12/10/2026
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THCV has been used for many purposes. A couple of which, are balancing blood sugar and appetite suppression. To help with your weight loss journey, this may be added in with GLP-1's or used by itself. Below you will find links to 13 different articles on this use.
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Research Articles
Tetrahydrocannabivarin is Not Tetrahydrocannabinol.
Haghdoost M, Peters EN, Roberts M, Bonn-Miller MO.Cannabis Cannabinoid Res. 2025 Feb;10(1):1-5. doi: 10.1089/can.2024.0051. Epub 2024 Jul 12.PMID: 38995871 Free PMC article. Review.
THCV has been reported to reduce blood sugar and act as an appetite suppressant in several independent pre-clinical studies, which has earned it the popular nickname of "diet w**d," despite few human studies of these effects. ...In this article, we examine what is k …
The role of tetrahydrocannabivarin (THCV) in metabolic disorders: A promising cannabinoid for diabetes and weight management.
Mendoza S.AIMS Neurosci. 2025 Mar 12;12(1):32-43. doi: 10.3934/Neuroscience.2025003. eCollection 2025.PMID: 40270953 Free PMC article. Review.
Animal models further revealed THCV's potential to suppress appetite, prevent hepatosteatosis, and improve metabolic homeostasis. Preliminary human trials support these findings, thereby showing that THCV may modulate appetite and glycemic control, tho …
delta9-Tetrahydrocannabivarin (THCV): a commentary on potential therapeutic benefit for the management of obesity and diabetes.
Abioye A, Ayodele O, Marinkovic A, Patidar R, Akinwekomi A, Sanyaolu A.J Cannabis Res. 2020 Jan 31;2(1):6. doi: 10.1186/s42238-020-0016-7.PMID: 33526143 Free PMC article.
The main advantage of THCV over THC is the lack of psychoactive effects. In rodent studies, THCVdecreases appetite, increases satiety, and up-regulates energy metabolism, making it a clinically useful remedy for weight loss and management of obesity and type …
CB1-independent mechanisms of delta9-THCV, AM251 and SR141716 (rimonabant).
Raffa RB, Ward SJ.J Clin Pharm Ther. 2012 Jun;37(3):260-5. doi: 10.1111/j.1365-2710.2011.01284.x. Epub 2011 Jul 11.PMID: 21740450 Review.
Weight Loss and Therapeutic Metabolic Effects of Tetrahydrocannabivarin (THCV)-Infused Mucoadhesive Strips.
Smith GL.Cannabis. 2025 Feb 1;8(1):109-120. doi: 10.26828/cannabis/2024/000206. eCollection 2025.PMID: 39968488 Free PMC article.
The study evaluated the efficacy of two different doses of THCV and C*D (8 mg THCV/10 mg C*D in the lower dose and 16 mg THCV/20 mg C*D in the higher dose), taken once daily for 90 days via mucoadhesive oral strips, for weight loss and improvement of certain …
SKNY-1, a THCV A**log, Produces Weight Loss, Lipid Normalization and Attenuation of Reward-Associated Behaviors in an mc4r(G894C) Zebrafish Model of Obesity.
Angel I, Periyasamy K, Joseph B, Aminov E.Int J Mol Sci. 2026 May 12;27(10):4321. doi: 10.3390/ijms27104321.PMID: 42196303 Free PMC article.
The endocannabinoid system is a central regulator of appetite, lipid metabolism, and reward processing; however, first-generation cannabinoid receptor 1 (CB1) antagonists were limited by adverse neuropsychiatric effects. ...In vivo, mc4r(G894C) zebrafish mutants exhibited …
Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Pilot Study.
Jadoon KA, Ratcliffe SH, Barrett DA, Thomas EL, Stott C, Bell JD, O'Sullivan SE, Tan GD.Diabetes Care. 2016 Oct;39(10):1777-86. doi: 10.2337/dc16-0650. Epub 2016 Aug 29.PMID: 27573936 Clinical Trial.
