Brain Health Registry

Brain Health Registry A groundbreaking online project developed by UCSF researchers to speed up clinical trials seeking treatments for Alzheimer's, Parkinson's, PTSD and other brain diseases and disorders.
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The Brain Health Registry - led by top medical researchers at UCSF and other leading scientific institutions - is a groundbreaking web-based project designed to accelerate clinical trials seeking treatments for Alzheimer’s, Parkinson's, depression, PTSD, and other brain disorders. Participation is safe, easy and free. Go to www.brainhealthregistry.org to sign up today.

A new theory about Alzheimer's suggests that it may not be entirely a factor to genetic inheritance. It also suggests th...
01/10/2019
A New Idea about What Triggers Alzheimer's

A new theory about Alzheimer's suggests that it may not be entirely a factor to genetic inheritance. It also suggests that, if true, we already have medications to treat it!

Also a special treat of a very interesting topic in this article: "genomic mosaicism." DNA sequences vary from cell to cell, which means that even the individual cells that make up our brain are not uniform. They are a diverse composite of many different variations of DNA!

Changes in brain cells’ DNA may be responsible—and if so, medicines already developed for other diseases might be used to treat it

Ever heard of irisin? Now you have! This special hormone, named after the Greek goddess Iris, is implicated in explainin...
01/07/2019
Exercise hormone may help combat Alzheimer’s, research suggests

Ever heard of irisin? Now you have! This special hormone, named after the Greek goddess Iris, is implicated in explaining why exercise has such a strong effect preventing Alzheimers, according to new research from Nature Medicine released just today.

Drugs based on the hormone irisin could help to stave off dementia in physically inactive patients, scientists claim.

New research has recently shown the deep interconnection between the brain and the immune system! We used to think they ...
01/02/2019
Brain, The Immune System And Stress: Ultimately Connected, New Studies Suggest

New research has recently shown the deep interconnection between the brain and the immune system! We used to think they were quite separate, now we know differently.

From the article: "These astonishing revelations puts a spin on our understanding of what the way the brain and the immune system interacts and the implications it has."

For a long time the immune system and the brain were thought to be divorced from each other. A new body of research published in the Scientific American suggests that they are connected. This has implications on stress and how we process it.

What makes a solid contribution to "living well" with dementia? According to new research from the University of Exeter:...
12/31/2018
Optimism, self-esteem and physical health important for living well with dementia

What makes a solid contribution to "living well" with dementia? According to new research from the University of Exeter: optimism, self-esteem, and physical health! Link to scientific publication in article.

NIHR researchers have identified that optimism, self-esteem and physical health - along with a number of other factors - are important factors for enabling people with dementia and their carers to live as well as possible.

New methods to discover Alzheimer's and other degenerative brain diseases are being developed regularly. This one 'light...
12/28/2018
Scientists develop brain scan to detect Alzheimer’s disease by ‘lighting up’ dementia-causing plaques

New methods to discover Alzheimer's and other degenerative brain diseases are being developed regularly. This one 'lights up' your brain so that scientists can see its structure!

Lifestyle Scientists develop brain scan to detect Alzheimer’s disease by ‘lighting up’ dementia-causing plaques By Agencies Published : December 17, 2018 | Updated : December 17, 2018 Twitter Facebook Email Whatsapp linkedin Google+ More Share this article Twitter Facebook Email Whatsapp linke...

More and more findings are emerging that show correlations with lifestyle and brain health. That means you can be an adv...
12/26/2018
Diet and Exercise Might Reverse Aging in the Brain

More and more findings are emerging that show correlations with lifestyle and brain health. That means you can be an advocate for your own brain health with basic lifestyle changes! It's never too late! More details in the article.

According to a new study

In a big picture view, Alzheimer's disease does not have a singular effect. It has many effects that are a consequence o...
12/21/2018
Many Alzheimer’s patients experience ‘sundowning,’ or strong mood swings late in the day. The cause is a mystery.

In a big picture view, Alzheimer's disease does not have a singular effect. It has many effects that are a consequence of its predominance in the brain. We can all make a difference in the lives of our loved ones and communities by being aware of and prepared for those effects. This article outlines a great example of one of these effects and how we might approach it.

