Brain Health Registry

Brain Health Registry A groundbreaking online project developed by UCSF researchers to speed up clinical trials seeking treatments for Alzheimer's, Parkinson's, PTSD and other brain diseases and disorders.
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The Brain Health Registry - led by top medical researchers at UCSF and other leading scientific institutions - is a groundbreaking web-based project designed to accelerate clinical trials seeking treatments for Alzheimer’s, Parkinson's, depression, PTSD, and other brain disorders. Participation is safe, easy and free. Go to www.brainhealthregistry.org to sign up today.

Very interesting research relating exercise with memory ability."When people first begin exercising, he points out, thei...
05/03/2019
How Exercise Affects Our Memory

Very interesting research relating exercise with memory ability.

"When people first begin exercising, he points out, their muscles strain and burn through energy. But as they become fitter, those same muscles respond more efficiently, using less energy for the same work.

The scientists suspect that, in the same way, the spike in brain activity after a first session of biking is the prelude to tissue remodeling that, with continued exercise, improves the function of those areas."

Even a single workout may make our brain’s memory centers, like our muscles, more fit.

Alzheimer's disease misdiagnosis is surprisingly common; this is in part due to not knowing how to understand very simil...
05/01/2019
A mysterious dementia that mimics Alzheimer’s gets named LATE

Alzheimer's disease misdiagnosis is surprisingly common; this is in part due to not knowing how to understand very similar diseases that are not Alzheimer's. This is a great step forward in understanding and will help with proper diagnosis and therefore treatment!

An underappreciated form of dementia that causes memory trouble in older people gets a name: LATE.

CIND | Center for Imaging of Neurodegenerative Diseases
04/29/2019
CIND | Center for Imaging of Neurodegenerative Diseases

CIND | Center for Imaging of Neurodegenerative Diseases

Alzheimer's is just one type of dementia. This article from
U.S. News and World Report provides a great overview of vascular dementia and features Dr. Bruce Miller of UCSF School of Medicine.

CIND | Center for Imaging of Neurodegenerative Diseases
04/26/2019
CIND | Center for Imaging of Neurodegenerative Diseases

CIND | Center for Imaging of Neurodegenerative Diseases

Researchers may be closing in on a way to check athletes while they’re alive for signs of a degenerative brain disease that’s been linked to frequent head blows. Experimental scans found higher levels of an abnormal protein tied to the disease in a study of former NFL players who were having mood and thinking problems. It’s the first time a major study has tested these scans for detecting chronic traumatic encephalopathy, or #CTE, which is only diagnosed now after death, with brain autopsies. CIND’s imaging expert, Dr. Michael Weiner, is mentioned in the TIME article regarding said study. Link below.

Can a video game detect Alzheimer's disease before the onset of symptoms? Some new research showing that this may be a p...
04/26/2019
A video game aids in research on Alzheimer’s disease | Drupal

Can a video game detect Alzheimer's disease before the onset of symptoms? Some new research showing that this may be a possibility!

How do we find our way around? Why do I always get lost while my friend never does? Why does people's sense of direction vary so widely in general? Is it linked to inherent, genetic characteristics or determined by cultural factors?

New advancement in the IDEAS study! This focuses on the effectiveness of proper diagnosis and treatment of the disease -...
04/24/2019
Alzheimer’s Diagnosis, Management Improved by Brain Scans

New advancement in the IDEAS study! This focuses on the effectiveness of proper diagnosis and treatment of the disease -- and shows just how effective it can be.

First Phase of Nationwide Study Demonstrates Clinical Impact of Amyloid PET Imaging

Can external stimulation help with issues related brain aging? Scientists are working to determine.
04/22/2019
Scientists Test Whether Brain Stimulation Could Help Sharpen Aging Memory

Can external stimulation help with issues related brain aging? Scientists are working to determine.

Memory faltering as you age? Parts of your brain that used to work in sync may be out of step. A study shows that a precise jolt of electricity can bring these parts back together, boosting memory.

Alzheimer's disease often co-occurs with other age-related illnesses. There might be more connections than previously th...
04/10/2019
The Diagnosis Is Alzheimer’s. But That’s Probably Not the Only Problem.

Alzheimer's disease often co-occurs with other age-related illnesses. There might be more connections than previously thought!

