07/29/2026
This article from Rothman Orthopedics mentions menopause, but the advice for healthy longevity applies to men and women. There are several activities suggested throughout the article, centered around nutrition and staying active.
July 14th, 2026 - Saloni Sharma, MD
Better Bone & Muscle Health in Aging and Menopause
Tips to Reduce Inflammation, Muscle Loss, and Bone Loss
A wide range of age-related, hormonal changes can impact musculoskeletal health, especially for peri-menopausal women. These changes can lead to a condition known as Musculoskeletal Syndrome of Menopause, a collection of symptoms and conditions that negatively impact bones, joints, and muscles. Understanding the processes behind this syndrome and how to reduce its effects to maintain a higher quality of life as we age. In this blog post, we will explore how menopause affects musculoskeletal health and what strategies can be used to reduce inflammation, combat sarcopenia (loss of muscle), prevent osteoporosis, and manage arthritis.
This piece is for education only and is not medical advice. Any health changes, including exercise programs and supplement intake, should be discussed with your own physician.
What is Musculoskeletal Syndrome of Menopause?
The Musculoskeletal Syndrome of Menopause refers to the physical changes that occur during and after menopause, primarily due to a decrease in estrogen levels. Estrogen is a hormone that plays a significant role in maintaining bone density, muscle mass, and joint health. As estrogen levels drop during menopause, it can lead to a variety of musculoskeletal issues, including:
Increased inflammation in the joints and muscles
Sarcopenia, or the loss of muscle mass and strength
Decreased satellite cell proliferation, which affects muscle repair and regeneration
Osteoporosis, a condition characterized by weakened bones
Arthritis, including osteoarthritis, which is more common in postmenopausal women
These conditions can lead to pain, stiffness, decreased mobility, and an increased risk of fractures, making it critical to understand the underlying processes and how to address them effectively.
Reducing Inflammation: The Key to Joint Health
Inflammation is a natural response to the body’s immune system from injury or infection, but chronic inflammation can lead to pain, stiffness, and long-term damage to the joints, muscles, and bones. During menopause, the drop in estrogen can trigger an increase in inflammatory markers (chemicals) in the body, which can exacerbate conditions like arthritis.
Strategies to Reduce Inflammation:
Anti-Inflammatory Diet: Certain foods have been shown to reduce inflammation in the body. Incorporating omega-3 fatty acids found in fatty fish (like salmon and mackerel), flaxseeds, and walnuts can help lower inflammation. Additionally, adding turmeric and ginger to your meals can further reduce inflammation due to their natural anti-inflammatory compounds.
Exercise: Regular low-impact exercises like walking, swimming, and cycling can help manage inflammation by improving circulation and reducing stiffness. Yoga and tai chi also promote flexibility and muscle strength while reducing stress, which can exacerbate inflammation.
Supplements: Natural supplements like curcumin (found in turmeric) and Boswellia have shown promise in reducing inflammation. Omega-3 supplements, such as fish oil, can also be beneficial for reducing chronic inflammation associated with menopause. These must be cleared by your physician.
Combating Sarcopenia: Preserving Muscle Mass and Strength
Sarcopenia the loss of muscle mass and strength, is a significant concern for postmenopausal women. With the decline in estrogen, there is also a decrease in the body's ability to maintain muscle mass. This results in frailty, decreased functional capacity, and increased fall risk.
Strategies to Combat Sarcopenia:
Strength Training: Engaging in regular resistance training (such as using weights, resistance bands, or bodyweight exercises) can help preserve muscle mass and prevent sarcopenia. Exercises like squats, lunges, push-ups, and planks can effectively target different muscle groups.
Adequate Protein Intake: Protein plays a key role in muscle repair and growth. Women in menopause should aim to consume sufficient amounts of high-quality protein sources, including lean meats, fish, tofu, eggs, and legumes. Research suggests that increasing protein intake may help preserve muscle mass during menopause. In some conditions (kidney disease, etc.) protein must be monitored, so be sure to consult with your physician or a dietician to determine the best diet.
Vitamin D and Calcium: Both of these nutrients are vital for muscle function. Vitamin D enhances calcium absorption and supports muscle strength, while calcium is essential for overall muscle and bone health. Consider incorporating foods like fortified milk, leafy greens, and citrus fruits to boost your intake.
Decreased Satellite Cell Proliferation: Slowing Muscle Regeneration
Satellite cells are specialized cells involved in muscle repair and regeneration. As women approach menopause, satellite cell proliferation decreases, meaning muscles are less capable of regenerating after stress or injury. This reduction can contribute to the loss of muscle mass and strength.