As the sun wanes, people with dementia can become agitated, disoriented and even aggressive, a real challenge for caregivers

Yet another way that the brain represents unique and fascinating attributes, with both benefits and drawbacks!"Scientist...
12/19/2018
‘Landmark study’ shows brain cells revamp their DNA, perhaps sparking Alzheimer’s disease

Yet another way that the brain represents unique and fascinating attributes, with both benefits and drawbacks!

"Scientists have seen hints that such genomic reshuffling—known as somatic recombination—happens in our brain. Neurons there often differ dramatically from one another. They often have more DNA or different genetic sequences than the cells around them."

Brain cells are some of the only body cells that can perform these alterations

The Brain Health Registry encourages you to make some time to relax this holiday season! We all need it, and studies sho...
12/17/2018
How you react to stress may predict brain health

The Brain Health Registry encourages you to make some time to relax this holiday season! We all need it, and studies show that learning healthy management of stress may very likely lead to better brain health.

New research suggests that the way we respond to minor daily stressors may affect our cognition and brain health well into old age.

New therapies and diagnostics are coming out regularly that show promise for the treatment of Alzheimer's disease. No ma...
12/14/2018
Saliva Test For Early Detection Of Alzheimer's Disease Delivers Promising Results - Study Finds

New therapies and diagnostics are coming out regularly that show promise for the treatment of Alzheimer's disease. No matter who you are, you can be part of the solution to this and other brain diseases by participating in the Brain Health Registry!

Catching the development of Alzheimer's disease early on can make a world of difference in helping to treat the devastating condition. Scientists have long sought to find accurate, easier methods of detecting the disease, and now a promising new study shows that a simple saliva test might just do th...

One of the primary rising issues with Alzheimer's is that there are several types of the disease. This makes both diagno...
12/07/2018
Researchers classify Alzheimer's patients into 6 subgroups

One of the primary rising issues with Alzheimer's is that there are several types of the disease. This makes both diagnosis and treatment much more nuanced than many might assume! Check out some of the latest research in an ongoing effort to understand Alzheimer's subtypes. The more we all know, the better!

Researchers studying Alzheimer’s disease have created an approach to classify patients with Alzheimer’s disease, a finding that may open the door for personalized treatments.

12/03/2018
BHR reaches 6,000 Facebook followers

BHR reaches 6,000 Facebook followers

Thank you all for the continued support and engagement with BHR! You are helping to revolutionize brain health research and accelerate the search for treatments to brain disease.

"Patients with moderate to severe depression reported significant improvements in mood when researchers precisely stimul...
12/03/2018
Brain Stimulation Relieves Depression Symptoms

"Patients with moderate to severe depression reported significant improvements in mood when researchers precisely stimulated a brain region called the orbitofrontal cortex (OFC)..."

Patients with moderate to severe depression reported significant improvements in mood when researchers precisely stimulated a brain region called the orbitofrontal cortex.

"these results suggest that repeated blows to the head could lead to changes in the shape of the corpus callosum, which ...
11/30/2018
Changes In Brain Scans Seen After A Single Season Of Football For Young Players

"these results suggest that repeated blows to the head could lead to changes in the shape of the corpus callosum, which is critical to integrating cognitive, motor and sensory functions between the two hemispheres of the brain, during a critical time for brain development in young people."

MRI scans of the brains of young football players suggest that repeated blows to the head can change the shape of nerve fibers in the corpus callosum, which connects the two halves of the brain.

This morning we released our November Newsletter! Please click below to learn more about our recent study partner resear...
11/29/2018
Brain Health Registry Newsletter - November 2018 | Brain Health Registry

This morning we released our November Newsletter! Please click below to learn more about our recent study partner research and new funding collaboration. We're incredibly excited about our research as well as what's to come here at the Brain Health Registry!

Now more than ever, there is a critical need to identify individuals who are at risk for Alzheimer’s disease. Here at the Brain Health Registry (BHR), we believe in leveraging the Internet to help meet this need. We thank you for your participation in the BHR, which allows us to address this impor...

"Some patients with memory issues and the early stages of dementia have had their conditions made worse by the chaos of ...
11/28/2018
After a Wildfire, Rebuilding Life Can Be Hardest for the Oldest

"Some patients with memory issues and the early stages of dementia have had their conditions made worse by the chaos of evacuation and by losing their daily routines..."

