UNMC Center for Heart and Vascular Research

UNMC Center for Heart and Vascular Research Our goal is to support and empower cardiovascular research efforts at UNMC that will bring new understanding and treatment options for patients with heart or vascular disease.

We appreciate your interest in the center and look forward to hearing from you.

Operating as usual

Check out this article to see what the Case lab has been up to. https://pubmed.ncbi.nlm.nih.gov/32890698/
01/04/2021
Peripheral inflammation is strongly linked to elevated zero maze behavior in repeated social defeat stress - PubMed

Check out this article to see what the Case lab has been up to.
https://pubmed.ncbi.nlm.nih.gov/32890698/

Post-traumatic stress disorder (PTSD) is a psychiatric illness that results in an increased risk for a variety of inflammatory diseases. The exact etiology of this increased risk is unknown, and thus several animal models have been developed to investigate the neuroimmune interactions of PTSD. Repea...

Congrats CHVR members Alicia Schiller, Ioannis Chatzizisis, Hanjun Wang, Irving Zucker
12/16/2020
Dr. Irving H. Zucker on Twitter

Congrats CHVR members Alicia Schiller, Ioannis Chatzizisis, Hanjun Wang, Irving Zucker

“Team explores drug-free hypertension treatment | UNMC https://t.co/dqdJtNSjkU via @twitterapi This should bring new validation technology to renal denervation right in the cath lab.”

How does Inhibition of Pyk2 and Src activity improve Cx43 gap junction intercellular communication? Open the link to fin...
12/14/2020
Inhibition of Pyk2 and Src activity improves Cx43 gap junction intercellular communication - PubMed

How does Inhibition of Pyk2 and Src activity improve Cx43 gap junction intercellular communication? Open the link to find out.
https://pubmed.ncbi.nlm.nih.gov/32956670/

Identification of proteins that interact with Cx43 has been instrumental in the understanding of gap junction (GJ) regulation. An in vitro phosphorylation screen identified that Protein tyrosine kinase 2 beta (Pyk2) phosphorylated purified Cx43CT and this led us to characterize the impact of this ph...

Read this article to find out what increases autophagic flux in chronic heart failure. #patelhttps://pubmed.ncbi.nlm.nih...
11/23/2020
MMP9 inhibition increases autophagic flux in chronic heart failure - PubMed

Read this article to find out what increases autophagic flux in chronic heart failure. #patel
https://pubmed.ncbi.nlm.nih.gov/33064567/

An increased matrix metalloprotease9 (MMP9) during post-myocardial infarction (post-MI) exacerbates ischemia-induced chronic heart failure (CHF). Autophagy is cardioprotective during CHF, however, whether increased MMP9 suppressed autophagic activity in CHF is unknown. This study aimed to determine....

The beauty of #Nebaska
11/21/2020

The beauty of #Nebaska

A calm end to an autumnal day; have a great weekend!

@ Cheyenne State Recreation Area, Hall County

How does neutrophil signaling during myocardial infarction wound repair work? Click the link and find out.https://pubmed...
11/09/2020
Neutrophil signaling during myocardial infarction wound repair - PubMed

How does neutrophil signaling during myocardial infarction wound repair work? Click the link and find out.

https://pubmed.ncbi.nlm.nih.gov/33122000/

Neutrophils are key effector cells of the innate immune system, serving as a first line of defense in the response to injury and playing essential roles in the wound healing process. Following myocardial infarction (MI), neutrophils infiltrate into the infarct region to propagate inflammation and be...

UNMC Center for Heart and Vascular Research's cover photo
10/20/2020

UNMC Center for Heart and Vascular Research's cover photo

UNMC Center for Heart and Vascular Research's cover photo
10/20/2020

UNMC Center for Heart and Vascular Research's cover photo

10/20/2020

Congratulations to Jason Cook, MD, PhD from the Division of Vascular Surgery, on receiving the UNMC Physician Scientist Award. This award recognizes his achievements as a physician scientist and provides 2 years of research support. His lab studies the mechanoregulation of vascular physiology in Marfan Syndrome. Well done, Dr. Cook.

Read this article to find out what the Patel lab has been up to.https://pubmed.ncbi.nlm.nih.gov/32800589/
10/19/2020
Angiotensin-converting enzyme 2 activator, DIZE in the basolateral amygdala attenuates the tachycardic response to acute stress by modulating glutamatergic tone - PubMed

Read this article to find out what the Patel lab has been up to.
https://pubmed.ncbi.nlm.nih.gov/32800589/

The basolateral amygdala (BLA) is critical in the control of the sympathetic output during stress. Studies demonstrated the involvement of the renin-angiotensin system components in the BLA. Angiotensin-(1-7) [Ang-(1-7)], acting through Mas receptors, reduces stress effects. Considering that angiote...