Strategies to Support Muscle Regeneration:
Progressive Resistance Training: Gradually increasing the intensity of strength training exercises can stimulate satellite cell activity. It’s important to push your muscles to work harder over time to encourage regeneration and repair.
Adequate Sleep and Rest: Recovery is just as important as exercise. Ideally, 7-9 hours of quality sleep each night provides the body with the time it needs to repair and regenerate muscle tissues. Poor sleep can impair muscle recovery and satellite cell function.
Creatine Supplements: Creatine is a naturally occurring compound that plays a role in muscle energy metabolism. Studies have shown that creatine supplementation can improve muscle regeneration and strength in postmenopausal women. It may be an effective supplement to help mitigate the effects of reduced satellite cell proliferation if cleared by your physician.
Preventing Osteoporosis: Strengthening Bones During Menopause
Osteoporosis is a condition characterized by weakened bones, increasing the risk of fractures. Estrogen plays a key role in maintaining bone density, and its decline during menopause can lead to significant bone loss, particularly in the spine, hips, and wrists. At Rothman Orthopaedics, we often treat fractures surgically and encourage patients to focus on optimizing bone health to help prevent these fractures.
Strategies to Prevent Osteoporosis:
Weight-Bearing Exercise: Regular weight-bearing activities like walking, hiking, and running stimulate bone formation and help prevent bone loss. Strength training also plays a role in improving bone density by promoting bone remodeling.
Calcium and Vitamin D: Ensure adequate intake of calcium and vitamin D, which are critical for bone health. Aim for a daily intake of at least 1,200 mg of calcium and 600-800 IU of vitamin D, depending on age. Foods like dairy products, fortified cereals, and leafy greens can help meet these nutritional needs.
Bone-Boosting Food & Supplements: Consider increasing your dietary food intake of foods rich in calcium, magnesium, and vitamin K2, all of which play important roles in bone health. Always consult with a healthcare provider before starting any new supplement.
Managing Arthritis: Alleviating Pain and Stiffness
Arthritis, including osteoarthritis, becomes more common in postmenopausal women due to hormonal changes and decreased joint lubrication. Osteoarthritis, the most common type of arthritis, is characterized by the breakdown of cartilage, leading to joint pain and stiffness from “wear and tear.”
Strategies to Manage Arthritis:
Anti-Inflammatory Diet: As mentioned earlier, a diet rich in omega-3 fatty acids, antioxidants, and anti-inflammatory foods like berries, leafy greens, and turmeric can help reduce the inflammation associated with arthritis.
Joint Mobility Exercises: Low-impact activities such as swimming, cycling, and tai chi can help improve joint mobility without exacerbating pain. Additionally, gentle stretching and range-of-motion exercises can maintain flexibility and reduce stiffness.
Topical Treatments: Using capsaicin creams or turmeric-based ointments may help reduce joint pain. Topical treatments can provide localized relief without the systemic side effects of oral medications.
Physical Therapy: If arthritis is significantly affecting mobility, working with a physical therapist can help design a program to strengthen muscles around the affected joints, improving function and reducing pain.
Conclusion: A Comprehensive Approach to Menopausal Musculoskeletal Health
The musculoskeletal syndrome of menopause affects many women as they age, but understanding the processes behind this syndrome can empower women to act. By focusing on reducing inflammation, combating sarcopenia, supporting satellite cell proliferation, preventing osteoporosis, and managing arthritis, women can greatly improve their quality of life and maintain physical function well into their later years.
Adopting a combination of nutrition, exercise, sleep, and stress management strategies is key to maintaining healthy bones, muscles, and joints during and after menopause. Prioritize a balanced diet, regular physical activity, and supportive lifestyle choices to minimize the impact of menopausal musculoskeletal changes. If you’re dealing with severe symptoms, be sure to consult your healthcare provider for personalized guidance and treatment options.
To schedule a consultation with me or one of the other orthopedic specialists here at Rothman, visit our Appointments page today.
Key References
Wright, Vonda J et al. “The musculoskeletal syndrome of menopause.” Climacteric: the journal of the International Menopause Society vol. 27,5 (2024): 466-472. doi:10.1080/13697137.2024.2380363
Sharma, Saloni. The GRIT Protocol: How to Activate Your Natural GLP-1 and Strengthen Muscle in Midlife & Beyond (2026).