Many who fled the flames ravaging Paradise, Calif., were retirees with health problems and few resources. “Half of them don’t have it in them to start all over again,” a nursing supervisor at a shelter said.

This project, lead by neuroscientists at Stanford, intends to "...uncover molecules in the blood that affect... brain he...
11/19/2018
$9.6 million grant to fund research on vascular risk factors for brain aging, dementia

This project, lead by neuroscientists at Stanford, intends to "...uncover molecules in the blood that affect... brain health in aging and in people with vascular risk factors, including stroke and obesity" and therefore, "...develop a better understanding of age-related brain disorders such as Alzheimer’s disease."

The Stanford project, led by neuroscientists Tony Wyss-Coray and Marion Buckwalter, will focus on the influence of immune factors and systemic inflammation on the brain.

"“These results imply that [no matter] what causes what, cardiovascular and Alzheimer’s pathology co-occur because t...
11/16/2018
Alzheimer’s and Cardiovascular Disease Share Common Genetics in Some Patients

"“These results imply that [no matter] what causes what, cardiovascular and Alzheimer’s pathology co-occur because they are linked genetically.

That is, if you carry this handful of gene variants you may be at risk for not only heart disease but also Alzheimer’s,” said UCSF neurodegeneration researcher Rahul Desikan, MD, PhD"

Genetics may predispose some people to both Alzheimer’s disease and high levels of blood lipids such as cholesterol, a common feature of cardiovascular disease.

What is the point of sharing your diagnosis or raising awareness? It allows others to feel comfortable sharing their own...
11/14/2018
Dementia Is Getting Some Very Public Faces

What is the point of sharing your diagnosis or raising awareness?

It allows others to feel comfortable sharing their own experience. It encourages others to seek help if they have not done so already and can lead to earlier diagnoses. It can put a medical 'label' on the symptoms you may have, which may feel more reassuring and take away some fear of the unknown.

"Understanding the disease and its prognosis allows time to assemble a health care team, to mobilize family, to seek legal and financial advice."

And more.

Stigma often prevents patients from acknowledging an Alzheimer’s diagnosis. A series of high-profile disclosures may help change that.

"Researchers suggest several possible mechanisms that could link concussion and mental decline."More likely than not, ho...
11/07/2018
With Dangers of Everyday Concussions Revealed, Scientists Race to Find Solutions

"Researchers suggest several possible mechanisms that could link concussion and mental decline."

More likely than not, however, it is a combination of several things that vary from person to person.

UCSF scientists are working to understand how concussions cause long-term cognitive damage – and how they might be treated.

Tracking bracelets to help locate people is not a new concept. The bracelets described in the article are "equipped with...
11/05/2018
Some people with dementia wander away and get lost. A bracelet can help find them.

Tracking bracelets to help locate people is not a new concept. The bracelets described in the article are "equipped with a radio transmitter — to hundreds of municipal public-safety agencies around the country." Click the link to read more.

A major initiative in Los Angeles County tracks down missing people with Alzheimer’s, other cognitive conditions.

Although a fascinating read, we would like to emphasize the last part of the article, which states,"the study results on...
11/02/2018
Stress might lead to memory loss and brain shrinkage, study says

Although a fascinating read, we would like to emphasize the last part of the article, which states,

"the study results only show an association, not a cause, and more research is needed to tease out the relationship between high cortisol levels and dementia."

A highly stressful life may lead to memory loss and brain shrinkage before you turn 50, a new study says.

Using a special type of MRI, researchers at Washington University found that only "20 percent of the cerebellum was dedi...
10/31/2018
The Underestimated Cerebellum Gains New Respect From Brain Scientists

Using a special type of MRI, researchers at Washington University found that only "20 percent of the cerebellum was dedicated to areas involved in physical motion, while 80 percent was dedicated to areas involved in functions such as abstract thinking, planning, emotion, memory and language."

A brain structure that helps us walk in a straight line also appears to play a central role in emotional control and decision-making. The findings about the cerebellum challenge years of dogma.