RESEARCH DESIGN AND METHODS: In this randomized, double-blind, placebo-controlled study, 62 subjects with noninsulin-treated type 2 diabetes were randomized to five treatment arms: C*D (100 mg twice daily), THCV (5 mg twice daily), 1:1 ratio of C*D and THCV (5 mg/5 …
It Is Our Turn to Get Cannabis High: Put Cannabinoids in Food and Health Baskets.
Salami SA, Martinelli F, Giovino A, Bachari A, Arad N, Mantri N.Molecules. 2020 Sep 4;25(18):4036. doi: 10.3390/molecules25184036.PMID: 32899626 Free PMC article. Review.
Nevertheless, despite the low concentration, cannabinol (CBN), cannabigerol (CBG), cannabichromene (CBC), tetrahydrocannabivarin (THCV), cannabidivarin (C*DV), cannabinodiol (CBND), and cannabinidiol (C*DL) may have potentially some medical effects. ...Despite all concerns …
The CB1 receptor as a convergence hub linking stress, sleep and appetite regulation: An integrative neurobiological model.
da Rosa RA, de Pontes LR, Pablos AB, Kreffta GS.Neurosci Biobehav Rev. 2026 Oct;189:106863. doi: 10.1016/j.neubiorev.2026.106863. Epub 2026 Jul 10.PMID: 42431566 Free article. Review.
In vitro and in vivo pharmacological activity of minor cannabinoids isolated from Cannabis sativa.
Zagzoog A, Mohamed KA, Kim HJJ, Kim ED, Frank CS, Black T, Jadhav PD, Holbrook LA, Laprairie RB.Sci Rep. 2020 Nov 23;10(1):20405. doi: 10.1038/s41598-020-77175-y.PMID: 33230154 Free PMC article.
Partial agonism of CB1R by (9)-THC is known to bring about the 'high' associated with Cannabis use, as well as the pain-, appetite-, and anxiety-modulating effects that are potentially therapeutic. CB2R activation by certain cannabinoids has been associated with anti-infl …
Delta9-tetrahydrocannabivarin as a marker for the ingestion of ma*****na versus Marinol: results of a clinical study.
ElSohly MA, deWit H, Wachtel SR, Feng S, Murphy TP.J A**l Toxicol. 2001 Oct;25(7):565-71. doi: 10.1093/jat/25.7.565.PMID: 11599601 Clinical Trial.
We have previously proposed the use of delta9-tetrahydrocannabivarin (THCV, the C3 homologue of THC) as a marker for the ingestion of ma*****na (or a related product) because THCV is a natural component of most cannabis products along with THC and does not exist in …
The Impact of Major and Minor Phytocannabinoids on the Maintenance and Function of INS-1 β-Cells Under High-Glucose and High-Lipid Conditions.
Gojani EG, Wang B, Li DP, Kovalchuk O, Kovalchuk I.Molecules. 2025 Apr 30;30(9):1991. doi: 10.3390/molecules30091991.PMID: 40363798 Free PMC article.
This system has been implicated in metabolic disorders like obesity and diabetes, as it helps to regulate appetite, food intake, and fat production. Phytocannabinoids from Cannabis sativa have the potential to influence the endocannabinoid system, offering a promising ther …
Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice.
Riedel G, Fadda P, McKillop-Smith S, Pertwee RG, Platt B, Robinson L.Br J Pharmacol. 2009 Apr;156(7):1154-66. doi: 10.1111/j.1476-5381.2008.00107.x.PMID: 19378378 Free PMC article.
Similarly, the effects of the phytocannabinoid Delta9-tetrahydrocannabivarin (Delta9-THCV), which behaves like a CB1 antagonist, were also determined in free-feeding animals. ...However, a Delta9-THCV-rich cannabis-extract failed to suppress food intake and weight g …
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