Most people with dementia have a number of brain abnormalities, not just Alzheimer’s disease. The finding is forcing scientists to rethink the search for treatments.

Progress in genetic-based treatment of neurodegenerative diseases like Alzheimer's disease and Parkinson's!
04/08/2019
Combating Alzheimer's by restoring the brain's cleanup crew

Progress in genetic-based treatment of neurodegenerative diseases like Alzheimer's disease and Parkinson's!

The brain's microglia scout around the brain for debris such as damaged neurons and protein plaques. A Stanford University team has discovered that CD22 prevents this important function and tuning it down improves cognitive function in aged mice.

Our April newsletter is out today. This newsletter is about new research we are doing on Hoarding Disorder and its relat...
04/03/2019
Brain Health Registry Newsletter - April 2019 | Brain Health Registry

Our April newsletter is out today. This newsletter is about new research we are doing on Hoarding Disorder and its relationship to brain health!

Hoarding Disorder is a growing problem. According to the American Psychiatric Association (APA), it affects 2 to 6 percent of people in the United States, and most commonly involves an individual’s inability to remove clutter from his or her living space. In some cases, this can create dangerous...

A new initiative to include African-Americans in genetic and neuroscientific research!"Unfortunately, the lack of divers...
04/01/2019
Black clergy launch first African-American Neuroscience Research Initiative

A new initiative to include African-Americans in genetic and neuroscientific research!

"Unfortunately, the lack of diversity has hindered progress on research on basic science and clinical trials in neuroscience. For instance, although people of European descent make up less than 16% of the world population, '81 percent of large-scale genomic datasets' are of that particular group.

Since it has been proven that there are differences in genetics between races and ethnicities, it is possible that genomic research has the ability to provide medical treatments that will be more suited for disorders such as heart disease, stroke, asthma, diabetes, amongst other medical disorders."

The country’s first African-American Neuroscience Research Initiative launched to provide more genomic research and neuroscience studies for Blacks.

An interview discussing how we can see and model Alzheimer's disease in scientific experiments.
03/27/2019
Watching Alzheimer’s in action

An interview discussing how we can see and model Alzheimer's disease in scientific experiments.

A look inside the brains of engineered mice suggests therapies might need to target two key proteins — tau and amyloid-beta — at the same time

Neurogenesis, a controversial theory that the adult brain may actually grow new neurons over time, if true would have ve...
03/25/2019
Debate about birth of new neurons in adult brains extends to Alzheimer’s disease

Neurogenesis, a controversial theory that the adult brain may actually grow new neurons over time, if true would have very interesting implications for the treatment of Alzheimer's and other neurodegenerative diseases!

The surprise finding that neurogenesis drops in diseased brains could throw open a new route to therapies.

Great article covering some of the harsh realities of Dementia -- and some possible ways to help!
03/22/2019
How Much a Dementia Patient Needs to Know

Great article covering some of the harsh realities of Dementia -- and some possible ways to help!

Oliver Sacks asks, Should a doctor replace an accustomed identity with a meaningless “reality”?

A fantastic example of why research must expand to understand many different groups of people! If it appears differently...
03/20/2019
Dementia looks different in brains of Latinos

A fantastic example of why research must expand to understand many different groups of people! If it appears differently in different people, both diagnosis and treatment of diseases will have to address these differences.

A first-of-its-kind study has uncovered dramatic racial differences in the brains of those with dementia.

These diseases though similar in symptoms are not all the same! Find out why it's so important to be able to distinguish...
03/18/2019
Is It Alzheimer's Or Another Dementia? The Right Answer Matters

These diseases though similar in symptoms are not all the same! Find out why it's so important to be able to distinguish them.

Many older people diagnosed with Alzheimer's actually have dementia caused by something else. Without the right diagnosis, these people are less likely to get the best care.

Just as there are many new proposed theories of the causes of Alzheimer's disease, there are many new treatments being t...
03/15/2019
An Hour of Light and Sound a Day Might Keep Alzheimer's at Bay

Just as there are many new proposed theories of the causes of Alzheimer's disease, there are many new treatments being tested for their effectiveness. This one simply uses light and sound!