UPI News Agency reports on UCSF's newly developed gene therapy that focuses on alleviating motor symptoms of Parkinson's...
10/29/2018
Gene therapy for Parkinson's disease symptoms shows promise

UPI News Agency reports on UCSF's newly developed gene therapy that focuses on alleviating motor symptoms of Parkinson's Disease:

A new gene therapy might help improve motor symptoms in people with Parkinson's disease who aren't responding to other therapies, an early study has found.

"Research shows that Alzheimer’s caregivers face significant physical, financial and mental burdens......Other researc...
10/26/2018
The Hidden Reasons Why Alzheimer's Caregivers Are So Stressed

"Research shows that Alzheimer’s caregivers face significant physical, financial and mental burdens...

...Other research suggests that dementia caregivers have higher levels of stress and depression than other types of caregivers."

They have higher rates of depression

To be in the public eye means to oftentimes share major aspects of your personal life with the world. As difficult as it...
10/24/2018
Justice Sandra Day O'Connor announces she has been diagnosed with dementia

To be in the public eye means to oftentimes share major aspects of your personal life with the world. As difficult as it may be to be a celebrity or famous figure and to announce something private such as an Alzheimer's diagnosis, it is commendable to shed light and spread awareness on diseases such as those related to dementia:

Retired Justice Sandra Day O'Connor revealed in a letter on Tuesday that she has been diagnosed with the "beginning stages of dementia, probably Alzheimer's disease."

"“If you got a depression diagnosis, one of the most basic things you want to know is, what are the chances of my life...
10/22/2018
What’s Life Like After Depression? Surprisingly, Little Is Known

"“If you got a depression diagnosis, one of the most basic things you want to know is, what are the chances of my life returning to normal or becoming optimal afterward?” said Jonathan Rottenberg, a professor of psychology at the University of South Florida.

“You’d assume we’d have an answer to that question. I think it’s embarrassing that we don’t.”"

Most research on depression focuses on the afflicted, a new paper argues, overlooking a potentially informative group: people who have recovered.

"Some researchers have sought new ways to help people [living with Alzheimer’s disease or other dementia] maintain the...
10/19/2018
Research shows importance of setting personal goals for dementia care

"Some researchers have sought new ways to help people [living with Alzheimer’s disease or other dementia] maintain the best quality of life as possible even as their conditions progressively worsen."

The study not only revealed the promise of goal attainment in dementia care, but also the importance of goal setting for caregivers, who are affected both emotionally and physically by their loved one’s illness.

"...post-ICU syndrome — a cluster of cognitive symptoms that can include anxiety, depression and post-traumatic stress...
10/17/2018
When ICU Delirium Leads To Symptoms Of Dementia After Discharge

"...post-ICU syndrome — a cluster of cognitive symptoms that can include anxiety, depression and post-traumatic stress disorder, as well as delirium — affects 30 to 50 percent of all patients who are rushed to the ICU because of a medical emergency."

Up to half of all patients who survive emergency medical treatment in the intensive care unit have mental problems when they return home. Doctors studying the problem say it starts with delirium.

The recent hurricane season has hit the US hard. What happens when those with dementia are caught in a storm's path?
10/15/2018
Helping Dementia Patients During a Hurricane

The recent hurricane season has hit the US hard. What happens when those with dementia are caught in a storm's path?

No matter whether they evacuate or stay put, storms can bring added confusion, disorientation, anxiety and paranoia to those with dementia.

"Mrs. Scherrer has bad days when she is “crying because I don’t know where I am,” she said, but “I have a passio...
10/12/2018
Leading an Active Life With a Diagnosis of Dementia

"Mrs. Scherrer has bad days when she is “crying because I don’t know where I am,” she said, but “I have a passion now, and that passion keeps me going.”

Most important, she said... she “can still live a meaningful, happy life, at least for now.”"

As the number of people with dementia rises, those with early stages of the ailment are pursuing fulfilling lives and making plans for future care.

What sorts of new things would you like to experience in life? Brain games? Testing new recipes with friends? Taking dif...
10/10/2018
A Brain Scientist Who Studies Alzheimer's Explains How She Stays Mentally Fit

What sorts of new things would you like to experience in life? Brain games? Testing new recipes with friends? Taking different paths when you walk the dog?

Share your ideas with us!

Alzheimer's prevention specialist Jessica Langbaum says that like most working people she gets plenty of mental exercise without playing crossword puzzles or brain games. She says work is the key.

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