16/10/2026
“It [MCAS] is not the main driver of migraine, but it is a piece of the puzzle,” says Jennifer Robblee, MD, neurologist at the Lewis Headache Center in Phoenix, AZ.
Mast cells are part of our immune system and tend to be located in areas in close contact with the external environment, such as airways, the gastrointestinal (GI) tract, blood vessels, and nerves.
This release of histamine and other chemicals opens blood vessels, triggers swelling, creates mucus, and contracts smooth muscles in the airways and GI tract so the immune system can properly respond to the allergen.
https://bit.ly/4csk2hR