Playing a flashing white light and a trilling sound reversed signs of Alzheimer’s in mice. Researchers are now trying it in humans

Many scientists are still unsure about the underlying cause of Alzheimer's disease. A theory that is growing in populari...
03/13/2019
Could Alzheimer's Be a Reaction to Infection?

Many scientists are still unsure about the underlying cause of Alzheimer's disease. A theory that is growing in popularity is the "pathogen model" of Alzheimer's, which possibly traces the disease to infectious diseases!

"Perhaps if researchers seriously consider the role of pathogens and examine their interactions with amyloid beta as well as the role of blood-brain barrier more carefully, then we will finally be able to overcome our current impasse in finding a cure. In Tanzi’s lab at Harvard Medical School, we are actively pursuing these avenues, developing cutting-edge technology for evaluating pathophysiological mechanisms involved in a three-dimensional cell culture model (more aptly known as “Alzheimer’s-in-a-Dish”). Only through these types of innovative approaches will we be able to accelerate the development of novel therapeutic approaches in the quest to treat and ultimately eradicate this enigmatic disease."

A relatively new and still controversial theory suggests the disease could be triggered by pathogens

A primary goal of the Brain Health Registry is to find new, accessible solutions to assessing those at-risk! This articl...
03/08/2019
Alzheimer's Screenings Often Left Out Of Seniors' Wellness Exams

A primary goal of the Brain Health Registry is to find new, accessible solutions to assessing those at-risk! This article is a great summary of the present situation.

A brief cognitive test can detect signs of Alzheimer's in older patients. Only half of primary care doctors routinely give one, despite coverage by Medicare as part of annual wellness visits.

New research efforts from the Brain Health Registry team toward developing diagnostic tools for brain disorders! Check o...
03/06/2019
UCSF’s Top NIH-Funded Projects of 2018

New research efforts from the Brain Health Registry team toward developing diagnostic tools for brain disorders! Check out a description of the new funding we've received here.

"After developing the online tests, the researchers hope to validate them with a four-year-long study of 520 participants, who will take both the in-clinic and online versions of the tests.

“The major goal is to demonstrate that the online versions will be comparable to the clinical versions in terms of diagnostic performance,” said Weiner."

More than a thousand projects across the University received federal funding from the National Institutes of Health in 2018, totaling more than $647.8 million.

Great article on AI and Alzheimer's disease, featuring our own Dr. Michael Weiner!“How artificial intelligence is goin...
03/04/2019
Training AI to Predict Alzheimer’s Disease

Great article on AI and Alzheimer's disease, featuring our own Dr. Michael Weiner!

“How artificial intelligence is going to work with this is all very exciting. There is a lot of new technology, hype, and promise,” says Michael Weiner, ADNI’s principal investigator and a professor at the University of California, San Francisco. Weiner was not involved in the recent Canadian study. “It’s just a little early to tell because it depends on whether or not we are missing something by just looking at the data in our brains,” he explains.

...

“The big question for a study like this is, ‘What is going to be the long-term impact?’” adds Weiner. “There are so many projects that have had interesting results but have not been replicated or led to anything in diagnosis or treatment.”

Chakravarty believes his research team’s approach is more sensitive than previous attempts because it is multimodal, using different types of data — not just magnetic resonance imagery. “We found that you can get a very nuanced prognosis compared to other methods,” he says.

It’s challenging to diagnose Alzheimer’s cases early and accurately, but scientists are hoping AI can be applied to brain scans to help.

As the aging United States population becomes increasingly diverse, scientists are investigating Alzheimer’s disease a...
03/01/2019
Some Alzheimer's biomarkers differ by race, NIA-funded study finds

As the aging United States population becomes increasingly diverse, scientists are investigating Alzheimer’s disease and related disorders in under-represented populations. This presents an enormous opportunity to advance the understanding of AD and its differences between populations. Check out findings from a recent NIA study which researched racial differences in AD biomarkers!

An NIA-supported study finding racial differences in some Alzheimer’s biomarkers suggests the disease may develop differently in African Americans compared to whites.

There is a growing idea that Alzheimer's disease must be approached from a new perspective in order to be most effective...
02/27/2019
Changing ‘the tragedy narrative’: Why a growing camp is promoting a more joyful approach to Alzheimer’s

There is a growing idea that Alzheimer's disease must be approached from a new perspective in order to be most effectively treated!

