742/

Obesity-induced insulin resistance is a risk factor for diabetes and cardiovascular disease. However, the mechanisms underlying endothelial senescence in obesity, and how it impacts obesity-induced insulin resistance remain incompletely understood. In this study, transcriptome analysis revealed that...

Does this assessment improve quality of streptavidin-based enrichment studies? Follow the link to find out. https://pubm...
02/01/2021
Assessment of Streptavidin Bead Binding Capacity to Improve Quality of Streptavidin-based Enrichment Studies - PubMed

Does this assessment improve quality of streptavidin-based enrichment studies? Follow the link to find out. https://pubmed.ncbi.nlm.nih.gov/33270449/

The streptavidin-based enrichment of biotin-tagged molecules is a common methodology that is routinely used across multiple disciplines in biomedical research. Numerous and varied formats of immobilized streptavidin and related proteins are available, but predicting which product is most apt for a g...

What prevents acute hypotensive response? Read this article to find out. https://pubmed.ncbi.nlm.nih.gov/32863236/
01/25/2021
Nanoformulation of the superoxide dismutase mimic, MnTnBuOE-2-PyP 5+, prevents its acute hypotensive response - PubMed

What prevents acute hypotensive response? Read this article to find out.
https://pubmed.ncbi.nlm.nih.gov/32863236/

Scavenging superoxide (O2•-) via overexpression of superoxide dismutase (SOD) or administration of SOD mimics improves outcomes in multiple experimental models of human disease including cardiovascular disease, neurodegeneration, and cancer. While few SOD mimics have transiti...

Check out this article to see what the Case lab has been up to. https://pubmed.ncbi.nlm.nih.gov/32890698/
01/04/2021
Peripheral inflammation is strongly linked to elevated zero maze behavior in repeated social defeat stress - PubMed

Check out this article to see what the Case lab has been up to.
https://pubmed.ncbi.nlm.nih.gov/32890698/

Post-traumatic stress disorder (PTSD) is a psychiatric illness that results in an increased risk for a variety of inflammatory diseases. The exact etiology of this increased risk is unknown, and thus several animal models have been developed to investigate the neuroimmune interactions of PTSD. Repea...

Congrats CHVR members Alicia Schiller, Ioannis Chatzizisis, Hanjun Wang, Irving Zucker
12/16/2020
Dr. Irving H. Zucker on Twitter

Congrats CHVR members Alicia Schiller, Ioannis Chatzizisis, Hanjun Wang, Irving Zucker

“Team explores drug-free hypertension treatment | UNMC https://t.co/dqdJtNSjkU via @twitterapi This should bring new validation technology to renal denervation right in the cath lab.”

How does Inhibition of Pyk2 and Src activity improve Cx43 gap junction intercellular communication? Open the link to fin...
12/14/2020
Inhibition of Pyk2 and Src activity improves Cx43 gap junction intercellular communication - PubMed

How does Inhibition of Pyk2 and Src activity improve Cx43 gap junction intercellular communication? Open the link to find out.
https://pubmed.ncbi.nlm.nih.gov/32956670/

Identification of proteins that interact with Cx43 has been instrumental in the understanding of gap junction (GJ) regulation. An in vitro phosphorylation screen identified that Protein tyrosine kinase 2 beta (Pyk2) phosphorylated purified Cx43CT and this led us to characterize the impact of this ph...

Read this article to find out what increases autophagic flux in chronic heart failure. #patelhttps://pubmed.ncbi.nlm.nih...
11/23/2020
MMP9 inhibition increases autophagic flux in chronic heart failure - PubMed

Read this article to find out what increases autophagic flux in chronic heart failure. #patel
https://pubmed.ncbi.nlm.nih.gov/33064567/

An increased matrix metalloprotease9 (MMP9) during post-myocardial infarction (post-MI) exacerbates ischemia-induced chronic heart failure (CHF). Autophagy is cardioprotective during CHF, however, whether increased MMP9 suppressed autophagic activity in CHF is unknown. This study aimed to determine....

The beauty of #Nebaska
11/21/2020

The beauty of #Nebaska

A calm end to an autumnal day; have a great weekend!

@ Cheyenne State Recreation Area, Hall County

How does neutrophil signaling during myocardial infarction wound repair work? Click the link and find out.https://pubmed...
11/09/2020
Neutrophil signaling during myocardial infarction wound repair - PubMed

How does neutrophil signaling during myocardial infarction wound repair work? Click the link and find out.

https://pubmed.ncbi.nlm.nih.gov/33122000/

Neutrophils are key effector cells of the innate immune system, serving as a first line of defense in the response to injury and playing essential roles in the wound healing process. Following myocardial infarction (MI), neutrophils infiltrate into the infarct region to propagate inflammation and be...

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UNMC Center for Heart and Vascular Research

Welcome from Director

Thank you for visiting the Center for Heart and Vascular Research (CHVR). Our goal is to support and empower cardiovascular research efforts at UNMC that will bring new understanding and treatment options for patients with heart or vascular disease. The Center also provides our trainees with the knowledge and skills they need to succeed in research. CHVR is part of ongoing efforts at UNMC to develop the clinical, research, and education missions focused on cardiovascular disease. We appreciate your interest in the center and look forward to hearing from you.

Merry L. Lindsey, Ph.D.

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