Find out the quantification of Renal Sympathetic Vasomotion by checking out this articlehttps://pubmed.ncbi.nlm.nih.gov/...
10/12/2020
Quantification of Renal Sympathetic Vasomotion as a Novel End Point for Renal Denervation - PubMed

Find out the quantification of Renal Sympathetic Vasomotion by checking out this article

https://pubmed.ncbi.nlm.nih.gov/32829663/

Renal sympathetic denervation, a potentially revolutionary interventional treatment for hypertension, faces an existential problem due to the inability to confirm successful ablation of the targeted renal sympathetic nerves. Based on the observation that renal sympathetic nerve activity exerts rhyth...

Read this article to find out the cardiac expression pattern of the TRPV1 receptor- this team used a transgenic reporter...
09/30/2020
Identification of Cardiac Expression Pattern of Transient Receptor Potential Vanilloid Type 1 (TRPV1) Receptor using a Transgenic Reporter Mouse Model - PubMed

Read this article to find out the cardiac expression pattern of the TRPV1 receptor- this team used a transgenic reporter mouse model-
https://pubmed.ncbi.nlm.nih.gov/32841712/

Transient receptor potential vanilloid type 1 (TRPV1) channels are structurally related, non-selective cation channels that exhibit a high permeability to calcium. Sensory nerve endings expressing TRPV1 channels play a prominent role in regulating the cardiac sympathetic afferent reflex and contribu...

09/29/2020

Congratulations to our CIP member!
Dr. Steven Samson, who received his R56 NOA. His grant title is, “Role of ANGII in mediating K secretion with a high K diet”

Does a nanoformulation of the superoxide dismutase mimetic prevent its hypotension side effect? Follow this link to find...
09/23/2020
Nanoformulation of the superoxide dismutase mimic, MnTnBuOE-2-PyP 5+, prevents its acute hypotensive response - PubMed

Does a nanoformulation of the superoxide dismutase mimetic prevent its hypotension side effect? Follow this link to find out.
https://pubmed.ncbi.nlm.nih.gov/32863236/

Scavenging superoxide (O2•-) via overexpression of superoxide dismutase (SOD) or administration of SOD mimics improves outcomes in multiple experimental models of human disease including cardiovascular disease, neurodegeneration, and cancer. While few SOD mimics have transiti...

09/21/2020

Congratulations to our CIP team:

Charice Bryson, who has passed her notary test and is available to notarize. Well done, Charice!

Dr. Pam Carmines, who helped get approval for funding to upgrade technology in the DRC conference rooms. We ALL thank you, Pam!

Dr. Lie Gao and colleagues for the recent acceptance in J Physiol: "Functional, Proteomic, and Bioinformatic Analyses of Nrf2- and Keap1- Null Skeletal Muscle". Good job, Lie, Harold, Irv, Song, Tara, Ahmed, and Hanjun
#cellular #integrative #physiology

Let's see what the Case lab is up to! #peripheralinflammation #socialdeafeat #stresshttps://pubmed.ncbi.nlm.nih.gov/3289...
09/14/2020
Peripheral inflammation is strongly linked to elevated zero maze behavior in repeated social defeat stress - PubMed

Let's see what the Case lab is up to! #peripheralinflammation #socialdeafeat #stress

https://pubmed.ncbi.nlm.nih.gov/32890698/

Post-traumatic stress disorder (PTSD) is a psychiatric illness that results in an increased risk for a variety of inflammatory diseases. The exact etiology of this increased risk is unknown, and thus, several animal models have been developed to investigate the neuroimmune interactions of PTSD. Repe...

UNMC Center for Heart and Vascular Research's cover photo
09/09/2020

UNMC Center for Heart and Vascular Research's cover photo

Beautiful Nebraska Sunset(Photo credit: UNMC #Physiology member Hamid-Reza Shahshahan)
09/02/2020

Beautiful Nebraska Sunset

(Photo credit: UNMC #Physiology member Hamid-Reza Shahshahan)

08/31/2020

Congratulations to our CHVR members who were just promoted:

Bin Duan, PhD, Internal Medicine - Associate Professor with Tenure
Ioannis S. Chatzizisis, MD, Internal Medicine (CIP Courtesy Appt) - Professor with Tenure
Yulong Li, MD, PhD, - Emergency Medicine (CIP Courtesy Appt)- Professor with Tenure

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985850 Nebraska Medical Center
Omaha, NE

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UNMC Center for Heart and Vascular Research

Welcome from Director

Thank you for visiting the Center for Heart and Vascular Research (CHVR). Our goal is to support and empower cardiovascular research efforts at UNMC that will bring new understanding and treatment options for patients with heart or vascular disease. The Center also provides our trainees with the knowledge and skills they need to succeed in research. CHVR is part of ongoing efforts at UNMC to develop the clinical, research, and education missions focused on cardiovascular disease. We appreciate your interest in the center and look forward to hearing from you.

Merry L. Lindsey, Ph.D.

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