From the article:

Jennifer Carson, director of the newly launched Dementia Engagement, Education and Research program at the University of Nevada at Reno, encourages this kind of engagement.

“Alzheimer’s can be a liberating event, an opportunity to fly,” she said. “This is in no way to dismiss the pain and suffering that comes from dementia, but to understand that a lot of that pain and suffering comes from the response.”

Viewing the disease in a more adaptive way — with openness and humor -- is helping some caregivers and patients alike.

Scientists are now attempting a new gene therapy treatment for Alzheimer's disease!"The clinical trial, led by Ronald Cr...
02/25/2019
Doctors plan to test a gene therapy that could prevent Alzheimer’s disease

Scientists are now attempting a new gene therapy treatment for Alzheimer's disease!

"The clinical trial, led by Ronald Crystal at Weill Cornell Medicine in Manhattan, is a novel tactic against dementia as well as a new twist for gene therapy. Most gene replacement efforts, which rely on viruses to carry DNA instructions into a person’s cells, aim to fix rare diseases such as hemophilia by replacing a single malfunctioning gene.

But common diseases don’t have singular causes, so gene therapy has never seemed as promising. The Alliance for Regenerative Medicine, a trade group, says it knows of no gene therapies currently being tried on patients with Alzheimer’s disease."

A novel dementia treatment will flood people’s brains with a low-risk version of a key gene.

Although women may be more at risk for Alzheimer's than men, according to some researchers, women's brains actually age ...
02/22/2019
Women seem to have younger brains than men the same age

Although women may be more at risk for Alzheimer's than men, according to some researchers, women's brains actually age more slowly than men's overall.

Women have a brain age 3.8 years younger than men on average, which may help explain why they are more likely to stay mentally sharp in later years

Help the Brain Health Registry celebrate Black History Month!Alzheimer’s Disease poses a special risk to African Ameri...
02/15/2019
Alzheimer's Disease May Develop Differently In African-Americans, Study Suggests

Help the Brain Health Registry celebrate Black History Month!

Alzheimer’s Disease poses a special risk to African Americans. Studies show that they’re up to twice as likely than White Americans to develop the disease. Scientist may have found a biological difference that might explain the racial disparity. Dr. John Morris explains, “to truly understand how Alzheimer’s disease works in people who aren’t white… more researchers will have to reach out to groups that have been wary of scientific studies”.

Participation in the Brain Health Registry is an innovative and convenient way to contribute to brain health research and we also identify studies that we think our members are eligible to participate in.

Click here to join: https://my.brainhealthregistry.org/BHR/register

Black Americans are more likely than whites to develop Alzheimer's. Yet black people studied appeared to have lower levels of a toxic substance associated with the disease, researchers say.

A complicating factor in Alzheimer's disease research is that it appears to affect men and women differently. Researcher...
02/13/2019
Why Women? — Studying the Role of Gender in Alzheimer’s Disease | UAHS Office of Public Affairs

A complicating factor in Alzheimer's disease research is that it appears to affect men and women differently. Researchers at the University of Arizona are trying to understand why!

"Women with Alzheimer’s exhibit a broader range of dementia-related behaviors and greater cognitive decline than men as the disease progresses. Studies have found evidence that women’s brains are more vulnerable to Alzheimer’s than men’s, but the reasons are unknown. Dr. Brinton’s study aims to define the biochemical pathways that lead to sex differences in the disease."

Breakthrough research on conscious awareness shows that it is not limited to a single part of the brain but rather can b...
02/11/2019
How we identified brain patterns of consciousness

Breakthrough research on conscious awareness shows that it is not limited to a single part of the brain but rather can be found when looking at well-orchestrated patterns across the brain!

"We found two main patterns of communication across regions. One simply reflected physical connections of the brain, such as communication only between pairs of regions that have a direct physical link between them. This was seen in patients with virtually no conscious experience. One represented very complex brain-wide dynamic interactions across a set of 42 brain regions that belong to six brain networks with important roles in cognition (see image above). This complex pattern was almost only present in people with some level of consciousness."

Specific brain networks are at work when we are conscious. New results can help distinguish truly unconscious patients from those who have some degree of consciousness.

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